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Research on Chemical Intermediates

, Volume 42, Issue 5, pp 4893–4906 | Cite as

Di-n-butyl ammonium chlorosulfonate ionic liquids as an efficient and recyclable catalyst for the synthesis of 1,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carboxylates under solvent-free ultrasound irradiation

  • Mudumala Veeranarayana Reddy
  • Avuthu Vidya Sagar Reddy
  • Yeon Tae Jeong
Article

Abstract

In this study, we present a straightforward, efficient and convenient approach for the synthesis of medicinally important 1,4-dihydrobenzo[4,5] imidazo [1,2-a]pyrimidine-3-carboxylates via three-component reactions of aldehydes, 1H-benzo[d]imidazol-2-amine and active methylene compounds in the presence of di-n-butyl ammonium chlorosulfonate ionic liquids (DBA IL) under ultrasound irradiation. This process develops the synthetic potential of ultrasound irradiation with DBA IL combination and presents much compensation, such as outstanding product yields, reusable catalyst, less reaction periods, gainful cost, easy work-up/purification and environmentally benign reaction conditions.

Graphical Abstract

The attractive features of this methodology are simple procedure, green reaction, reusability and high efficiency of the catalyst, and easy workability.

Keywords

1,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carboxylates Di-n-butyl ammonium chlorosulfonate ionic liquids Ultrasound (US) irradiation Neat conditions 

Supplementary material

11164_2015_2328_MOESM1_ESM.docx (6.5 mb)
Supplementary material 1 (DOCX 6649 kb)

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Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  • Mudumala Veeranarayana Reddy
    • 1
  • Avuthu Vidya Sagar Reddy
    • 1
  • Yeon Tae Jeong
    • 1
  1. 1.Department of Image Science and EngineeringPukyong National UniversityBusanRepublic of Korea

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