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Catch up growth in low birth weight infants: Striking a healthy balance

  • Vandana JainEmail author
  • Atul Singhal
Article

Abstract

Catch-up growth in the first few months of life is seen almost ubiquitously in infants born small for their gestational age and conventionally considered highly desirable as it erases the growth deficit. However, recently such growth has been linked to an increased risk of later adiposity, insulin resistance and cardiovascular disease in both low income and high-income countries. In India, a third of all babies are born with a low birth weight, but the optimal growth pattern for such infants is uncertain. As a response to the high rates of infectious morbidities, undernutrition and stunting in children, the current policy is to promote rapid growth in infancy. However, with socio-economic transition and urbanization making the Indian environment more obesogenic, and the increasing prevalence of type 2 diabetes and cardiovascular disease, affecting progressively younger population, the long term adverse programming effect of fast/excessive weight gain in infancy on later body composition and metabolism may outweigh short-term benefits. This review discusses the above issues focusing on the need to strike a healthy balance between the risks and benefits of catch-up growth in Indian infants.

Keywords

Catch-up growth Low birth weight Programming Small for gestational age Fat mass Insulin resistance 

References

  1. 1.
    Enas EA, Singh V, Munjal YP, Bhandari S, Yadave RD, Manchanda SC. Reducing the burden of coronary artery disease in India: challenges and opportunities. Indian Heart J. 2008;60:161–75.PubMedGoogle Scholar
  2. 2.
    Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27:1047–53.PubMedCrossRefGoogle Scholar
  3. 3.
    National Family Health Survey, India. 2009; http://www.nfhsindia.org/sub_report.shtml.
  4. 4.
    Misra A, Khurana L. Obesity and metabolic syndrome in developing countries. J Clin Endocrinol Metab. 2008;93:S9–S30.PubMedCrossRefGoogle Scholar
  5. 5.
    Deurenberg-Yap M, Schmidt G, van Staveren WA, Deurenberg P. The paradox of low body mass index and high body fat percentage among Chinese, Malays and Indians in Singapore. Int J Obes Relat Metab Disord. 2000;24:1011–7.PubMedCrossRefGoogle Scholar
  6. 6.
    Yajnik C, Yudkin JS. The Y-Y paradox. Lancet. 2004;363:163.PubMedCrossRefGoogle Scholar
  7. 7.
    Bhat DS, Yajnik CS, Sayyad MG, Raut KN, Lubree HG, Rege SS, et al. Body fat measurement in Indian men: comparison of three methods based on a two-compartment model. Int J Obes. 2005;29:842–8.CrossRefGoogle Scholar
  8. 8.
    Gluckman P, Hanson M. Maternal constraint of fetal growth and its consequences. Semin Fetal Neonatal Med. 2004;9:425.CrossRefGoogle Scholar
  9. 9.
    World Health Organization. Expert group on prematurity. Final report. Technical report, series 27. Geneva: World Health Organization; 1950.Google Scholar
  10. 10.
    Barker DJ, Osmond C, Golding J, Kuh D, Wadsworth ME. Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. BMJ. 1989;298:564–7.PubMedCrossRefGoogle Scholar
  11. 11.
    Barker DJ, Osmond C. Low birth weight and hypertension. BMJ. 1988;297:134–5.PubMedCrossRefGoogle Scholar
  12. 12.
    United Nations Children Fund, World Health Organization. Low Birth Weight: Country, Regional and Global Estimates 2004.Google Scholar
  13. 13.
    Hofvander Y. International comparisons of postnatal growth of low birthweight infants with special reference to differences between developing and affluent countries. Acta Paediatr Scand Suppl. 1982;296:14–8.PubMedCrossRefGoogle Scholar
