Green synthesis of nano-titania (TiO2 NPs) utilizing aqueous Eucalyptus globulus leaf extract: applications in the synthesis of 4H-pyran derivatives

  • Siripireddy Balaji
  • Ramu Guda
  • Badal Kumar MandalEmail author
  • Mamatha KasulaEmail author
  • Eethamukkala Ubba
  • Fazlur-Rahman Nawaz Khan


We have presented the green synthesis and characterization of nano-titania (TiO2 NPs) by using Eucalyptus globulus leaf aqueous extract in a greener approach leading to their utilization as a catalyst in one-pot, three-component A3 coupling reactions. The composition of the as-prepared TiO2 NPs were confirmed by various analytical and spectroscopic techniques such as powder X-ray diffraction, scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis, dynamic light scattering analysis and specific surface area measured by Brunauer–Emmett–Teller analysis. TiO2 NPs exhibited a pure anatase phase structure with an average particle size of 12 nm.


Eucalyptus globulus leaf extract Green synthesis TiO2 NPs Catalysis Pyran derivatives 



The authors gratefully acknowledge to VIT University, Vellore, for providing a platform and basic characterization facility to do this work. We are slso sincerely thankful to UGC-NRC (Networking resource center) of the School of Chemistry, University of Hyderabad, for providing all necessary facilities and financial assistance to the program, and the Centre for Nanotechnology Research for providing the TEM facility for carrying out this work. We are slso sincerely thankful to ESAB INDIA-ESD Division, R&D Filler metals, Ambattur, Chennai, for the employment and financial support to successfully complete this research work.

Supplementary material

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Supplementary material 1 (DOCX 2624 kb)


