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Russian Chemical Bulletin

, Volume 67, Issue 4, pp 694–699 | Cite as

Synthesis of oxalic acid derivatives and their antitumor activity in experiments in vivo

  • B. S. Fedorov
  • S. A. Goncharova
  • T. A. Rajevskaya
  • A. B. Eremeev
  • A. N. Utenyshev
  • M. A. Fadeev
  • G. N. Bogdanov
  • N. P. Konovalova
  • S. M. Aldoshin
Full Article

Abstract

A series of amino acid derivatives of oxalic acid were obtained. In combination therapy with conventional cytostatics used in lower doses, the new compounds substantially increase the efficacy of the drugs in the treatment of experimental P388 murine leukemia and some its drug-resistant strains.

Key words

hydroxamic acids anticancer drugs adjuvant effect combination therapy murine leukemia drug-resistance in vivo 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • B. S. Fedorov
    • 1
  • S. A. Goncharova
    • 1
  • T. A. Rajevskaya
    • 1
  • A. B. Eremeev
    • 1
  • A. N. Utenyshev
    • 1
  • M. A. Fadeev
    • 1
  • G. N. Bogdanov
    • 1
  • N. P. Konovalova
    • 1
  • S. M. Aldoshin
    • 1
  1. 1.Institute of Problems of Chemical PhysicsRussian Academy of SciencesChernogolovka, Moscow Region, Russian FederationRussia

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