  14. 14.
    Chhabra P, Sharma AK, Grover VL, Aggarwal OP. Prevalence of low birth weight and its determinants in an urban resettlement area of Delhi. Asia Pac J Public Health. 2004;16:95–8.PubMedCrossRefGoogle Scholar
  15. 15.
    Deodhar J, Jarad R. Study of the prevalence of and high risk factors for fetal malnutrition in term newborns. Ann Trop Paediatr. 1999;19:273–7.PubMedCrossRefGoogle Scholar
  16. 16.
    Malik S, Ghidiyal RG, Udani R, Waingankar P. Maternal biosocial factors affecting low birth weight. Indian J Pediatr. 1997;64:373–7.PubMedCrossRefGoogle Scholar
  17. 17.
    Ericson A, Eriksson M, Westerholm P, et al. Pregnancy outcome and social indicators in Sweden: the situation in a modern welfare state. Acta Paediatrica Scandinavica. 1984;73:69–74.PubMedCrossRefGoogle Scholar
  18. 18.
    Mikolajczyk RT. A global reference for fetal-weight and birthweight percentiles. Lancet. 2011;377:1855–61.PubMedCrossRefGoogle Scholar
  19. 19.
    Margetts BM, et al. Persistence of lower birth weight in second generation South Asian babies born in the United Kingdom. J Epidemiol Community Health. 2002;56:684–7.PubMedCrossRefGoogle Scholar
  20. 20.
    Dawson I, Golder RY, Jonas EG. Birthweight by gestational age and its effect on perinatal mortality in white and in Punjabi births. Br J Obs Gyn. 1982;89:896–9.CrossRefGoogle Scholar
  21. 21.
    Lee P, Chernausek S, Hokken-Koelega A, Czernichow P. International small for Gestational Age Advisory Board consensus development conference statement: management of short children born small for gestational age. Pediatrics. 2003;111:1253–61.PubMedCrossRefGoogle Scholar
  22. 22.
    Gardosi J. Fetal growth standards: individual and global perspectives. Lancet. 2011;377:1812–4.PubMedCrossRefGoogle Scholar
  23. 23.
    Tanner J. Growth from birth to two: a critical review. Acta Med Auxol. 1994;26:7–45.Google Scholar
  24. 24.
    Ong K, Ahmed M, Emmett P, Preece M, Dunger D. Association between postnatal catch-up growth and obesity in childhood: prospective cohort study. BMJ. 2000;320:971.CrossRefGoogle Scholar
  25. 25.
    Victora CG, Barros FC, Horta BL, Martorell R. Short-term benefits of catch-up growth for small-for-gestational-age infants. Int J Epidemiol. 2001;30:1325–30.PubMedCrossRefGoogle Scholar
  26. 26.
    Barker JPD. Trajectories of growth among children who have coronary events as adults. N Engl J Med. 2005;353:1802–9.PubMedCrossRefGoogle Scholar
  27. 27.
    Bhargava SK, Sachdev HS, Fall CH, Osmond C, Lakshmy R, Barker DJ, et al. Relation of serial changes in childhood body-mass index to impaired glucose intolerance in young adulthood. N Engl J Med. 2004;350:865–75.PubMedCrossRefGoogle Scholar
  28. 28.
    Oommen A, Vatsa M, Paul V, Aggarwal R. Breastfeeding practices of urban and rural mothers. Indian Pediatr. 2009;46:891–4.PubMedGoogle Scholar
  29. 29.
    Baird J, Fisher D, Lucas P, Kleijnen J, Roberts H, Law C. Being big or growing fast: systematic review of size and growth in infancy and later obesity. BMJ. 2005;331:929–31.PubMedCrossRefGoogle Scholar
  30. 30.
    Monteiro PO, Victora CG. Rapid growth in infancy and childhood and obesity in later life -a systematic review. Obes Rev. 2005;6:143–54.PubMedCrossRefGoogle Scholar
  31. 31.
    Ong KK, Loos RJ. Rapid infancy weight gain and subsequent obesity: systematic reviews and hopeful suggestions. Acta Paediatrica. 2006;95:904–8.PubMedCrossRefGoogle Scholar
  32. 32.
