Degradation of biologically active substances by vapor-phase hydrogen peroxide
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We have examined the potential of vapor-phase hydrogen peroxide (VPHP) for degradation of 21 structurally different pharmaceutical substances. Our results show that VPHP can be used to degrade pharmaceuticals, but it was not universally applicable to all the drugs tested. Structural analysis revealed a significant correlation of the molecular structure of a compound with its susceptibility to VPHP. Tertiary amino groups seem to be the initiation centers, although the overall susceptibility of a substance depends on other factors also. Several tested substances underwent significant structural changes, suggesting a possible decrease in their biological activity. As far as we are aware, this is one of the first reports of application of VPHP to the decontamination of hazardous chemicals.
KeywordsVapor-phase hydrogen peroxide Pharmaceutical drugs Decontamination Degradation Bioactive compounds
The project is supported by the grant of Ministry of Defense of the Czech Republic (OVVSCHT200901).
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