Research on Chemical Intermediates

, Volume 37, Issue 6, pp 627–633 | Cite as

Substituted-nicotinyl thiourea derivatives bearing pyrimidine moiety: synthesis and biological evaluation

  • Shaoyong KeEmail author
  • Xiufang CaoEmail author


A series of substituted-nicotinyl thiourea derivatives containing pyrimidine ring were synthesized in good to excellent yield using PEG-400 as solid–liquid phase transfer catalyst under ultrasonic irradiation. The structures of all newly synthesized compounds were elucidated and confirmed by IR, 1H NMR and elemental analysis. The preliminary biological tests show that some of the target compounds present good inhibitory activities against the root and stalk of dicotyledon plants and are safe for monocotyledon plants.


Nicotinyl thiourea PTC Synthesis Bioactivity 



This work was financially supported by the Projects in the National Science and Technology Pillar Program during the Eleventh Five-Year Plan Period (2008BADA5B03) and Special Fund for Agro-Scientific Research in the Public Interest (200903052).


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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  1. 1.Hubei Biopesticide Engineering Research CenterHubei Academy of Agricultural SciencesWuhanPeople’s Republic of China
  2. 2.College of ScienceHuazhong Agricultural UniversityWuhanPeople’s Republic of China

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