    Soto N, Bazaes R, Pena V, Salazar T, Avila A, Iniquez G, et al. Insulin sensitivity and secretion are related to catch-up growth in small-for-gestational-age infants at age 1 year: results from a prospective cohort. J Clin Endocrinol Metab. 2003;88:3645–50.PubMedCrossRefGoogle Scholar
  33. 33.
    Ekelund U, Ong K, Linne Y, Neovius M, Brage S, Dunger DB, et al. Association of weight gain in infancy and early childhood with metabolic risk in young adults. J Clin Endocrinol Metab. 2007;92:98–103.PubMedCrossRefGoogle Scholar
  34. 34.
    Belfort M, Rifas-Shiman S, Rich-Edwards J, Kleinman K, Gillman M. Size at birth, infant growth, and blood pressure at three years of age. J Pediatr. 2007;151:670–4.PubMedCrossRefGoogle Scholar
  35. 35.
    Taveras E, Rifas-Shiman S, Belfort M, Kleinman K, Oken E, Gillman M. Weight status in the first six months of life and obesity at 3 years of age. Pediatrics. 2009;123:1177–83.PubMedCrossRefGoogle Scholar
  36. 36.
    Ay L, Van Houten V, Steegers E, Hofman A, Witteman J, Jaddoe V, et al. Fetal and postnatal growth and body composition at 6 months of age. J Clin Endocrinol Metab. 2009;94:2023–30.PubMedCrossRefGoogle Scholar
  37. 37.
    Durmus B, Mook-Kanamori DO, Holzhauer S, Hofman A, van der Beek EM, Boehm G, et al. Growth in foetal life and infancy is associated with abdominal adiposity at the age of 2 years: the Generation R Study. Clin Endocrinol. 2010;72:633–40.CrossRefGoogle Scholar
  38. 38.
    Ibanez L, Ong K, Dunger DB, de Zegher F. Early development of adiposity and insulin resistance after catch-up weight gain in small for gestational age children. J Clin Endocrinol Metab. 2006;91:2153–8.PubMedCrossRefGoogle Scholar
  39. 39.
    Ibanez L, Lopez-Bermejo A, Suarez L, Marcos M, Diaz M, de Zegher F. Visceral adiposity without overweight in children born small for gestational age. J Clin Endocrinol Metab. 2008;93:2079–83.PubMedCrossRefGoogle Scholar
  40. 40.
    Singhal A, Lucas A. Early origins of cardiovascular disease: Is there a unifying hypothesis? Lancet. 2004;363:1642–5.PubMedCrossRefGoogle Scholar
  41. 41.
    Singhal A, Cole TJ, Fewtrell M, Kennedy K, Stephenson T, Elias-Jones A, et al. Promotion of faster weight gain in infants born small for gestational age: Is there an adverse effect on later blood pressure? Circulation. 2007;115:213–20.PubMedCrossRefGoogle Scholar
  42. 42.
    Singhal A, Kennedy K, Lanigan J, Fewtrell M, Cole TJ, Stephenson T, et al. Nutrition in infancy and long-term risk of obesity: evidence from two randomised controlled trials. Am J Clin Nutr. 2010;92:1133–44.PubMedCrossRefGoogle Scholar
  43. 43.
    Fall CH, Sachdev HS, Osmond C, Lakshmy R, Biswas SD, Prabhakaran D, et al. Adult metabolic syndrome and impaired glucose tolerance are associated with different patterns of BMI gain during infancy: data from the New Delhi Birth Cohort. Diabetes Care. 2008;31:2349–56.PubMedCrossRefGoogle Scholar
  44. 44.
    Gillman M, Rifas-Shiman S, Berkey C, Field A, Colditz G. Maternal gestational diabetes, birth weight, and adolescent obesity. Pediatrics. 2003;111:e221–6.PubMedCrossRefGoogle Scholar
  45. 45.
    Chomtho S, Wells JC, Williams JE, Davies PS, Lucas A, Fewtrell MS. Infant growth and later body composition: evidence from the 4-component model. Am J Clin Nutr. 2008;87:1776–84.PubMedGoogle Scholar
  46. 46.
    Leunissen RWJ, Kerkhof GF, Stijnen T, Hokken-Koelega A. Timing and tempo of first-year rapid growth in relation to cardiovascular and metabolic risk profile in early adulthood. JAMA. 2009;301:2234–42.PubMedCrossRefGoogle Scholar
  47. 47.