  1. 1.
    M. Boominathan, N. Pugazhenthiran, M. Nagaraj, S. Muthusubramanian, S. Murugesan, N. Bhuvanesh, ACS Sustain. Chem. Eng. 1, 1405 (2013)CrossRefGoogle Scholar
  2. 2.
    V. Polshettiwar, R.S. Varma, Green Chem. 12, 743 (2010)CrossRefGoogle Scholar
  3. 3.
    C.N.R. Rao, A. Müller, A.K. Cheetham, Nanomaterials chemistry: recent developments and new directions (Wiley, Hoboken, 2007)CrossRefGoogle Scholar
  4. 4.
    S. Laurent, D. Forge, M. Port, A. Roch, C. Robic, L. Vander Elst, R.N. Muller, Chem. Rev. 108, 2064 (2008)CrossRefGoogle Scholar
  5. 5.
    C. Burda, X. Chen, R. Narayanan, M.A. El-Sayed, Chem. Rev. 105, 1025 (2005)CrossRefGoogle Scholar
  6. 6.
    Q. Chaudhry, M. Scotter, J. Blackburn, B. Ross, A. Boxall, L. Castle, R. Aitken, R. Watkins, Food Addit. Contam. 25, 241 (2008)CrossRefGoogle Scholar
  7. 7.
    D. Pan, J. Jiao, Z. Li, Y. Guo, C. Feng, Y. Liu, L. Wang, M. Wu, ACS Sustain. Chem. Eng. 3, 2405 (2015)CrossRefGoogle Scholar
  8. 8.
    H. Sutiono, A.M. Tripathi, H.-M. Chen, C.-H. Chen, W.-N. Su, L.-Y. Chen, H. Dai, B.-J. Hwang, ACS Sustain. Chem. Eng. 4, 5963 (2016)CrossRefGoogle Scholar
  9. 9.
    K. Assaker, C.D. Carteret, B.N.D. Lebeau, C. Marichal, L. Vidal, M.-J. Stébé, J.-L. Blin, ACS Sustain. Chem. Eng. 2, 120 (2013)CrossRefGoogle Scholar
  10. 10.
    R. Narayanan, M.A. El-Sayed, ACS J. Surf. Colloids 21, 2027 (2005)CrossRefGoogle Scholar
  11. 11.
    C. Copéret, M. Chabanas, R. Petroff Saint-Arroman, J.M. Basset, Angew. Chem. Int. Ed. 42, 156 (2003)CrossRefGoogle Scholar
  12. 12.
    J.M. Basset, J.P. Candy, C. Coperet, F. Lefebvre, E.A. Quadrelli, Nano Technol. Catal. 5, 447 (2004)CrossRefGoogle Scholar
  13. 13.
    V. Polshettiwar, C. Len, A. Fihri, Coord. Chem. Rev. 253, 2599 (2009)CrossRefGoogle Scholar
  14. 14.
    F. Shi, M.K. Tse, S. Zhou, M.-M. Pohl, J. Radnik, S. Hübner, K. Jähnisch, A. Brückner, M. Beller, J. Am. Chem. Soc. 131, 1775 (2009)CrossRefGoogle Scholar
  15. 15.
    V. Polshettiwar, B. Baruwati, R.S. Varma, Green Chem. 11, 127 (2009)CrossRefGoogle Scholar
  16. 16.
    J. Guo, S. Yuan, W. Jiang, H. Yue, Z. Cui, B. Liang, RSC Adv. 6, 4090 (2016)CrossRefGoogle Scholar
  17. 17.
    L.G. Devi, R. Kavitha, Rsc Adv. 4, 28265 (2014)CrossRefGoogle Scholar
  18. 18.
    E. Ubba, F.-R.N. Khan, E.D. Jeong, E.H. Chung, RSC Adv. 4, 57016 (2014)CrossRefGoogle Scholar
  19. 19.
    M.A. Henderson, Surf. Sci. 355, 151 (1996)CrossRefGoogle Scholar
  20. 20.
    M.A. Henderson, ACS J. Surf. Colloids 12, 5093 (1996)CrossRefGoogle Scholar
  21. 21.
    M.B. Hugenschmidt, L. Gamble, C.T. Campbell, Surf. Sci. 302, 329 (1994)CrossRefGoogle Scholar
  22. 22.
    A. Fahmi, C. Minot, A theoretical investigation of water adsorption on titanium dioxide surfaces. Surf. Sci. 304, 343 (1994)CrossRefGoogle Scholar
  23. 23.
    M.-H. Sun, S.-Z. Huang, L.-H. Chen, Y. Li, X.-Y. Yang, Z.-Y. Yuan, B.-L. Su, Chem. Soc. Rev. 45, 3479 (2016)CrossRefGoogle Scholar
  24. 24.
    R. Nalewajski, A. Köster, T. Bredow, K. Jug, J. Mol. Catal. 82, 407 (1993)CrossRefGoogle Scholar
  25. 25.
    G. Lu, A. Linsebigler, J.T. Yates Jr., J. Phys. Chem. 98, 11733 (1994)CrossRefGoogle Scholar
  26. 26.
    S. Suzuki, K.-I. Fukui, H. Onishi, T. Sasaki, Y. Iwasawa, Stud. Surf. Sci. Catal. 132, 753 (2001)CrossRefGoogle Scholar
  27. 27.
    U. Gesenhues, Chem. Eng. Technol. 24, 685 (2001)CrossRefGoogle Scholar
  28. 28.
    S. Verma, R. Nasir Baig, M.N. Nadagouda, R.S. Varma, ACS Sustain. Chem. Eng. 4, 4 (2016)Google Scholar
  29. 29.
