Reconstruction of object location for diffuse fluorescence tomography on the basis of hybrid models of light scattering in biotissues

  • I. I. Fiks
  • M. Yu. Kirillin
  • E. A. Sergeeva
  • I. V. Turchin
Article
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We propose a new method for reconstructing the spatial distribution of fluorophore in a highly scattering object from its images obtained by the method of diffuse fluorescence tomography. This method is intended for diagnostics of the fluorophore-marked tumors and is based on the algebraic-reconstruction principle combined with a new theoretical model and simulation of light propagation in randomly scattering media, such as biotissues, by the Monte Carlo method. The model experiments show that for 18-mm thick objects, the developed method allows one to determine location of the geometric center of a fluorescent inhomogeneity and its transverse and longitudinal dimensions with accuracies of up to 0.5 and 1.5 mm, respectively.

Keywords

Monte Carlo Method Point Spread Function Light Propagation Reconstruction Accuracy Algebraic Reconstruction Technique 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media, Inc. 2011

Authors and Affiliations

  • I. I. Fiks
    • 1
  • M. Yu. Kirillin
    • 1
  • E. A. Sergeeva
    • 1
  • I. V. Turchin
    • 1
  1. 1.Institute of Applied Physics of the Russian Academy of SciencesNizhny NovgorodRussia

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