    Bansal N, Ayoola OO, Gemmell I, Vyas A, Koudsi A, Oldroyd J, et al. Effects of early growth on blood pressure of infants of British European and South Asian origin at one year of age: the Manchester children’s growth and vascular health study. J Hypertens. 2008;26:412–8.PubMedCrossRefGoogle Scholar
  48. 48.
    Cianfarani S, Germani D, Rossi P, Rossi L, Germani A, Ossicini C, et al. Intrauterine growth retardation (IUGR): evidence for the activation of the IGF-related growth promoting machinery and the presence of a cation-independent IGFBP-3 proteolytic activity by two months of life. Pediatr Res. 1998;44:374–80.PubMedCrossRefGoogle Scholar
  49. 49.
    Leger J, Noel M, Limal JM, Czernichow P. Growth factors and intrauterine growth retardation. II. Serum growth hormone, insulin-like growth factor-I, and IGF-binding protein-3 levels in children with intrauterine growth retardation compared with normal control subjects: prospective study from birth to two years of age. Pediatr Res. 1996;40:101–7.PubMedCrossRefGoogle Scholar
  50. 50.
    Cianfarani S, Germani D, Branca F. Low birthweight and adult insulin resistance: the “catch-up growth” hypothesis. Arch Dis Child Fetal Neonatal Ed. 1999;81:F71–3.PubMedCrossRefGoogle Scholar
  51. 51.
    Crescenzo R, Samec S, Antic V, Rohner-Jeanrenaud F, Seydoux J, Montani JP, et al. A role for suppressed thermogenesis favoring catch-up fat in the pathophysiology of catch-up growth. Diabetes. 2003;52:1090–7.PubMedCrossRefGoogle Scholar
  52. 52.
    Summermatter S, Marcelino H, Arsenijevic D, Buchala A, Aprikian O, Assimacopoulos-Jeannet F, et al. Adipose tissue plasticity during catch-up fat driven by thrifty metabolism: relevance for muscle-adipose glucose redistribution during catch-up growth. Diabetes. 2009;58:2228–37.PubMedCrossRefGoogle Scholar
  53. 53.
    Reaven GM. Pathophysiology of insulin resistance in human disease. Physiol Rev. 1995;75:473–86.PubMedGoogle Scholar
  54. 54.
    Yeung MY. Postnatal growth, neurodevelopment and altered adiposity after preterm birth–from a clinical nutrition perspective. Acta Paediatr. 2006;95:909–17.PubMedCrossRefGoogle Scholar
  55. 55.
    Arenz S, Ruckerl R, Koletzko B, von Kries R. Breastfeeding and childhood obesity: a systematic review. Int J Obes Relat Metab Disord. 2004;28:1247–56.PubMedCrossRefGoogle Scholar
  56. 56.
    Harder T, Bergmann R, Kallischnigg G, Plagemann A. Duration of breastfeeding and risk of overweight: a meta-analysis. Am J Epidemiol. 2005;162:397–403.PubMedCrossRefGoogle Scholar
  57. 57.
    Owen CG, Martin RM, Whincup PH, Smith GD, Cook DG. Effect of infant feeding on the risk of obesity across the life course: a quantitative review of published evidence. Pediatrics. 2005;115:1367–77.PubMedCrossRefGoogle Scholar
  58. 58.
    Koletzko B, von Kries R, Closa R, Escribano J, Scaglioni S, Giovannini M, et al. Can infant feeding choices modulate later obesity risk? Am J Clin Nutr. 2009;89:1502S–8S.PubMedCrossRefGoogle Scholar
  59. 59.
    Newburg DS, Woo JG, Morrow AL. Characteristics and potential functions of human milk adiponectin. J Pediatr. 2010;156:S41–6.PubMedCrossRefGoogle Scholar
  60. 60.
    Miralles O, Sánchez J, Palou A, Picó C. A physiological role of breast milk leptin in body weight control in developing infants. Obesity (Silver Spring). 2006;14:1371–7.CrossRefGoogle Scholar
  61. 61.
    Disantis KI, Collins BN, Fisher JO, Davey A. Do infants fed directly from the breast have improved appetite regulation and slower growth during early childhood compared with infants fed from a bottle? Int J Behav Nutr Phys Act. 2011;8:89.PubMedCrossRefGoogle Scholar
