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Efficient one-pot synthesis of 2,3-dihydroquinazoline-4(1H)-ones promoted by FeCl3/neutral Al2O3

  • Suo Juan Wu
  • Zi Qiang Zhao
  • Jing Shuo Gao
  • Bao Hua Chen
  • Guo Feng ChenEmail author
Article
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Abstract

2,3-Dihydroquinazolin-4(1H)-one derivatives have been synthesized via one-pot reaction of isatoic anhydride, aromatic aldehyde, and ammonium acetate catalyzed by FeCl3/neutral Al2O3 in tert-butanol under reflux conditions. Inexpensive and easily available reagents, convenient work-up procedure, reusable catalyst, and moderate to good yield are the salient features of this protocol.

Keywords

2,3-Dihydroquinazolin-4(1H)-one FeCl3/neutral Al2O3 One-pot synthesis Isatoic anhydride Aldehydes 
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Notes

Acknowledgements

The project was supported by the Education Department of Hebei Province Foundation for Youths (QN2015039) and the Foundation of Hebei University (no. 799207217002).

Supplementary material

11164_2018_3732_MOESM1_ESM.docx (1 mb)
Supplementary material 1 (DOC 1059 kb)

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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  • Suo Juan Wu
    • 1
  • Zi Qiang Zhao
    • 1
  • Jing Shuo Gao
    • 1
  • Bao Hua Chen
    • 2
  • Guo Feng Chen
    • 1
    Email author
  1. 1.Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental ScienceHebei UniversityBaodingPeople’s Republic of China
  2. 2.College of Pharmaceutical SciencesHebei UniversityBaodingPeople’s Republic of China

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