A measurement of decreasing impatience for health and money
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Abstract
This paper measures deviations from constant discounting and compares these deviations for health and money. Our measurements make no assumptions about utility and do not require separability of preferences over time. In an experiment, most subjects were decreasingly impatient, but a substantial minority was increasingly impatient. The deviations from constant discounting were more pronounced for health than for money suggesting that time preferences are domainspecific. Hyperbolic discounting (Loewenstein and Prelec, Quarterly Journal of Economics, 107, 573–597, 1992) and proportional discounting (Mazur, Quantitative Analyses of Behavior, 5, 55–73, 1987) best described time preferences. Quasihyperbolic discounting, the most popular model to accommodate deviations from constant discounting, was rejected for both health and money.
Keywords
Time preference Decreasing impatience Hyperbolic discounting HealthJEL Classifications
D91 I101 Introduction
Private and policy decisions often involve outcomes that occur at different points in time. Some examples include choosing a pension plan and funding a screening program that reduces future illness. To account for their differences in timing, outcomes are usually discounted at a constant rate.
Constant discounting is tractable and has normative appeal, but it is inconsistent with observed behavior. Empirical evidence shows that discount rates typically decrease over time (Frederick et al. 2002; Attema 2012). Most evidence for decreasing impatience comes from studies using money outcomes, but it has also been observed for other domains such as health and environmental outcomes (Bleichrodt and Johannesson 2001; Van der Pol and Cairns 2011; van der Pol and Cairns 2002; Khwaja et al. 2007; Hardisty and Weber 2009; Cairns and Van der Pol 1997).
The violations of constant discounting have implications for policy. From Strotz (1955), we know that a decision maker who deviates from constant discounting may be prone to behave inconsistently over time and may have selfcontrol problems, which lead to selfharming behaviors such as saving too little, addiction (Gruber and Köszegi 2001) and obesity (Scharff 2009; Ikeda et al. 2010). These selfcontrol problems, in turn, may increase the welfare benefits from policy. For example, the net benefit of an increased tax on smoking may be much larger when the smoker does not discount at a constant rate, because the tax can serve as a commitment device that reduces the smoker’s selfcontrol problems and which he, therefore, values (Gruber and Kőszegi 2004).
To assess the severity of departure from constant impatience, and, consequently, the vulnerability to selfcontrol problems and the potential benefits from policy, the degree of decreasing impatience must be quantified. This is the aim of our paper.
Prelec (2004) showed that decreasing impatience cannot be quantified by looking at the speed of decline of discount rates. Hence, the abovementioned studies that found support for decreasing impatience and compared discount rates cannot be used to quantify decreasing impatience. Prelec argued that decreasing impatience should be measured by the PrattArrow convexity of the logarithm of the discount function. Unfortunately, this measure is hard to observe empirically. Instead, we will use the method of Attema et al. (2010), which is informationally equivalent to Prelec’s measure and can easily be applied empirically to measure the degree of decreasing impatience. Attema et al.’s measure makes no assumptions about utility or intertemporal separability. Existing studies on time preference generally imposed parametric assumptions on utility (most studies assumed linear utility) and assumed intertemporal separability. These assumptions cause distortions in the measurement of time preferences (Attema et al. 2012; Broome 1991; Loewenstein and Prelec 1993). Finally, Attema et al.’s method allows analyses at the individual level and, as we will show, individual time preferences are heterogeneous.
In an experiment, we compared deviations from constant discounting for money and health, two domains where economic analyses are widely used and discounting is routinely applied. Knowing whether time preferences are the same for health and money is important for both research and policy. Researchers often assume the same (constant) discounting of money and health and government offices try to set a single official discount rate to evaluate all public investments. If markets worked perfectly then this would be the appropriate discounting policy (Moore and Viscusi 1990). However, health is less transferable over time than money and there is no market for health to observe. In the presence of such market imperfections, it is unclear whether health and money should be discounted similarly. As noted by Moore and Viscusi (1990, p.52), this question must be resolved empirically, which is what the current paper seeks to do.
Several papers have compared discount rates for health and money. As mentioned above, the results from these studies cannot answer whether the degree of decreasing impatience differs between health and money, but they do shed light on whether people discount health and money similarly. The results are mixed (Attema 2012). While Moore and Viscusi (1990) and Cropper et al. (1994) found the same discounting for health and money, Cairns (1992) found more discounting for money and Cairns (1994) and Hardisty and Weber (2009) found more discounting for health gains and less for health losses. Moreover, the correlation between discounting for health and discounting for money is typically low (Chapman and Elstein 1995; Chapman 1996).
