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Research on Chemical Intermediates

, Volume 42, Issue 12, pp 8069–8081 | Cite as

Chitosan: a sustainable, reusable and biodegradable organocatalyst for green synthesis of 1,4-dihydropyridine derivatives under solvent-free condition

  • Sara Zhaleh
  • Nourallah HazeriEmail author
  • Mohammad Reza Faghihi
  • Malek Taher Maghsoodlou
Article

Abstract

Chitosan, a biodegradable green catalyst, was found to be an impressive system for one-pot four-component reaction of different aldehydes, dimedone, β‐ketoesters or acetoacetanilide, and ammonium acetate leading to 1,4-dihydropyridine derivatives via Hantzsch-type condensation under solvent-free condition. This methodology produces diverse superiorities such as operational simplicity, short reaction time, satisfied yield and recyclable catalyst. In this work, we attempted to develop several modifications for the classical Hantzsch conversion to report a novel eco-friendly method that is free from previously reported disadvantages.

Graphical Abstract

Keywords

Chitosan 1,4-Dihydropyridine Green synthesis Solvent-free condition Reusability 

Notes

Acknowledgment

The University of Sistan and Baluchestan is thanked for financial supporting of this work.

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Copyright information

© Springer Science+Business Media Dordrecht 2016

Authors and Affiliations

  • Sara Zhaleh
    • 1
  • Nourallah Hazeri
    • 1
    Email author
  • Mohammad Reza Faghihi
    • 1
  • Malek Taher Maghsoodlou
    • 1
  1. 1.Department of ChemistryUniversity of Sistan and BaluchestanZahedanIran

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