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Research on Chemical Intermediates

, Volume 42, Issue 2, pp 771–811 | Cite as

Cyanoacetylation of amines: recent advances in preparation methods and their synthetic uses in the formation of biologically active compounds

  • Ahmed A. Fadda
  • Ramy RabieEmail author
Article

Abstract

A systematic and comprehensive survey of the preparation methods of N-cyanoacetamides is discussed in this review. Also, the chemical reactivity and reactions of this class to obtain biologically active novel heterocyclic moieties is described.

Keywords

N-cyanoacetamides Azirine Pyrrole Thiophene Pyrazole Imidazole Thiazole Thiadiazole Pyridine Pyrane Pyridazine Pyrimidine Diazpine Heterocycles 

Notes

Conflict of interest

The authors declare that they have no conflict of interest.

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© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  1. 1.Chemistry Department, Faculty of ScienceMansoura UniversityMansouraEgypt
  2. 2.Chemistry Lab.Mansoura Fevers HospitalMansouraEgypt

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