Health-related quality of life (HRQoL) associated with echinococcosis patients in Tibetan communities in Shiqu County, China: a case–control study



Echinococcosis is a chronic neglected zoonotic disease with high endemic in western China. The aim of the study was to evaluate the Health-related Quality of Life (HRQoL) in patients with echinococcosis in Tibetan communities for investigating the physical and mental health challenges faced by the echinococcosis patients and meeting community health needs.


The HRQoL was measured with 36-Item Short Form Health Survey (SF-36) questionnaire in the case–control study. Analysis of variance (ANOVA) method was used to analyze the data.


50 echinococcosis patients were collected in study group and divided into three subgroups by the duration of staying on albendazole tablets. 52 healthy individuals were collected in control group. In physical quality of life, the duration of staying on albendazole tables influenced the PF (F = 6.661, P < 0.001), RP (F = 3.130, P = 0.029), and GH (F = 4.105, P = 0.008). In mental quality of life, the duration of staying on albendazole tables influenced the SF (F = 10.764, P < 0.001) and RE (F = 5.573, P = 0.001). The income level was the important confounder in PF (F = 11.515, P = 0.001), GH (F = 10.315, P = 0.002), VT (F = 5.984, P = 0.016), and MH (F = 5.565, P = 0.020).


The HRQoL in people with echinococcosis is reduced in comparison with the healthy individuals. It is necessary to shorten the duration of treatment and adopt the special methods adapting the local culture to improve the health-related quality of life in Tibetan communities. Meanwhile, the economic improvement is the foundation.

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Availability of data and materials

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.


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We thank Shiqu County People’s Hospital and the local health workers for assistance in data collections.


This study was supported by the Science and Technology Project of Health Planning Committee of Sichuan (18PJ576).

Author information

ZY and SL supervised the study and helped revise drafts of the manuscript. XS conceived, designed the study and collected the data, finalized the analysis, and wrote the drafts of the manuscript. KL and HZ designed the study, wrote the drafts of the manuscript, and interpreted the findings. SZ, JY, JY, LK, RS, YW, YW, and YQ collected the data and analyzed the data. All authors read and approved the final manuscript.

Correspondence to Ze Yang or Hongbin Zhang.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of Ethics Committee of Affiliated Hospital, Chengdu University and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Shan, X., Chen, Y., Liu, K. et al. Health-related quality of life (HRQoL) associated with echinococcosis patients in Tibetan communities in Shiqu County, China: a case–control study. Qual Life Res (2020).

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  • Echinococcosis
  • HRQoL
  • Tibetan community