Synthesis and crystal structures of phenylalanine ester-introduced palladium(II) and platinum(II) complexes and their cytotoxicities
Phenylalanine ester-introduced palladium(II) and platinum(II) complexes were synthesized. Taking advantage of the formation of Schiff bases by amino acids as an intermediate, the pyridylimine moiety coordinated to a metal center. Single crystals of each complex were obtained successfully, and their molecular structures were clarified in detail. The Pd(II) complex showed remarkable cytotoxicity compared to the Pt(II) complex.
KeywordsPhenylalanine Schiff base Crystal structure Palladium(II) complex Platinum(II) complex
This research was supported by a Grant-in-Aid for Scientific Research (C, 26410056), from the Ministry of Education, Culture, Sports, Science and Technology, Japan, and also supported by Kyoto-Advanced Nanotechnology Network.