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Correction to: Statins, metformin, proprotein-convertase-subtilisin-kexin type-9 (PCSK9) inhibitors and sex hormones: Immunomodulatory properties?

  • Christian A. KochEmail author
  • Siegfried Krabbe
  • Bernd HehmkeEmail author
Correction
  • 329 Downloads

Correction to: Reviews in Endocrine and Metabolic Disorders (2018) 19:363–395

  https://doi.org/10.1007/s11154-018-9478-8

The authors would like to note that several errors had occurred, especially in Table 2, Tables 5, 6 and 7, Figure 13, and in the legend of Figure 23.
Table 7

Effect of the lipid-lowering drug simvastatin on the frequency of proinflammatory Interferon-gamma+ and regulatory IL-10+ thyroid-autoreactive CD4+ T helper cells in patients with autoimmune thyroiditis in comparison to untreated patients and healthy donors

 

Cytokine phenotype of thyroid-autoreactive T cells§ (frequency)

Group

Tr1

Tr0

Th1

Tr1+Tr0

Tr0+Th1

Tr1+Th1

Tr1+Tr0+Th1

Thyreoiditis, without simvastatin treatment (n=31)

4.83 %

7.25 %

6.34 %

10.57 %

2.11 %

0.30 %

2.11 %

Thyreoiditis, treated with 40 mg/d simvastatin (n=7)

10.39 %

10.39 %

1.30 %

19.48 %#

0.00 %

0.00 %

0.00%

Healthy donors (n=29)

8.57 %

10.15 %

0.00 %

8.89%

2.54 %

0.32 %

0.63 %

Data are given as percentage of T cell cultures with the corresponding cytokine phenotype in relation to the total number of T cell test cultures

§Tr1: T regulatory type 1, IL-10+; Tr0: T regulatory type 0, IFN-γ+IL-10+; Th1: T helper type 1, IFN-γ+

p < 0.0001 vs. healthy donors; p = 0.032 vs. thyroiditis without simvastatin; #p = 0.008 vs. healthy donors; χ2-test

Fig. 13

Statins as immunomodulatory therapy in GO

On page 365, right column, bottom, and on page 366, left column, top, the sentence should read “….role in the pathogenesis of autoimmune thyroid disease, multiple sclerosis, rheumatoid arthritis, type 1 diabetes, and others.”

On page 368, Table 2, left column, under the heading “Criterion” the following typographical errors should be corrected to the vertical column:
  • Increased frequency…..

  • Increased responsiveness of IL-10…

  • Enhancements of upregulated…

On page 371, in Figure 13 the blue cell “Th” should be corrected to “Th1”.

On page 375, right column, middle section, the sentence should read “…in Table 8 revealed a statin-induced….

On page 386, the legend of Figure 23 at the end of the page should be corrected to “…whereas few unbalanced IL-17+IFN-gamma+ Th17/Th1 cells responding to peptide 9 were found….

On page 375 in Table 5 and on page 388 in Table 6 “Mal. weight” should be corrected to “Mol. weight”.

On page 389, in Table 7 the horizontal line under “Group” should be corrected as well as the table legend, see reprinted Table 7.

Notes

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Medicover GmbH BerlinBerlinGermany
  2. 2.Carl von Ossietzky UniversityOldenburgGermany
  3. 3.Technical University of DresdenDresdenGermany
  4. 4.University of LouisvilleLouisvilleUSA
  5. 5.University of Tennessee Health Science CenterMemphisUSA
  6. 6.University of GreifswaldGreifswaldGermany
  7. 7.Institute of Diabetes “Gerhardt Katsch”KarlsburgGermany

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