Research on Chemical Intermediates

, Volume 42, Issue 4, pp 2899–2908 | Cite as

Nano Fe3O4 as a magnetically recyclable, powerful, and stable catalyst for the multi-component synthesis of highly functionalized dihydro-2-oxopyrroles

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Abstract

A mild and efficient method for the one-pot synthesis of functionalized dihydro-2-oxopyrroles is described via four-component domino reaction of amines, dialkyl acetylenedicarboxylates, and formaldehyde in the presence of super magnetic nano iron oxide (nano Fe3O4) in EtOH at room temperature. The major advantages of the present method are mild and green reaction conditions, high yields, short reaction times, clean reaction, magnetically recyclable catalyst, atom economy (63–76 %), operational simplicity, and no need for column chromatography. It is found that the catalyst is recyclable and can be used up to six times without significant loss of its activity.

Graphical Abstract

Keywords

Nano Fe3O4 Heterocycle Dihydro-2-oxopyrrole Dialkyl acetylenedicarboxylate Green Magnetically recyclable Multi-component 
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Notes

Acknowledgments

Financial support from the Research Council of the University of Sistan and Baluchestan, the University of Kashan and the University of Shiraz is gratefully acknowledged.

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Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  1. 1.Department of Chemistry, Faculty of ScienceUniversity of Sistan and BaluchestanZahedanIslamic Republic of Iran
  2. 2.Department of Organic Chemistry, Faculty of ChemistryUniversity of KashanKashanIslamic Republic of Iran
  3. 3.Department of Chemistry, College of SciencesShiraz UniversityShirazIslamic Republic of Iran

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