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Research on Chemical Intermediates

, Volume 42, Issue 5, pp 4785–4795 | Cite as

Iron oxide-supported copper oxide nanoparticles catalyzed synthesis of propargyl amine derivatives via multicomponent approach

  • Gopinath Shirole
  • Vijay Kadnor
  • Sanjay Gaikwad
  • Nilesh Kshirsagar
  • Ganesh Mhaske
  • Sharad Shelke
Article

Abstract

The synthesis of propargyl amine derivatives was carried out via multicomponent reaction of substituted 1,3-diphenyl pyrazole aldehyde, phenyl acetylene, and morpholine in the presence of iron oxide-supported copper oxide nanocatalyst (Nanocat-Fe-CuO) with good yields. The Nanocat-Fe-CuO was easily separated from the products and reused to catalyze the reaction again with good yield. In the absence of catalyst reaction was not proceeding to any extent. The formation of compounds was confirmed on the basis of their IR, 1H-NMR, 13C-NMR, and mass spectral techniques.

Graphical Abstract

The synthesis of propargyl amine derivatives was carried out via multicomponent reaction of substituted 1,3-diphenyl pyrazole aldehyde, phenyl acetylene, and morpholine in presence of iron oxide-supported copper oxide nanocatalyst (Nanocat-Fe-CuO) with good yields. The Nanocat-Fe-CuO was easily separated from the products and reused to catalyze the reaction again with good yield. In the absence of a catalyst reaction did not proceed to any extent.

Keywords

1,3-diphenyl-pyrazole aldehyde Iron oxide-supported copper oxide nanocatalyst (Nanocat-Fe-CuO) Propargyl amine Morpholine Phenyl acetylene 

Abbreviations

MCRs

Multicomponent reactions

Nanocat-Fe-CuO

Iron oxide-supported copper oxide nanocatalyst

MNPs

Magnetic nanoparticles

RT

Room temperature

NR

No reaction

Notes

Acknowledgments

SS is very much thankful to BCUD, Savitribai Phule, Pune University, Pune, for financial support. We are also grateful to Principal Dr. K. P. Kakade, Dr. A. B. Nikumbh (HOD), SSGM College, Kopargaon and Principal Dr. B. K. Salalkar, Prof. A. S. Tambe (HOD), ASC College, Rahata, Ahmednagar (India) for providing infrastructural facilities and constant encouragement.

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Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  • Gopinath Shirole
    • 1
  • Vijay Kadnor
    • 2
  • Sanjay Gaikwad
    • 2
  • Nilesh Kshirsagar
    • 2
  • Ganesh Mhaske
    • 2
  • Sharad Shelke
    • 2
  1. 1.Department of ChemistryA.S.C. CollegeRahata, Dist-AhmednagarIndia
  2. 2.Department of ChemistryS.S.G.M. CollegeKopargaon, Dist-AhmednagarIndia

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