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Myo-inositol in autoimmune thyroiditis, and hypothyroidism

  • Poupak Fallahi
  • Silvia Martina Ferrari
  • Giusy Elia
  • Francesca Ragusa
  • Sabrina Rosaria Paparo
  • Claudia Caruso
  • Giovanni Guglielmi
  • Alessandro Antonelli
Article
  • 31 Downloads

Abstract

Myo-inositol (Myo-Ins) plays an important role in thyroid function and autoimmunity. Myo-Ins is the precursor for the synthesis of phosphoinositides, which takes part in the phosphatidylinositol (PtdIns) signal transduction pathway, and plays a decisive role in several cellular processes. In the thyroid cells, PtdIns is involved in the intracellular thyroid-stimulating hormone (TSH) signaling, via Phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P3) (PIP-3). Moreover, the phosphatidyl inositol 3 kinases (PI3K) family of lipid kinases regulates diverse aspects of T, B, and Tregs lymphocyte behaviour. Different mouse models deficient for the molecules involved in the PIP3 pathway suggest that impairment of PIP3 signaling leads to dysregulation of immune responses and, sometimes, autoimmunity. Studies have shown that cytokines modulate Myo-Ins in thyroid cells. Moreover, clinical studies have shown that after treatment with Myo-inositol plus seleniomethionine (Myo-Ins + Se), TSH levels significantly declined in patients with subclinical hypothyroidism due to autoimmune thyroiditis. The treatment was accompanied by a decline of antithyroid autoantibodies. After treatment serum CXCL10 levels declined, confirming the immune-modulatory effect of Myo-Ins. Additional research is necessary in larger population to evaluate the effect on the quality of life, and to study the mechanism of the effect on chemokines.

Keywords

Myo-inositol Seleniomethionine Autoimmune thyroiditis Hypothyroidism Autoimmune thyroid diseases CXCL10 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Research involving human participants

This article does not contain any studies with human participants or animals performed by any of the authors.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Poupak Fallahi
    • 1
  • Silvia Martina Ferrari
    • 2
  • Giusy Elia
    • 2
  • Francesca Ragusa
    • 2
  • Sabrina Rosaria Paparo
    • 2
  • Claudia Caruso
    • 2
  • Giovanni Guglielmi
    • 3
  • Alessandro Antonelli
    • 2
  1. 1.Department of Translational Research and New Technologies in Medicine and SurgeryUniversity of PisaPisaItaly
  2. 2.Department of Clinical and Experimental MedicineUniversity of Pisa, School of MedicinePisaItaly
  3. 3.U.O. Medicina Preventiva del LavoroAzienda Ospedaliero-Universitaria PisanaPisaItaly

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