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Research on Chemical Intermediates

, Volume 39, Issue 9, pp 4091–4098 | Cite as

An efficient procedure for synthesis of 2, 3-dihydro-1H-indene-1-methanamines

  • Haiping Zhou
  • Huiting Su
  • Zongjie Gan
  • Dechuan Wang
  • Yungen Xu
Article

Abstract

An efficient synthetic method for 2, 3-dihydro-1H-indene-1-methanamine and its derivatives is described. Six compounds of 2, 3-dihydro-1H-indene-1-methanamines were synthesized from corresponding 4-nitro-3-phenylbutanoic acid in satisfactory yields (50.9–57.9 % in 4 steps), and three compounds (1c, 1e, 1f) were newly reported. This procedure has the advantages of mild conditions, less pollution, and simple manipulation.

Keywords

Synthesis Indene Methanamine 3-phenylbutanoic acid 

Notes

Acknowledgments

We are grateful to the National Natural Science Foundation of China (No. 81072520), the Natural Science Foundation of Jiangsu Province, China (No. BK2010435).

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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Haiping Zhou
    • 1
  • Huiting Su
    • 1
  • Zongjie Gan
    • 1
  • Dechuan Wang
    • 2
  • Yungen Xu
    • 1
  1. 1.Jiangsu Key Laboratory of Drug Design and OptimizationChina Pharmaceutical UniversityNanjingChina
  2. 2.Department of Organic ChemistryChina Pharmaceutical UniversityNanjingChina

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