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Russian Chemical Bulletin

, Volume 66, Issue 1, pp 99–103 | Cite as

Modification of biologically active amides and amines with fluorine-containing heterocycles 12.* Endo- and exocyclic modifications of the drug riluzole with trifluoromethyl-containing heterocycles

  • V. B. SokolovEmail author
  • A. Yu. Aksinenko
  • A. V. Sokolov
  • A. Gabrelian
  • A. D. Efimova
  • V. V. Grigoriev
Full Articles

Abstract

New derivatives of the drug riluzole, 6-(trifluoromethoxy)benzothiazol-2-ylamine, modified at the endo- and exocyclic nitrogen atoms with trifluoromethyl-containing heterocycles were synthesized via transformations of methyltrifluoropyruvate and hexafluoroacetone N-6-(trifluoromethoxy)benzothiazol-2-ylimines by meams of cycloaddition and cyclocondensation reactions, respectively. The influence of the resulting compounds on neuronal NMDA receptors, as well as on the release and reuptake of the neurotransmitter glutamate was investigated.

Keywords

6-(trifluoromethoxy)benzothiazol-2-ylamine methyltrifluoropyruvate hexa-fluoroacetone cyanamines 1,3-binucleophiles cycloaddition cyclocondensation radioligand binding neuronal NMDA receptors glutamate 

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • V. B. Sokolov
    • 1
    Email author
  • A. Yu. Aksinenko
    • 1
  • A. V. Sokolov
    • 1
  • A. Gabrelian
    • 1
  • A. D. Efimova
    • 1
  • V. V. Grigoriev
    • 1
  1. 1.Institute of Physiologically Active CompoundsRussian Academy of SciencesChernogolovka, Moscow RegionRussian Federation

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