Russian Chemical Bulletin

, Volume 55, Issue 11, pp 1869–1882

1,3-dipolar cycloaddition of nitrones to free and coordinated nitriles: Routes to control the synthesis of 2,3-dihydro-1,2,4-oxadiazoles

  • N. A. Bokach
  • V. Yu. Kukushkin

DOI: 10.1007/s11172-006-0528-0

Cite this article as:
Bokach, N.A. & Kukushkin, V.Y. Russ Chem Bull (2006) 55: 1869. doi:10.1007/s11172-006-0528-0


Data on 1,3-dipolar cycloaddition of nitrones to free and coordinated nitriles producing 2,3-dihydro-1,2,4-oxadiazoles (or Δ4-1,2,4-oxadiazolines) are summarized. The latter compounds belong to the virtually unknown class of heterocyclic systems. The main factors responsible for the cycloaddition reactions are discussed. Particular attention is given to the role of metal centers in controlling the synthesis of 2,3-dihydro-1,2,4-oxadiazoles.

Key words

1,3-dipolar cycloaddition nitriles nitrile complexes nitrones reactivity 

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • N. A. Bokach
    • 1
  • V. Yu. Kukushkin
    • 1
  1. 1.Department of ChemistrySt. Petersburg State UniversityStary PetergofRussian Federation

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