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Synthesis, spectroscopic properties, crystal structures, antioxidant activities and enzyme inhibition determination of Co(II) and Fe(II) complexes of Schiff base

  • Kenan BuldurunEmail author
  • Nevin Turan
  • Ercan Bursal
  • Asim Mantarcı
  • Fikret Turkan
  • Parham Taslimi
  • İlhami Gülçin
Article
  • 37 Downloads

Abstract

Considering the importance of metal complexes in the development of medical science, two different Schiff base Fe(II) and Co(II) metal complex compounds were synthesized with Schiff base obtained through the condensation of 1-(4-aminophenyl)ethanone with 2-hydroxy-3-methoxybenzaldehyde. The reactions of the ligand with Co(II) and Fe(II) metal ions enabled six coordination compounds with octahedral geometries. The novel metal complexes were characterized by IR, elemental analyses, magnetic susceptibility, mass spectra, UV–Vis, thermogravimetry–differential thermal analysis (TGA–DTA) and X-ray diffraction analysis. The antioxidant properties of the new compounds were investigated using different in vitro assays. Moreover, enzyme inhibition of derivatives complexes against carbonic anhydrase I and II isoenzymes (CA I and II) and acetylcholinesterase (AChE) was evaluated. The best inhibitor complex for CA I and II isoenzymes was the Fe(II) complex with Ki values of 52.83 ± 11.52 and 63.34 ± 8.88, respectively.

Keywords

Schiff base Metal complexes Carbonic anhydrase Antioxidant activity Enzyme inhibition XRD analysis 

Notes

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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  • Kenan Buldurun
    • 1
    Email author
  • Nevin Turan
    • 1
  • Ercan Bursal
    • 2
  • Asim Mantarcı
    • 3
  • Fikret Turkan
    • 4
  • Parham Taslimi
    • 5
  • İlhami Gülçin
    • 6
  1. 1.Department of Chemistry, Faculty of Arts and SciencesMuş Alparslan UniversityMuşTurkey
  2. 2.Department of Nursing, School of HealthMuş Alparslan UniversityMuşTurkey
  3. 3.Department of Physics, Faculty of Arts and SciencesMuş Alparslan UniversityMuşTurkey
  4. 4.Health Services Vocational SchoolIgdır UniversityIgdırTurkey
  5. 5.Department of Biotechnology, Faculty of ScienceBartin UniversityBartinTurkey
  6. 6.Department of Chemistry, Faculty of ScienceAtaturk UniversityErzurumTurkey

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