Russian Chemical Bulletin

, Volume 59, Issue 1, pp 136–143 | Cite as

Synthesis and antiviral activity of nucleoside analogs based on 1,2,4-triazolo[3,2-c][1,2,4]triazin-7-ones

  • V. L. Rusinov
  • O. N. Chupakhin
  • S. L. Deev
  • T. S. Shestakova
  • E. N. Ulomskii
  • L. I. Rusinova
  • O. I. Kiselev
  • E. G. Deeva
Full Articles

Abstract

Nucleoside analogs containing hydroxybutyl, hydroxyethoxymethyl, allyloxymethyl, and propargyloxymethyl fragments were synthesized based on 1,2,4-triazolo[3,2-c][1,2,4]triazin-7-ones isosteric to purine bases. Some of the compounds obtained inhibit in vitro reproduction of influenza and respiratory syncytial virus infection.

Key words nucleoside analogs antiviral drugs 1,2,4-triazolo[3,2-c][1,2,4]triazin-7-one derivatives 

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Copyright information

© Springer Science+Business Media, Inc.  2010

Authors and Affiliations

  • V. L. Rusinov
    • 1
    • 2
  • O. N. Chupakhin
    • 1
    • 2
  • S. L. Deev
    • 1
  • T. S. Shestakova
    • 1
  • E. N. Ulomskii
    • 1
  • L. I. Rusinova
    • 1
  • O. I. Kiselev
    • 3
  • E. G. Deeva
    • 3
  1. 1.B. N. Eltsyn Ural State Technical University — UPIEkaterinburgRussian Federation
  2. 2.I. Ya. Postovsky Institute of Organic SynthesisUral Branch of the Russian Academy of SciencesEkaterinburgRussian Federation
  3. 3.Influenza Research InstituteRussian Academy of Medical SciencesSt.-PetersburgRussian Federation

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