Russian Chemical Bulletin

, Volume 65, Issue 2, pp 546–549 | Cite as

Antiproliferative activity of ruthenium and osmium clusters with phosphine ligands

  • A. A. NazarovEmail author
  • Yu. N. Nosova
  • O. V. Mikhalev
  • O. N. Kovaleva
  • P. J. Dyson
  • E. R. Milaeva
Full Articles


New ruthenium and osmium carbonyl clusters with 1,3,5-triaza-7-phosphatricyclo-[]decane and 3,7-diacetyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane ligands were synthesized using Me3NO as an initiator. The data on antiproliferative activity of new compounds against ovarian carcinoma cell cultures A2780 (cisplatin-sensitive) and A2780cisR (cisplatin-resistant) are reported. The dependence of cytotoxicity on the number of phosphine ligands was demonstrated.

Key words

ruthenium osmium clusters phosphine ligands antiproliferative activity 


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  1. 1.
    S. Dhar, S. J. Lippard, in Bioinorganic Medicinal Chemistry, Ed. E. Alessio, Wiley-VCH, Weinheim, 2011, p. 79.Google Scholar
  2. 2.
    B. Lippert, Cisplatin: Chemistry, Biochemistry of a Leading Anticancer Drug, Verlag Helvetica Chimica Acta, Zürich, 1999, p. 563.CrossRefGoogle Scholar
  3. 3.
    M. A. Jakupec, M. Galanski, V. B. Arion, C. G. Hartinger, B. K. Keppler, Dalton Trans., 2008, 183.Google Scholar
  4. 4.
    A. A. Nazarov, C. G. Hartinger, P. J. Dyson, J. Organomet. Chem., 2014, 751, 251.CrossRefGoogle Scholar
  5. 5.
    G. Sava, A. Bergamo, P. J. Dyson, Dalton Trans., 2011, 40, 9069.CrossRefGoogle Scholar
  6. 6.
    Z. Adhireksan, G. E. Davey, P. Campomanes, M. Groessl, C. M. Clavel, H. Yu, A. A. Nazarov, C. H. F. Yeo, W. H. Ang, P. Dröge, U. Rothlisberger, P. J. Dyson, C. A. Davey, Nat. Commun., 2014, 5, 3462.CrossRefGoogle Scholar
  7. 7.
    B. Wu, G. E. Davey, A. A. Nazarov, P. J. Dyson, C. A. Davey, Nucleic Acids Res., 2011, 39, 8200.CrossRefGoogle Scholar
  8. 8.
    F. Bacher, V. B. Arion, in Molecular Sciences, Chemical Engineering, Ed. J. Reedijk, Elsevier, Waltham, 2014.Google Scholar
  9. 9.
    C. G. Hartinger, M. A. Jakupec, S. Zorbas-Seifried, M. Groessl, A. Egger, W. Berger, H. Zorbas, P. J. Dyson, B. K. Keppler, Chem. Biodiversity, 2008, 5, 2140.CrossRefGoogle Scholar
  10. 10.
    C. Allardyce, P. Dyson, J. Cluster Sci., 2001, 12, 563.CrossRefGoogle Scholar
  11. 11.
    K. V. Kong, W. K. Leong, S. P. Ng, T. H. Nguyen, L. H. K. Lim, ChemMedChem, 2008, 3, 1269.CrossRefGoogle Scholar
  12. 12.
    A. A. Nazarov, M. Baquiè, P. Nowak-Sliwinska, O. Zava, J. R. van Beijnum, M. Groessl, D. M. Chisholm, Z. Ahmadi, J. S. McIndoe, A. W. Griffioen, H. van den Bergh, P. J. Dyson, Sci. Rep., 2013, 3, 1485.CrossRefGoogle Scholar
  13. 13.
    P. J. Dyson, S. J. McIndoe, Transition Metal Carbonyl Cluster Chemistry, CRC Press, Amsterdam, 2000.Google Scholar
  14. 14.
    R. Foresti, M. Bani-Hani, R. Motterlini, Intensive Care Medicine, 2008, 34, 649.CrossRefGoogle Scholar
  15. 15.
    U. Schatzschneider, Eur. J. Inorg. Chem., 2010, 2010, 1451.CrossRefGoogle Scholar
  16. 16.
    R. Alberto, R. Motterlini, Dalton Trans., 2007, 1651.Google Scholar
  17. 17.
    D. Darensbourg, F. Beckford, J. Reibenspies, J. Cluster Sci., 2000, 11.Google Scholar
  18. 18.
    D. Blazina, S. B. Duckett, P. J. Dyson, B. F. G. Johnson, J. A. B. Lohman, C. J. Sleigh, J. Am. Chem. Soc., 2001, 123, 9760.CrossRefGoogle Scholar
  19. 19.
    A. J. Deeming, S. Donovan-Mtunzi, S. E. Kabir, P. J. Manning, J. Chem. Soc., Dalton. Trans., 1985, 1037.Google Scholar
  20. 20.
    D. J. Minick, J. H. Frenz, M. A. Patrick, D. A. Brent, J. Med. Chem., 1988, 31, 1923.CrossRefGoogle Scholar
  21. 21.
    M. Hanif, A. A. Nazarov, A. Legin, M. Groessl, V. B. Arion, M. A. Jakupec, Y. O. Tsybin, P. J. Dyson, B. K. Keppler, C. G. Hartinger, Chem. Commun., 2012, 48, 1475.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • A. A. Nazarov
    • 1
    Email author
  • Yu. N. Nosova
    • 1
  • O. V. Mikhalev
    • 1
  • O. N. Kovaleva
    • 2
  • P. J. Dyson
    • 3
  • E. R. Milaeva
    • 1
  1. 1.Department of ChemistryM. V. Lomonosov Moscow State UniversityMoscowRussian Federation
  2. 2.I. M. Sechenov First Moscow State Medical UniversityMoscowRussian Federation
  3. 3.Swiss Federal Institute of Technology in LausanneLausanneSwitzerland

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