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Low vitamin D status and obesity: Role of nutritionist

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Abstract

Low vitamin D status and obesity have concomitantly reached epidemic levels worldwide. Up to now the direction of the association between low vitamin D status and obesity, the exact mechanisms responsible for this association and the clinical usefulness to increase vitamin D status for reducing adiposity still warrant further evaluation. The aim of the present review was to examine the current evidence linking low vitamin D status and obesity in relation to the role of the nutritionist. On the one side, considering obesity as a causal factor, low sun exposure in obese individuals due to their sedentary lifestyle and less outdoor activity, vitamin D sequestration in adipose tissue, and volumetric dilution of ingested or cutaneously synthesized vitamin D3 in the large fat mass of obese patients, might represent some of the factors playing a major role in the pathogenesis of the low vitamin D status. On the other side, the expression of both vitamin D3 receptors and enzymes responsible for vitamin D3 metabolism in adipocytes depicted a role for the low vitamin D status per se in the development of obesity by modulating adipocyte differentiation and lipid metabolism. Nutritionists need to accurately address the aspects influencing the low vitamin D status in obesity and the vitamin D supplementation in obese individuals.

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Acknowledgements

We would like to acknowledge all the Collaborators of this review: Antonio Improta, Dr. Vincenza Grazia Mele and Dr. Lidia Albanese.

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Authors and Affiliations

  1. Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131, Naples, Italy

    Silvia Savastano & Annamaria Colao

  2. I.O.S. & COLEMAN Srl, 80011 Acerra, Naples, Italy

    Luigi Barrea, Maria Cristina Savanelli & Francesca Nappi

  3. IRCCS SDN, Napoli Via Gianturco 113, 80143, Naples, Italy

    Carolina Di Somma

  4. Department of Sports Science and Wellness, “Parthenope” University of Naples, Naples, Italy

    Francesco Orio

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  1. Silvia Savastano
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  2. Luigi Barrea
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  3. Maria Cristina Savanelli
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  4. Francesca Nappi
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  5. Carolina Di Somma
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  6. Francesco Orio
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  7. Annamaria Colao
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Correspondence to Annamaria Colao.

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Silvia Savastano and Luigi Barrea equally contributed to this work.

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Savastano, S., Barrea, L., Savanelli, M.C. et al. Low vitamin D status and obesity: Role of nutritionist. Rev Endocr Metab Disord 18, 215–225 (2017). https://doi.org/10.1007/s11154-017-9410-7

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