Research on Chemical Intermediates

, Volume 41, Issue 3, pp 1601–1606 | Cite as

A rapid and an efficient synthesis for 3,5-disubstituted 1,2,4-oxadiazoles under microwave irradiation

  • Moha Outirite
  • Michel Lagrenée
  • Belkheir Hammouti
  • Fouad Bentiss
Article

Abstract

The one-pot, three-component reaction of aromatic nitriles, hydroxylamine hydrochloride, and sodium carbonate in ethylene glycol provided 3,5-disubstituted 1,2,4-oxadiazoles. These 1,2,4-oxadiazole derivatives are quickly prepared under microwave irradiation (2 h) in high yields and excellent state of purity. The synthesized compounds were characterized by means of their 1H, 13C NMR, mass spectroscopy data and elemental analysis.

Keywords

1,2,4-Oxadiazole Nitrile Microwave NMR 

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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Moha Outirite
    • 1
  • Michel Lagrenée
    • 1
  • Belkheir Hammouti
    • 2
  • Fouad Bentiss
    • 3
  1. 1.Unité de Catalyse et de Chimie du Solide (UCCS), CNRS UMR 8181ENSCL Université Lille Nord de FranceVilleneuve d’Ascq CedexFrance
  2. 2.LCAE-URAC18, Faculté des SciencesUniversité Mohammed IerOujdaMorocco
  3. 3.Laboratoire de Catalyse et de Corrosion des Matériaux (LCCM), Faculté des SciencesUniversité Chouaib DoukkaliEl JadidaMorocco

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