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Research on Chemical Intermediates

, Volume 39, Issue 2, pp 585–595 | Cite as

Selective O-deallylation of dihydropyrazoles by molecular iodine in the presence of active N-allyl and formyl groups

  • Vivek T. HumneEmail author
  • Kamal Hasanzadeh
  • Pradeep D. Lokhande
Article

Abstract

Selective O-deallylation of dihydropyrazoles has been achieved by use of iodine (10 mol%) in PEG-400 as ecofriendly solvent. Iodine (10 mol%) in dimethyl sulfoxide at 100 °C also afforded O-deallylation with aromatization compatible with highly reactive N-allyl and formyl groups. The function of iodine in the synthesis of substituted pyrazoles under different conditions is described.

Keywords

Iodine Dihydropyrazole Deallylation PEG-400 

Notes

Acknowledgment

VTH thanks CSIR, New Delhi, India, for the award of a Senior Research Fellowship.

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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Vivek T. Humne
    • 1
    Email author
  • Kamal Hasanzadeh
    • 1
  • Pradeep D. Lokhande
    • 1
  1. 1.Center for Advance Studies, Department of ChemistryUniversity of PunePuneIndia

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