The empirical deficiencies of constant discounting have led to a variety of new discount models. The most widelyused of these is quasihyperbolic discounting (Phelps and Pollak 1968; Laibson 1997), which has become part of mainstream economics (Gruber and Köszegi 2001; Diamond and Köszegi 2003; DellaVigna 2009). Empirical evidence on the relative performance of these new discount models is thin on the ground, especially for health. This is unfortunate given the increasing use of these models in health (Gruber and Köszegi 2001; Gruber and Kőszegi 2004; Newhouse 2006; Fang and Wang 2015). A final contribution of this paper is to present evidence about the descriptive validity of discount models.
Our results indicate that most subjects deviated from constant discounting and were decreasingly impatient for both money and health. Between 25% (for health) and 35% (for money) of our subjects behaved according to increasing impatience, a finding that most discount models cannot explain. Subjects deviated more from constant discounting for health than for money. This domaindependence of discounting suggests that evidence on time preferences for money has only limited validity for health. Of the discounting models that we explored, hyperbolic discounting (Loewenstein and Prelec 1992) and proportional discounting (Mazur 1987) described time preferences for health and money best. Quasihyperbolic discounting and constant discounting could be rejected for both health and money.
2 Background
In Eq. (1), φ is a decreasing and positive discount function and U is a realvalued utility function. Because φ is decreasing, the decision maker is impatient and prefers to receive good outcomes sooner rather than later. We scale φ such that φ(0) = 1. Utility is defined relative to a neutral outcome which has the value 0. For money the neutral outcome was receiving nothing, for health we selected a specific health state (chronic back pain) that we assigned the value 0.
Constant impatience says that preferences between timed outcomes do not change if we delay them by a common constant: for all σ > 0 , (x, s) ~ (y, t) with 0 ≺ x ≺ y and s < t implies (x, s + σ) ~ (y, t + σ). Koopmans (1960) showed that constant impatience implies constant discounting: φ(t) = δ ^{ t } for 0 < δ < 1. Decreasing impatience holds if adding a common delay makes people more willing to wait for the better outcome: for all σ > 0 , (x, s) ~ (y, t) with 0 ≺ x ≺ y and s < t implies (x, s + σ) ≼ (y, t + σ). Empirical studies have often found decreasing impatience, for both money (Frederick et al. 2002) and health (Attema 2012). Increasing impatience is the opposite of decreasing impatience and means that adding a common delay makes people less willing to wait for a larger outcome: for all σ > 0 , (x, s) ~ (y, t) with 0 ≺ x ≺ y and s < t implies (x, s + σ) ≽ (y, t + σ). Several studies have found increasing impatience for money (e.g. Attema et al. 2010; Sayman and Öncüler 2009; Scholten and Read 2006; Loewenstein 1987; Takeuchi 2011). For health, only indirect evidence of increasing impatience exists (Attema et al. 2012).
Let ≽_{ a } and ≽_{ b } be the preference relations over timed outcomes of decision makers a and b. We say that ≽_{ b } is more decreasingly impatient than ≽_{ a } if for all 0 ≤ s < t, for all ε, and for all outcomes 0 ≺_{ a } x ≺_{ a } y , 0≺_{ b } x′ ≺_{ b } y′, if (x, s) ∼_{ a } (y, t), (x, s + σ) ∼_{ a } (y, t + σ + ε) and (x′, s) ∼_{ b } (y′, t) then (x′, s + σ) ≺_{ b } (y′, t + σ + ε). Intuitively, if both a and b are willing to wait from period s to period t to receive a larger outcome (y instead of x for decision maker a and y′ instead of x′ for decision maker b), they are equally impatient for these outcomes and periods. Now, if a is also willing to wait from period s + σ to period t + σ + ε to receive y instead of x then b will prefer the larger later outcome (y′, t + σ + ε), because his impatience decreases faster than that of a and, thus, he becomes more futureoriented than a.
