Advertisement

Russian Chemical Bulletin

, Volume 67, Issue 4, pp 655–662 | Cite as

Cerebral quantification of N-acetyl aspartate, aspartate, and glutamate levels in local structures of the human brain using J-editing of 1H magnetic resonance spectra in vivo

  • P. E. Menshchikov
  • N. A. Semenova
  • A. V. Manzhurtsev
  • T. A. Akhadov
  • S. D. Varfolomeev
Full Article
  • 17 Downloads

Abstract

A procedure was developed for the first time for simultaneous in vivo quantification of local aspartate and glutamate concentrations in the human brain using 1H magnetic resonance spectroscopy (1H MRS) and spectral J-editing. The MEGA-PRESS pulse sequence was modified to observe β-CH2 nonequivalent proton resonances of aspartate (δ 2.65 and 2.80) and glutamate (δ 2.04 and 2.12) overlapped by signals of other metabolites. The frequencies, frequency selective pulse durations, and optimal echo times were selected by simulation and experimentally (for phantoms and in the brain in vivo).

Key words

1H MRS MEGA-PRESS aspartate glutamate 1H MRS spectral J-editing 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    M. V. Ublinsky, N. Semenova, T. A. Akhadov, I. A. Melnikov, S. D. Varfolomeev, Russ. Chem. Bull., 2015, 64,451.CrossRefGoogle Scholar
  2. 2.
    A. V. Mangurtcev, N. A. Semenova, M. V. Ublinsky, Russ. Chem. Bull., 2016, 65, 1630.CrossRefGoogle Scholar
  3. 3.
    M. Gulyaev, N. Anisimov, N. Ustyuzhanina, Mendeleev Commun., 2016, 26,24.CrossRefGoogle Scholar
  4. 4.
    M. Miyake, Y. Kakimoto, M. Sorimachi, J. Neurochem., 1981, 36,804.CrossRefPubMedGoogle Scholar
  5. 5.
    J. Pan, K. Takahashi, Ann. Neurol., 2005, 57,92.CrossRefPubMedGoogle Scholar
  6. 6.
    J. Moffet, S. Tieman, D. Weinberger, J. Coyle, M. Namboodiry, in N-Acetyl Aspartate a Unique Neuronal Molecule in the Central Nervous System, Springer, N.-Y., 2006,375.Google Scholar
  7. 7.
    S. Gill, R. Small, D. Thomas, P. Patel, NMR Biomed., 1989, 2,196.CrossRefPubMedGoogle Scholar
  8. 8.
    J. Moffett, M. Namboodiri, J. Neale, Histochem. Cytochem., 1993, 41,559.CrossRefGoogle Scholar
  9. 9.
    M. Simmons, C. Frodonza, J. Coyle, Neurosci., 1991, 45,37.CrossRefGoogle Scholar
  10. 10.
    F. Federico, I. Simone, V. Lucivero, P. Giannini, G. Laddomada, D. Mezzapesa, C. Tortorella, Arch. Neurol., 1998, 55,489.CrossRefPubMedGoogle Scholar
  11. 11.
    C. Ford, R. Griffey, N. Matwiyoff, G. Rosenberg, Neurol., 1992, 42, 1408.CrossRefGoogle Scholar
  12. 12.
    G. Graham, P. Kalvach, A. Blamire, L. Brass, P. Fayad, J. Prichard, Stroke, 1995, 26,225.CrossRefPubMedGoogle Scholar
  13. 13.
    M. Lemesle, P. Walker, F. Guy, Acta Neurol. Scand., 2000, 102,1.Google Scholar
  14. 14.
    A. Pereira, D. Saunders, V. Doyle, J. Bland, F. Howe, J. Griffiths, M. Brown, Stroke, 1999, 30, 1577.CrossRefPubMedGoogle Scholar
  15. 15.
    A. Nikolaidis, P. Baniqued, M. Kranz, C. Scavuzzo, A. Bar bey, A. Kramer, R. Larsen, Cerebral Cortex, 2016, 45,1.Google Scholar
  16. 16.
    C. Dali, L. Hanson, N. Barton, J. Fogh, N. Nair, A. Lund, Neurol., 2010, 75, 1896.CrossRefGoogle Scholar
  17. 17.