  62. 62.
    Durmuş B, Ay L, Duijts L, Moll HA, Hokken-Koelega AC, Raat H, et al. Infant diet and subcutaneous fat mass in early childhood: the Generation R Study. Eur J Clin Nutr. 2011. doi: 10.1038/ejcn.2011.174 [Epub ahead of print].
  63. 63.
    Clifton PM, Nestel PJ. Relationship between plasma insulin and erythrocyte fatty acid composition. Prostaglandins Leukot Essent Fatty Acids. 1998;59:191–4.PubMedCrossRefGoogle Scholar
  64. 64.
    Azain MJ. Role of fatty acids in adipocyte growth and development. J Anim Sci. 2004;82:916–24.PubMedGoogle Scholar
  65. 65.
    Ruzickova J, Rossmeisl M, Prazak T, et al. Omega-3 PUFA of marine origin limit diet-induced obesity in mice by reducing cellularity of adipose tissue. Lipids. 2004;39:1177–85.PubMedCrossRefGoogle Scholar
  66. 66.
    Chicco A, D’Aessandro ME, Karabatas L, Gutman R, Lombardo YB. Effect of moderate levels of dietary fish oil on insulin secretion and sensitivity, and pancrease insulin content in normal rats. Ann Nutri Metab. 1996;40:61–70.CrossRefGoogle Scholar
  67. 67.
    Yepuri G, Marcelino H, Shahkhalili Y, Aprikian O, Macé K, Seydoux J, et al. Dietary modulation of body composition and insulin sensitivity during catch-up growth in rats: effects of oils rich in n-6 or n-3 PUFA. Br J Nutr 2011;1–14. [Epub ahead of print]Google Scholar
  68. 68.
    Groh-Wargo S, Jacobs J, Auestad N, O’Connor DL, Moore JJ, Lerner E. Body composition in preterm infants who are fed long-chain polyunsaturated fatty acids: a prospective, randomized, controlled trial. Pediatr Res. 2005;57:712–8.PubMedCrossRefGoogle Scholar
  69. 69.
    Lauritzen L, Hoppe C, Straarup EM, Michaelsen KF. Maternal fish oil supplementation in lactation and growth during the first 2.5 years of life. Pediatr Res. 2005;58:235–42.PubMedCrossRefGoogle Scholar
  70. 70.
    Asserhoj M, Nehammer S, Matthiessen J, Michaelsen KF, Lauritzen L. Maternal fish oil supplementation during lactation may adversely affect long-term blood pressure, energy intake, and physical activity of 7-year-old boys. J Nutr. 2009;139:298–304.PubMedGoogle Scholar
  71. 71.
    Lucia Bergmann R, Bergmann KE, Haschke-Becher E, et al. Does maternal docosahexaenoic acid supplementation during pregnancy and lactation lower BMI in late infancy? J Perinat Med. 2007;35:295–300.PubMedCrossRefGoogle Scholar
  72. 72.
    Helland IB, Smith L, Blomen B, Saarem K, Saugstad OD, Drevon CA. Effect of supplementing pregnant and lactating mothers with n23 very-long-chain fatty acids on children’s IQ and body mass index at 7 years of age. Pediatrics. 2008;122:e472–9.PubMedCrossRefGoogle Scholar
  73. 73.
    Muhlhausler BS, Gibson RA, Makrides M. Effect of long-chain polyunsaturated fatty acid supplementation during pregnancy or lactation on infant and child body composition: a systematic review. Am J Clin Nutr. 2010;92:857–63.PubMedCrossRefGoogle Scholar
  74. 74.
    Clayton PE, et al. Management of the child born small for gestational age through to adulthood: a consensus statement of the International Societies of Pediatric Endocrinology and the Growth Hormone Research Society. J Clin Endocrinol Metab. 2007;92:804–10.PubMedCrossRefGoogle Scholar

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© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Division of Pediatric Endocrinology, Department of PediatricsAll India Institute of Medical SciencesNew DelhiIndia
  2. 2.MRC Childhood Nutrition Centre, Institute of Child HealthUCLLondonUK

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