Analogously, ≽_{ b } is more increasingly impatient than ≽_{ a } if for all 0 ≤ s < t, for all σ > 0, for all ε, and for all outcomes 0 ≺_{ a } x ≺_{ a } y , 0 ≺_{ b } x′ ≺_{ b } y′, if (x, s) ∼_{ a } (y, t), (x, s + σ) ∼_{ a } (y, t + σ + ε) and (x′, s)∼_{ b } (y′, t) then (x′, s + σ)≻_{ b }(y′, t + σ + ε).
The parameter h measures decreasing impatience. If h = 0 then hyperbolic discounting is equivalent to constant discounting and the larger h is, the more the decision maker deviates from constant discounting. Two special cases of hyperbolic discounting are proportional discounting (Mazur 1987), which results from Eq. (3) when h = r and power discounting (Harvey 1986), which results when h = 1.
For money, Abdellaoui et al. (2010, 2013) concluded that hyperbolic discounting performed better than constant, quasihyperbolic, proportional, and power discounting, even after correction for the differences in degrees of freedom. For health, van der Pol and Cairns (2002) found some evidence that hyperbolic discounting and power discounting fitted better than constant discounting and proportional discounting. Bleichrodt and Johannesson (2001) and Van der Pol and Cairns (2011) found that hyperbolic discounting fitted better than constant discounting and quasihyperbolic discounting for health.
3 Time tradeoff sequences
Because deviations from constant impatience are closely related to economic and health misbehaviors, it is of interest to measure these deviations.^{1} Prelec (2004) argued that deviations from constant impatience should be measured by the PrattArrow convexity of the logarithm of the discount function: −ln(φ)′′/ ln (φ)′. This measure is hard to observe empirically. First, we must measure the discount function, which is complex because discounting and utility interact, then we must take the logarithm, and, finally, we must compute first and second derivatives.
Eq. (6) shows that a time tradeoff sequence is equally spaced in terms of ln(φ). This property does not depend on utility. Utility drops from Eqs. (5) and (6) and we do not have to make any assumptions about it.
From Eq. (7), τ(t _{0}) = 1, τ(t _{ k }) = 0, and τ(t _{ j }) = 1 − j/k. Because τ(t _{ j }) = 1 − j/k, the elements of the time tradeoff sequence are also equally spaced in terms of τ. Under constant discounting τ is linear, under decreasing impatience it is convex, and under increasing impatience it is concave. Attema et al. (2010) showed that τ has the same degree of convexity as ln(φ): \( \frac{\tau^{\prime \prime }}{\tau^{\prime }} \) = \( \frac{{ \ln \left(\upvarphi \right)}^{\prime \prime }}{ \ln {\left(\upvarphi \right)}^{\prime }} \). In other words, τ can be used instead of ln(φ) to measure decreasing impatience and decision maker a is more decreasingly impatient than decision maker b if a’s time curve is more convex than b’s time curve. The big advantage of using τ instead of ln(φ) is that τ is directly observable whereas ln(φ) is not.
 1.
Equal to zero under constant discounting,
 2.
Positive if t _{ i − 1} = 0 and zero if t _{ i − 1} > 0 under quasihyperbolic discounting,
 3.
Equal to h > 0 under hyperbolic discounting. Moreover, under hyperbolic discounting the denominator of Eq. (8) should be positive,
 4.
Equal to r under proportional discounting, and
 5.
Equal to 1 under power discounting.
4 Experiment
Our experiment elicited time tradeoff sequences for health and money. We recruited 75 students (36 female) from Erasmus University Rotterdam, mainly from economics and business. Every subject received a €12 participation fee. The experiment was computerrun in 14 small group sessions. Subjects were seated in cubicles and could not see each other’s screens or interact.
The experiment consisted of two parts, the elicitation of the time tradeoff sequences for health and for money. We randomized the order of these parts. Each part started with instructions and four comprehension questions (see the Online Appendix). After a subject had correctly answered all four comprehension questions, he answered two training questions. We told subjects that the training questions and the experimental questions had no right or wrong answers and that we were only interested in their preferences. Subjects were encouraged to ask questions at any time they wished should something be unclear.
Stimuli of the four sequences
Parts  Sequence  t_{0}  x  y 

Health  H1  Immediately  Treatment A  Treatment B 
H2  4 weeks  Treatment A  Treatment B  
Money  M1  Immediately  500 euro  550 euro 
M2  4 weeks  500 euro  550 euro 

You have moderate problems in walking about.

