Reaction Kinetics and Catalysis Letters

, Volume 88, Issue 2, pp 391–398 | Cite as

Continuous enantioselective hydrogenation of activated ketones on a pt-cd chiral catalyst: use of h-cube reactor system

  • György Szöllősi
  • Beáta Hermán
  • Ferenc Fülöp
  • and Mihály Bartók

Summary

The Pt-alumina-CD catalyzed enantioselective hydrogenations of ethylpyruvate (EP), ketopantolactone (KPL) and methyl benzoylformate (MBF) have been studied at first in an H-Cube flow hydrogenator in toluene and toluene + acetic acid. Based on the experience of previous studies carried out in batch-reactor and continuous flow systems, some parameters were kept constant (amount of catalyst, 380 mg; substrate concentration, 0.18 mol/L; temperature, 283 K), whereas others, namely chiral modifier (CD) concentration, hydrogen pressure and total liquid flow (TLF: substrate + modifier + solvent) were varied. In the course of enantioselective hydrogenation (R)-products were formed in excess: in the case of EP, KPL, MBF: 90, 60, 80 % enantioselectivities were obtained.

hydrogenation ethyl pyruvate Asymmetric ketopantolactone fixed-bed reactor methyl benzoylformate platinum-cinchonidine catalyst enantioselective 

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Copyright information

© Springer-Verlag/Akadémiai Kiadó 2006

Authors and Affiliations

  • György Szöllősi
    • 1
  • Beáta Hermán
    • 2
  • Ferenc Fülöp
    • 3
  • and Mihály Bartók
    • 4
  1. 1.Organic Catalysis Research Group, Department of Organic ChemistryOrganic Catalysis Research Group of the Hungarian Academy of Sciences, University of SzegedSzeged
  2. 2.Institute of Pharmaceutical Chemistry, University of Szeged
  3. 3.Institute of Pharmaceutical Chemistry, University of Szeged
  4. 4.Organic Catalysis Research Group of the Hungarian Academy of Sciences, University of Szeged; Department of Organic Chemistry, University of Szeged

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