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Russian Chemical Bulletin

, Volume 67, Issue 4, pp 655–662 | Cite as

Cerebral quantification of N-acetyl aspartate, aspartate, and glutamate levels in local structures of the human brain using J-editing of 1H magnetic resonance spectra in vivo

  • P. E. Menshchikov
  • N. A. Semenova
  • A. V. Manzhurtsev
  • T. A. Akhadov
  • S. D. Varfolomeev
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Abstract

A procedure was developed for the first time for simultaneous in vivo quantification of local aspartate and glutamate concentrations in the human brain using 1H magnetic resonance spectroscopy (1H MRS) and spectral J-editing. The MEGA-PRESS pulse sequence was modified to observe β-CH2 nonequivalent proton resonances of aspartate (δ 2.65 and 2.80) and glutamate (δ 2.04 and 2.12) overlapped by signals of other metabolites. The frequencies, frequency selective pulse durations, and optimal echo times were selected by simulation and experimentally (for phantoms and in the brain in vivo).

Key words

1H MRS MEGA-PRESS aspartate glutamate 1H MRS spectral J-editing 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • P. E. Menshchikov
    • 1
    • 2
  • N. A. Semenova
    • 1
    • 2
    • 3
  • A. V. Manzhurtsev
    • 2
    • 3
  • T. A. Akhadov
    • 1
  • S. D. Varfolomeev
    • 3
  1. 1.N. N. Semenov Institute of Chemical PhysicsRussian Academy of SciencesMoscow, Russian FederationRussia
  2. 2.Scientific Research Institute of Emergency Children’s Surgery and TraumatologyMoscow, Russian FederationRussia
  3. 3.N. M. Emanuel Institute of Biochemical PhysicsRussian Academy of SciencesMoscow, Russian FederationRussia

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