You have moderate problems performing your usual activities
(e.g., work, study, housework, family or leisure activities).

You have moderate pain or discomfort.
The descriptions of the treatments
Treatment A  Treatment B 

During one week  During one week 
• You have moderate problems in walking about.  • You have slight problems in walking about. 
• You have moderate problems with performing your usual activities (e.g. work, study, housework, family or leisure activities).  • You have no problem with performing your usual activities (e.g. work, study, housework, family or leisure activities) 
• You have no pain or discomfort.  • You have no pain or discomfort. 
Our instructions told subjects to adopt chronic back pain as their neutral level of health. Because most subjects were healthy, chronic back pain could have been perceived as a loss and not as neutral. However, empirical evidence suggests that the reference point or neutral level of health can be manipulated and even healthy subjects usually adopt a health state which is worse than their current health if instructed to do so (Bleichrodt and Pinto 2002; Attema et al. 2013; van Osch et al. 2006).
Each sequence consisted of four elements (k = 4). All indifferences were elicited using a series of choices. This procedure is common in experimental economics, because it leads to fewer inconsistencies than directly asking subjects for their indifference values (Bostic et al. 1990). We will describe the choicebased elicitation procedure for health. It was similar for money with €500 instead of Treatment A and with €550 instead of Treatment B.
The upper bound for the delay in Option B was 500 weeks. If a subject still preferred B for a delay of 500 weeks, we also treated his response to this question as missing. Six subjects did this at least once. These subjects were the most patient. To test whether the exclusion of the most patient subjects biased the results, we repeated the individual analyses by also excluding the six most impatient subjects. This robustness check led to the same conclusions in all but one case and we will only report the single case where the results differed.
5 Results
We removed a subject’s missing choices, but kept the other, completed, choices in the aggregate analyses. In the individual analyses, we needed all choices and the 12 subjects with missing data were removed.^{2} The individual analyses, therefore, used the responses of 63 subjects.
5.1 Consistency
For each subject we repeated two randomly selected elicitations, one for health and one for money to assess data quality. The consistency of the measurements was good. The original and the repeated measurements did not differ, neither for health (Wilcoxon test, p = 0.86) nor for money (Wilcoxon test, p = 0.58). The median absolute difference between the original and the repeated measurement was one week for both health and money.
5.2 Aggregate results
The data are inconsistent with quasihyperbolic discounting, which predicts that violations of constant discounting only occur when the present (time point 0) is involved and, hence, not in sequence H2. We could also test quasihyperbolic discounting by removing the first observation (the present) from sequence H1. Then all health outcomes occur in the future and quasihyperbolic discounting predicts constant impatience. This prediction could also be rejected (Page’s Ltest, p < 0.01).
Panels C and D in Fig. 3 show the time curves for the two money sequences M1 and M2. We could also reject constant impatience for money in favor of decreasing impatience (Page’s Ltest, both p < 0.01). The rejection of constant impatience in sequence M2 also violates quasihyperbolic discounting. Moreover, we could also reject the prediction of quasihyperbolic discounting that constant impatience should hold in sequence M1 when the first observation is removed (Page’s Ltest, p = 0.01).
Figure 3 suggests that the deviations from constant discounting were larger for health than for money. To test this conjecture, we fitted the time curves by an exponential function τ(t) = e ^{−αt }, where α reflects the convexity of the time curve and, thus, the degree of decreasing impatience\( \frac{\tau^{\prime \prime }}{\tau^{\prime }} \) = \( \frac{{ \ln \left(\upvarphi \right)}^{\prime \prime }}{ \ln {\left(\upvarphi \right)}^{\prime }} \). We used R (R Core Team 2013) and the nlme package (Pinheiro et al. 2014) to perform a nonlinear mixedeffects estimation of the exponential function with dummies to test for the fixed effects of outcome domain and the initial delay and subject as a random effect. Pvalues were obtained by likelihood ratio tests of the model with the dummy in question against the model without the dummy in question.
The exponential coefficients α were indeed larger for health than for money (LRtest, p < 0.01).We could not reject the null that the coefficients were the same for the two health sequences (LRtest, p = 0.47), but for money the coefficient of sequence M2 exceeded that of sequence M1 (LRtest, p < 0.01) signaling larger deviations from constant discounting in sequence M2. This finding, once again, contradicts quasihyperbolic discounting.
