Reviews in Endocrine and Metabolic Disorders

, Volume 11, Issue 3, pp 157–163

Pancreatic β-cell KATP channels: Hypoglycaemia and hyperglycaemia

Article

DOI: 10.1007/s11154-010-9144-2

Cite this article as:
Bennett, K., James, C. & Hussain, K. Rev Endocr Metab Disord (2010) 11: 157. doi:10.1007/s11154-010-9144-2

Abstract

The pancreatic β-cell ATP-sensitive K+ channel (KATP channel) plays a critical role in glucose homeostasis by linking glucose metabolism to electrical excitability and insulin secretion. Changes in the intracellular ratio of ATP/ADP mediate the metabolic regulation of channel activity. The β-cell KATP channel is a hetero-octameric complex composed of two types of subunits: four inward-rectifying potassium channel pore-forming (Kir6.2) subunits and four high-affinity sulfonylurea receptor 1 (SUR1) subunits. Kir6.2 and SUR1 are encoded by the genes KCNJ11 and ABCC8, respectively. Mutations in these genes can result in congenital hyperinsulinism and permanent neonatal diabetes. This review highlights the important role of the β-cell KATP channel in glucose physiology and provides an introduction to some of the other review articles in this special edition of the Reviews in Endocrine and Metabolic Disorders.

Keywords

KATP channel Sulphonylurea receptor Inwardly rectifying potassium channel Hyperinsulinism Hyperglycaemia Hypoglycaemia 

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Developmental Endocrinology Research Group, Clinical and Molecular Genetics Unit, Institute of Child HealthUniversity College LondonLondonUK
  2. 2.Great Ormond Street Hospital for Children NHS TrustLondonUK

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