Reaction Kinetics and Catalysis Letters

, Volume 95, Issue 2, pp 385–390

Copper(II) trifluoroacetate catalyzed synthesis of 3,4- dihydropyrimidin-2(1H)-ones under solvent-free conditions

  • Dailei Song
  • Runxia Wang
  • Yongli Chen
  • Shaohua Zhang
  • Chunsheng Liu
  • Genxiang Luo
Article

Abstract

A simple and effective synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives from aldehydes, 1,3-dicarbonyl compounds and urea using copper(II) trifluoroacetate as catalyst under solvent-free conditions is described. Compared with the classical Biginelli reaction condition, this new method has the advantage of good to excellent yields and short reaction time.

Keywords

3,4-dihydropyrimidin-2(1H)-ones copper(II) trifluoroacetate Biginelli reaction solvent-free 

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Copyright information

© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  • Dailei Song
    • 1
  • Runxia Wang
    • 1
  • Yongli Chen
    • 1
  • Shaohua Zhang
    • 1
  • Chunsheng Liu
    • 1
  • Genxiang Luo
    • 1
  1. 1.Department of Chemistry, School of Chemistry and Materials ScienceLiaoning Shihua UniversityFushunPeople’s Republic of China

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