    R. Narayanan, Green Chem. Lett. Rev. 5, 707 (2012)CrossRefGoogle Scholar
  30. 30.
    L.E. Oi, C. Min-Yee, H.V. Lee, H.C. Ong, S.B.A. Hamida, J.C. Juan, RSC Adv. 6, 108741 (2016)CrossRefGoogle Scholar
  31. 31.
    S.M. Ghouse, Y.S. Kumar, J.S. Jin, J.-P. Kim, J.S. Bae, E.H. Chung, E.K. Jang, F.-R.N. Khan, E.D. Jeong, RSC Adv. 4, 44408 (2014)CrossRefGoogle Scholar
  32. 32.
    A. Corma, A. Leyva-Pérez, M.J. Sabater, Chem. Rev. 111, 1657 (2011)CrossRefGoogle Scholar
  33. 33.
    A.S.K. Hashmi, Angew. Chem. Int. Ed. 49, 5232 (2010)CrossRefGoogle Scholar
  34. 34.
    U.M. Lindström, Chem. Rev. 102, 2751 (2002)CrossRefGoogle Scholar
  35. 35.
    J. Holzer, G. McCarthy, North Dakota State Univ., Fargo, North Dakota, USA, ICDD Grant-in-Aid (1990)Google Scholar
  36. 36.
    J. Ely, W. Haynes, B. Bain, J. Chem. Thermodyn. 21, 879 (1989)CrossRefGoogle Scholar
  37. 37.
    A.L. Patterson, Phys. Rev. 56, 978 (1939)CrossRefGoogle Scholar
  38. 38.
    R. Parra, M. Góes, M. Castro, E. Longo, P.R. Bueno, J.A. Varela, Chem. Mater. 20, 143 (2007)CrossRefGoogle Scholar
  39. 39.
    S. Yurdakal, B.S. Tek, O.U. Alagöz, V. Augugliaro, V. Loddo, G. Palmisano, L. Palmisano, ACS Sustain. Chem. Eng. 1, 456 (2013)CrossRefGoogle Scholar
  40. 40.
    S.I. Nikitenko, T. Chave, C. Cau, H.-P. Brau, V.R. Flaud, ACS Catal. 5, 4790 (2015)CrossRefGoogle Scholar
  41. 41.
    S. Salameh, J. Schneider, J. Laube, A. Alessandrini, P. Facci, J.W. Seo, L.C. Ciacchi, L. Mädler, ACS J. Surf. Colloids 28, 11457 (2012)CrossRefGoogle Scholar
  42. 42.
    S. Salameh et al., Powder Technol. 256, 345 (2014)CrossRefGoogle Scholar
  43. 43.
    E. Allen, J. Henshaw, P. Smith, A Review of Particle Agglomeration (AEA Technology plc, 2001)Google Scholar
  44. 44.
    L. Yang, C. Guo, L. Jia, K. Xie, Q. Shou, H. Liu, Ind. Eng. Chem. Res. 49, 8518 (2010)CrossRefGoogle Scholar
  45. 45.
    S. Joshi, I. Ghosh, S. Pokhrel, L. Mädler, W.M. Nau, ACS Nano 6, 5668 (2012)CrossRefGoogle Scholar
  46. 46.
    N. Mandzy, E. Grulke, T. Powder Technol. 160, 121 (2005)CrossRefGoogle Scholar
  47. 47.
    S. George, S. Pokhrel, Z. Ji, B.L. Henderson, T. Xia, L. Li, J.I. Zink, A.E. Nel, L. Mädler, J. Am. Chem. Soc. 133, 11270 (2011)CrossRefGoogle Scholar
  48. 48.
    J. Du, H. Sun, ACS Appl. Mater. Interfaces 6, 13535 (2014)CrossRefGoogle Scholar
  49. 49.
    S.I. Mogal, V.G. Gandhi, M. Mishra, S. Tripathi, T. Shripathi, P.A. Joshi, D.O. Shah, Ind. Eng. Chem. Res. 53, 5749 (2014)CrossRefGoogle Scholar
  50. 50.
    M. Dhananjeyan, E. Mielczarski, K. Thampi, P. Buffat, M. Bensimon, A. Kulik, J. Mielczarski, J. Kiwi, J. Phys. Chem. B 105, 12046 (2001)CrossRefGoogle Scholar
  51. 51.
    P. Bhattacharyya, K. Pradhan, S. Paul, A.R. Das, Tetrahedron Lett. 53, 4687 (2012)CrossRefGoogle Scholar
  52. 52.
    A. Saha, S. Payra, S. Banerjee, Green Chem. 17, 2859 (2015)CrossRefGoogle Scholar
  53. 53.
    K.A. El-Bayouki, W.M. Basyouni, T.K. Khatab, F.A. El-Basyoni, A.R. Hamed, E.A. Mostafa, J. Heterocycl. Chem. 51, 106 (2014)CrossRefGoogle Scholar

Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  • Siripireddy Balaji
    • 1
  • Ramu Guda
    • 2
  • Badal Kumar Mandal
    • 1
    Email author
  • Mamatha Kasula
    • 2
    Email author
  • Eethamukkala Ubba
    • 1
  • Fazlur-Rahman Nawaz Khan
    • 1
  1. 1.Department of Chemistry, School of Advanced SciencesVellore Institute of Technology (VIT)VelloreIndia
  2. 2.Department of ChemistryKakatiya UniversityWarangalIndia

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