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Research on Chemical Intermediates

, Volume 40, Issue 1, pp 357–369 | Cite as

Silica-supported perchloric acid (HClO4–SiO2): a mild, reusable and highly efficient heterogeneous catalyst for multicomponent synthesis of 1,4-dihydropyridines via unsymmetrical Hantzsch reaction

  • Syed Sheik Mansoor
  • Krishnamoorthy Aswin
  • Kuppan Logaiya
  • Prasanna Nitiya Sudhan
  • Saleem Malik
Article

Abstract

Facile synthesis of some 1,4-dihydropyridine derivatives via Hantzsch reaction of 5,5-dimethyl-1,3-cyclohexanedione (dimedone), 1,3-diphenyl-2-propen-1-one derivatives and ammonium acetate under solvent-free condition in the presence of silica-supported perchloric acid (HClO4–SiO2) is described. The catalyst is easily prepared, stable, reusable and efficient under the reaction conditions.

Keywords

HClO4–SiO2 1,4-Dihydropyridine Hantzsch reaction Multicomponent reaction 

Notes

Acknowledgments

The authors gratefully acknowledge the University Grants Commission, Government of India, New Delhi for financial support (Major Research Project: F. No. 40-44/2011(SR)). The authors also acknowledge C. Abdul Hakeem College Management, Dr. W. Abdul Hameed, Principal and Dr. M. S. Dastageer, Head of the Research Department of Chemistry for the facilities and support.

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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Syed Sheik Mansoor
    • 1
  • Krishnamoorthy Aswin
    • 1
  • Kuppan Logaiya
    • 1
  • Prasanna Nitiya Sudhan
    • 1
  • Saleem Malik
    • 1
  1. 1.Bioactive Organic Molecule Synthetic Unit, Research Department of ChemistryC. Abdul Hakeem CollegeMelvisharamIndia

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