Research on Chemical Intermediates

, Volume 40, Issue 2, pp 619–626 | Cite as

Degradation of biologically active substances by vapor-phase hydrogen peroxide

  • Jiří Švrček
  • Kamila Syslová
  • David Stíbal
  • Marek Kuzma
  • Petr Kačer
Article
  • 185 Downloads

Abstract

We have examined the potential of vapor-phase hydrogen peroxide (VPHP) for degradation of 21 structurally different pharmaceutical substances. Our results show that VPHP can be used to degrade pharmaceuticals, but it was not universally applicable to all the drugs tested. Structural analysis revealed a significant correlation of the molecular structure of a compound with its susceptibility to VPHP. Tertiary amino groups seem to be the initiation centers, although the overall susceptibility of a substance depends on other factors also. Several tested substances underwent significant structural changes, suggesting a possible decrease in their biological activity. As far as we are aware, this is one of the first reports of application of VPHP to the decontamination of hazardous chemicals.

Keywords

Vapor-phase hydrogen peroxide Pharmaceutical drugs Decontamination Degradation Bioactive compounds 

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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Jiří Švrček
    • 1
  • Kamila Syslová
    • 1
  • David Stíbal
    • 1
  • Marek Kuzma
    • 2
  • Petr Kačer
    • 1
  1. 1.Department of Organic TechnologyInstitute of Chemical Technology Prague (ICT Prague)Prague 6Czech Republic
  2. 2.Laboratory of Molecular Structure Characterization, Institute of Microbiology of ASCR, v.v.iPrague 4Czech Republic

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