    N. Semenova, S. Sidorin, T. Akhadov, Kletochnye Tekhnologii v Biologii i Meditsine [Cell Technologies in Biology and Medicine], 2011, 2, 99 (in Russian).Google Scholar
  18. 18.
    F. B. Goldstein, J. Biochem. Biophys. Acta, 1959, 33,583.CrossRefGoogle Scholar
  19. 19.
    C. Madhavarao, C. Chinopoulos, K. Chandrasekaran, M. Nam boodiri, J. Neurochem., 2003, 86,824.CrossRefPubMedGoogle Scholar
  20. 20.
    R. Margolis, S. Barkulis, A. Geiger, J. Neurochem., 1960, 5,379.CrossRefPubMedGoogle Scholar
  21. 21.
    M. Truckenmiller, M. Namboodiri, M. Browstein, J. Neale, J. Neurochem., 1985, 45, 1658.CrossRefPubMedGoogle Scholar
  22. 22.
    M. Robinson, R. Blakely, R. Couto, J. Coyle, J. Biol. Chem., 1987, 262, 14498.PubMedGoogle Scholar
  23. 23.
    B. Slusher, M. Robinson, G. Tsai, M. Simmons, S. Richards, J. Coyle, J. Biol. Chem., 1990, 265, 21297.PubMedGoogle Scholar
  24. 24.
    J. Moffet, P. Arun, P. Ariyannur, J. Garbern, D. Jacobowitz, A. Namboodiri, Glia, 2011, 59, 1414.CrossRefGoogle Scholar
  25. 25.
    M. Yudkoff, D. Nelson, Y. Daikhin, M. Erecinska, J. Biol. Chem., 1994, 269, 27414.PubMedGoogle Scholar
  26. 26.
    Y. Govindaraju, K. Young, A. Maudsley, NMR in Biomed., 2000, 13,129.CrossRefGoogle Scholar
  27. 27.
    W. Bogner, G. Hangel, M. Esmaeili, O. Andronesi, Analyt. Biochem., 2017, 529, 48CrossRefPubMedGoogle Scholar
  28. 28.
    L. Provencher, N. Puts, P. Barker, Magn. Reson. Med., 2012, 68,657.CrossRefGoogle Scholar
  29. 29.
    M. Thomas, Magn. Reson. Med., 2001, 46,58.CrossRefPubMedGoogle Scholar
  30. 30.
    L. Ryner, J. Sorenson, M. Thomas, Magn. Reson. Imaging, 1995, 13,853.CrossRefPubMedGoogle Scholar
  31. 31.
    M. Thomas, Magn. Reson. Mater. Phys. Biol. Med., 2008, 21,443.CrossRefGoogle Scholar
  32. 32.
    M. A. Thomas, NMR Biomed., 2009, 22,77.CrossRefPubMedGoogle Scholar
  33. 33.
    M. Mescher, H. Merkle, Biomed., 1998, 11,266.Google Scholar
  34. 34.
    R. Edden, P. Barker, Magn. Reson. Med., 2012, 68,657.CrossRefPubMedPubMedCentralGoogle Scholar
  35. 35.
    T. Melissa, H. Pierre-Gilles, Magn. Reson. Med., 2003, 50,19.CrossRefGoogle Scholar
  36. 36.
    R. Landim, R. Edden, L. Li, Magn. Reson. Imaging, 2016, 34,239.CrossRefPubMedGoogle Scholar
  37. 37.
    S. Smith, T. Levante, B. Meier, R. Ernst, J. Magn. Reson., 1994, 106,75.CrossRefGoogle Scholar
  38. 38.
    K. Chan, R. Edden, P. Barker, Magn. Reson. Mater. Phys. ISMRM (Honolulu, April 22–27, 2017).Google Scholar
  39. 39.
    F. Yamasaki, K. Kurisu, Y. Kajiwara, Neuro Oncol., 2011, 13,791.CrossRefPubMedPubMedCentralGoogle Scholar
  40. 40.
    L. Kaiser, K. Young, G. Matson, J. Magn. Reson., 2008, 17.Google Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • P. E. Menshchikov
    • 1
    • 2
  • N. A. Semenova
    • 1
    • 2
    • 3
  • A. V. Manzhurtsev
    • 2
    • 3
  • T. A. Akhadov
    • 1
  • S. D. Varfolomeev
    • 3
  1. 1.N. N. Semenov Institute of Chemical PhysicsRussian Academy of SciencesMoscow, Russian FederationRussia
  2. 2.Scientific Research Institute of Emergency Children’s Surgery and TraumatologyMoscow, Russian FederationRussia
  3. 3.N. M. Emanuel Institute of Biochemical PhysicsRussian Academy of SciencesMoscow, Russian FederationRussia

Personalised recommendations