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Russian Chemical Bulletin

, Volume 65, Issue 2, pp 546–549 | Cite as

Antiproliferative activity of ruthenium and osmium clusters with phosphine ligands

  • A. A. NazarovEmail author
  • Yu. N. Nosova
  • O. V. Mikhalev
  • O. N. Kovaleva
  • P. J. Dyson
  • E. R. Milaeva
Full Articles

Abstract

New ruthenium and osmium carbonyl clusters with 1,3,5-triaza-7-phosphatricyclo-[3.3.1.13.7]decane and 3,7-diacetyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane ligands were synthesized using Me3NO as an initiator. The data on antiproliferative activity of new compounds against ovarian carcinoma cell cultures A2780 (cisplatin-sensitive) and A2780cisR (cisplatin-resistant) are reported. The dependence of cytotoxicity on the number of phosphine ligands was demonstrated.

Key words

ruthenium osmium clusters phosphine ligands antiproliferative activity 

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • A. A. Nazarov
    • 1
    Email author
  • Yu. N. Nosova
    • 1
  • O. V. Mikhalev
    • 1
  • O. N. Kovaleva
    • 2
  • P. J. Dyson
    • 3
  • E. R. Milaeva
    • 1
  1. 1.Department of ChemistryM. V. Lomonosov Moscow State UniversityMoscowRussian Federation
  2. 2.I. M. Sechenov First Moscow State Medical UniversityMoscowRussian Federation
  3. 3.Swiss Federal Institute of Technology in LausanneLausanneSwitzerland

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