5.3 Individual results
To quantify decreasing impatience, we computed for each subject a decreasing impatience (DI) index. The DI index measures the difference between the area under the diagonal and the area under the normalized time curve.^{4} It is positive for a decreasingly impatient subject, zero for a constantly impatient subject, and negative for an increasingly impatient subject. However, a subject with a zero DI index is not necessarily constantly impatient. Subject 60 is a case in point. His time curve crosses the diagonal and his DI index was close to zero, but he did not behave according to constant impatience. To capture such preferences, we also computed a nonstationarity (NS) index, which measures the deviation from constant impatience.^{5} The NS index is related to the absolute value of the difference between the area under the diagonal and the area under the normalized time curve. The larger this area, the more a subject deviated from constant discounting. The analysis based on the NS index mostly gave the same results and we only present the results when they differed from those based on the DI index.
Classification of subjects for health based on the decreasing impatience indices
Sequence H2  

Decreasing impatience  Increasing impatience  Constant impatience  Subtotal  
Sequence H1  Decreasing impatience  27  5  4  36 
Increasing impatience  4  10  2  16  
Constant impatience  1  1  9  11  
Subtotal  32  16  15  Total: 63 
Classification of subjects for money based on the decreasing impatience indices
Sequence M2  

Decreasing impatience  Increasing impatience  Constant impatience  Subtotal  
Sequence M1  Decreasing impatience  22  6  2  30 
Increasing impatience  10  10  2  22  
Constant impatience  1  1  9  11  
Subtotal  33  17  13  Total: 63 
The DI indices indicated more decreasing impatience for health than for money. However, this difference was only significant in the comparison with sequence M1.^{6} The NS indices showed greater deviations from constant impatience for health than for money in all comparisons.^{7} The finding that the DI and NS indices of sequences H2 and M2 differed significantly from zero provided further evidence against quasihyperbolic discounting.
5.4 Hyperbolic factors
So far, the analysis has shown that our subjects violated constant and quasihyperbolic discounting for both health and money. To gain additional insight into the validity of the different discount models, we computed hyperbolic factors for each subject. The hyperbolic factors are undefined when their denominator is negative, which happens when a subject is extremely decreasingly impatient. Such behavior cannot be accommodated by any of the hyperbolic alternatives for constant discounting and requires more general discount models (Ebert and Prelec 2007; Bleichrodt et al. 2009). It was rare in our data. For each subject, we computed 24 hyperbolic factors, 6 per sequence. In all sequences, less than 10% of the hyperbolic factors had a negative denominator (5% in H1 and M1, 8% in H2 and M2).
We could not reject the null hypothesis of equal hyperbolic factors within each of the four sequences (Friedman test, all p > 0.09). However, this result was sensitive to the exclusion of the 6 most impatient subjects: without these subjects we could reject the null hypothesis of equal hyperbolic factors in sequence H2 (but not in the other three sequences). While most median hyperbolic factors equaled zero, all sequences contained at least one hyperbolic factor that was significantly different from 0 at the 1% significance level. This confirms, once again, that constant discounting and quasihyperbolic discounting did not hold. Finally, we could reject the prediction of power discounting that the hyperbolic factors equal 1 (Wilcoxon test, all p < 0.01). Consequently, the only models that were consistent with our data are Loewenstein and Prelec’s (1992) hyperbolic discounting and Mazur’s (1987) proportional discounting, except perhaps for sequence H2.
6 Discussion
The novelty of this paper is that we quantify deviations from constant discounting across two domains: health and money. This quantification gives new insights into subjects’ vulnerability to selfharming behavior and whether this vulnerability is domainspecific. Our tests make no assumptions about utility and they do not require intertemporal separability.
The main findings are as follows. First, our average subject deviated from constant discounting for both health and money and impatience decreased over time. However, time preferences were heterogeneous and a substantial minority of our subjects, between 25% and 35%, displayed increasing impatience. For money, our findings on increasing impatience confirm previous evidence (e.g. Attema et al. 2010; Sayman and Öncüler 2009; Loewenstein 1987; Takeuchi 2011; Chesson and Viscusi 2003; Rubinstein 2003). For health, only indirect evidence of increasing impatience existed.
