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Efficient one-pot synthesis of 2,3-dihydroquinazoline-4(1H)-ones promoted by FeCl3/neutral Al2O3

  • Suo Juan Wu
  • Zi Qiang Zhao
  • Jing Shuo Gao
  • Bao Hua Chen
  • Guo Feng ChenEmail author
Article
  • 9 Downloads

Abstract

2,3-Dihydroquinazolin-4(1H)-one derivatives have been synthesized via one-pot reaction of isatoic anhydride, aromatic aldehyde, and ammonium acetate catalyzed by FeCl3/neutral Al2O3 in tert-butanol under reflux conditions. Inexpensive and easily available reagents, convenient work-up procedure, reusable catalyst, and moderate to good yield are the salient features of this protocol.

Keywords

2,3-Dihydroquinazolin-4(1H)-one FeCl3/neutral Al2O3 One-pot synthesis Isatoic anhydride Aldehydes 

Notes

Acknowledgements

The project was supported by the Education Department of Hebei Province Foundation for Youths (QN2015039) and the Foundation of Hebei University (no. 799207217002).

Supplementary material

11164_2018_3732_MOESM1_ESM.docx (1 mb)
Supplementary material 1 (DOC 1059 kb)

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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  • Suo Juan Wu
    • 1
  • Zi Qiang Zhao
    • 1
  • Jing Shuo Gao
    • 1
  • Bao Hua Chen
    • 2
  • Guo Feng Chen
    • 1
    Email author
  1. 1.Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental ScienceHebei UniversityBaodingPeople’s Republic of China
  2. 2.College of Pharmaceutical SciencesHebei UniversityBaodingPeople’s Republic of China

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