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Russian Chemical Bulletin

, Volume 67, Issue 4, pp 721–725 | Cite as

Antistress properties of sodium 1-N-acetylamino-1-carboxy-2-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate

  • I. V. Zhigacheva
  • M. M. Rasulov
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Abstract

The effect of a spatially-hindered phenol, namely sodium 1-N-acetylamino-1-carboxy-2-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate, on the functionality of mitochondria of rat liver was studied. Stress impact caused a 3 to 4-fold increase in the fluorescence intensity of the products of lipid peroxidation (LPO) in the membranes of these organelles. The preparation reduced the intensity of LPO to the control level, which was conductive to maintaining high functional activity of the mitochondria. Prevention of mitochondrial dysfunction was probably associated with an increase in the resistance of animals to stress factors.

Key words

anphen sodium sodium 1-N-acetylamino-1-carboxy-2-(3,5-di-tert-butyl-4- hydroxyphenyl)propionate adaptogen mitochondria lipid peroxidation mitochondrial dysfunction stress 

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Authors and Affiliations

  1. 1.M. Emanuel Institute of Biochemical PhysicsRussian Academy of SciencesMoscow, Russian FederationRussia
  2. 2.State Research Institute for Chemistry and Technology of Organoelement CompoundsMoscow, Russian FederationRussia

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