The deviations from constant discounting were more pronounced for health than for money, which indicates that people might be more vulnerable to selfcontrol problems for health than for money. This finding also suggests that intertemporal preferences are contextdependent and that findings for money outcomes cannot be simply transferred to health. We may have found less decreasing impatience for money due to market forces. As money is tradable on financial markets and transferable across time, people’s discounting of money may have been disciplined by the prevailing interest rates for money (Cubitt and Read 2007). However, we also found that time preferences were less stable for money than for health, which seems to contradict the above conjecture.
Another possible reason for the difference between discounting for health and money may be that our subjects were more familiar with decisions about money than decisions about health. Yet, one would then, again, expect that time preferences would be more stable for money than for health, in contrast to our observation. Moreover, Chapman et al. (1999) found that familiarity with medical treatments did not increase the similarity between time preferences for money and health.
Possibly, time preferences were more stable for health than for money because subjects perceived their future health as more stable than their future income. For delays up to 10 years, which we considered in our experiment, health is usually rather stable and, moreover, we instructed subjects to assume that their baseline health would remain constant to chronic back pain. However, we did not tell subjects that their income would remain constant and, as they were students, substantial changes in their income were likely in the near future (after graduation). Consequently, subjects may have realized that their future evaluation of money would change. Our analysis assumed that the evaluation of money would not change over time and this may have affected the estimations. For a more detailed analysis of the impact of timedependence of utility on discounting behavior see Gerber and Rohde (2010, 2015).
Our final contribution is to obtain new evidence on the descriptive validity of discount models. Such evidence is still scarce, particularly for health. Hyperbolic discounting (Loewenstein and Prelec 1992) and proportional discounting best described intertemporal preferences, but it should be kept in mind that these two models cannot accommodate the behavior of the increasingly impatient subjects. To explain increasing impatience other discount functions are needed (Ebert and Prelec 2007; Bleichrodt et al. 2009). The widelyused quasihyperbolic discounting model was rejected for both money and health, casting doubt on the descriptive realism of studies that use this model to derive predictions about behavior.
Footnotes
 1.
 2.
Six subjects never switched between Options A and B and eight were extremely patient. Two of the extremely patient subjects never switched either. Therefore we excluded 12 subjects in total.
 3.
Decreasing impatience predicts that the WTW increases over the time tradeoff sequence, which was largely confirmed. In the first health sequence (H1), the first and the second WTW were lower than the third and the fourth WTW (Wilcoxon test, all p < 0.01), but the first WTW did not differ from the second WTW and the third WTW did not differ from the fourth WTW. In the second health sequence (H2) all predictions were confirmed (Wilcoxon test, p = 0.02 in the comparison between the first and the second WTW, all other p < 0.01) except that the third and the fourth WTW did not differ.
 4.
The normalized values of t _{ i } are: \( \overset{\sim }{t_i}=\frac{t_i{t}_0}{t_4{t}_0} \), i = 1 , … , 4. They lie between 0 and 1. The normalization was necessary to compare the indices between subjects and to perform statistical tests. The values of t _{ i } differed across subjects and, ceteris paribus, larger values of t _{ i } led to larger differences between the areas under the diagonal and under the time curve. The DI index is defined as: \( DI=\sum_{i=1}^4\left(\frac{i}{4}\overset{\sim }{t_i}\right) \).
 5.
The NS index is defined as: \( NS=\sum_{i=1}^4\left\frac{i}{4}\overset{\sim }{t_i}\right \).
 6.
Wilcoxon tests, p = 0.02 in the comparison between sequences H1 and M1, p = 0.18 in the comparison between H1 and M2, p = 0.03 in the comparison between sequences H2 and M1, and p = 0.19 in the comparison between sequences H2 and M2.
 7.
Wilcoxon tests, p = 0.02 in the comparison between sequences H1 and M1, p = 0.01 in the comparison between H1 and M2, p = 0.06 in the comparison between sequences H2 and M1, and p = 0.03 in the comparison between sequences H2 and M2.
Notes
Acknowledgments
Arthur Attema, Peter P. Wakker, the editor W. Kip Viscusi, and an anonymous reviewer gave helpful comments on earlier versions. We acknowledge financial support from the Erasmus Research Institute of Management (ERIM). Yu Gao’s research was support by a grant from the Netherlands Organisation for Scientific Research (NWO).
Supplementary material
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