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Health-related quality of life (HRQoL) associated with echinococcosis patients in Tibetan communities in Shiqu County, China: a case–control study

Abstract

Purpose

Echinococcosis is a chronic neglected zoonotic disease with high endemic in western China. The aim of the study was to evaluate the Health-related Quality of Life (HRQoL) in patients with echinococcosis in Tibetan communities for investigating the physical and mental health challenges faced by the echinococcosis patients and meeting community health needs.

Methods

The HRQoL was measured with 36-Item Short Form Health Survey (SF-36) questionnaire in the case–control study. Analysis of variance (ANOVA) method was used to analyze the data.

Results

50 echinococcosis patients were collected in study group and divided into three subgroups by the duration of staying on albendazole tablets. 52 healthy individuals were collected in control group. In physical quality of life, the duration of staying on albendazole tables influenced the PF (F = 6.661, P < 0.001), RP (F = 3.130, P = 0.029), and GH (F = 4.105, P = 0.008). In mental quality of life, the duration of staying on albendazole tables influenced the SF (F = 10.764, P < 0.001) and RE (F = 5.573, P = 0.001). The income level was the important confounder in PF (F = 11.515, P = 0.001), GH (F = 10.315, P = 0.002), VT (F = 5.984, P = 0.016), and MH (F = 5.565, P = 0.020).

Conclusions

The HRQoL in people with echinococcosis is reduced in comparison with the healthy individuals. It is necessary to shorten the duration of treatment and adopt the special methods adapting the local culture to improve the health-related quality of life in Tibetan communities. Meanwhile, the economic improvement is the foundation.

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Availability of data and materials

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

References

  1. 1.

    Moro, P., & Schantz, P. M. (2009). Echinococcosis: A review. International Journal of Infectious Diseases,13(2), 125–133. https://doi.org/10.1016/j.ijid.2008.03.037.

  2. 2.

    Li, B., Quzhen, G., Xue, C.-Z., Han, S., Chen, W.-Q., Yan, X.-L., et al. (2019). Epidemiological survey of echinococcosis in Tibet Autonomous Region of China. Infectious Diseases of Poverty. https://doi.org/10.1186/s40249-019-0537-5.

  3. 3.

    Tian, T., Chun-Li, C., Wei-Ping, W., Tie-Wu, J., Men-Bao, Q., Yu-Wan, H., et al. (2018). Epidemiological characteristics of echinococcosis death cases in China from 2008 to 2016. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi = Chinese Journal of Schistosomiasis Control, 30(3), 282–288, doi:https://doi.org/10.16250/j.32.1374.2018064.

  4. 4.

    Baumann, S., Shi, R., Liu, W., Bao, H., Schmidberger, J., Kratzer, W., et al. (2019). Worldwide literature on epidemiology of human alveolar echinococcosis: A systematic review of research published in the twenty-first century. Infection,47(5), 703–727. https://doi.org/10.1007/s15010-019-01325-2.

  5. 5.

    Deplazes, P., Rinaldi, L., Alvarez Rojas, C. A., Torgerson, P. R., Harandi, M. F., Romig, T., et al. (2017). Global distribution of alveolar and cystic echinococcosis. Advances in Parasitology,95, 315–493. https://doi.org/10.1016/bs.apar.2016.11.001.

  6. 6.

    Wang, Z., Wang, X., & Liu, X. (2008). Echinococcosis in China, a review of the epidemiology of Echinococcus spp. EcoHealth,5(2), 115–126. https://doi.org/10.1007/s10393-008-0174-0.

  7. 7.

    Bingham, G. M., Larrieu, E., Uchiumi, L., Mercapide, C., Mujica, G., Del Carpio, M., et al. (2016). The economic impact of Cystic Echinococcosis in Rio Negro Province, Argentina. American Journal of Tropical Medicine and Hygiene,94(3), 615–625. https://doi.org/10.4269/ajtmh.15-0304.

  8. 8.

    Budke, C. M., Deplazes, P., & Torgerson, P. R. (2006). Global socioeconomic impact of cystic echinococcosis. Emerging Infectious Diseases,12(2), 296–303.

  9. 9.

    Burckhardt, C. S., & Anderson, K. L. (2003). The Quality of Life Scale (QOLS): Reliability, validity, and utilization. Health and Quality of Life Outcomes,1, 60.

  10. 10.

    Schmidberger, J., Weimer, H., Schlingeloff, P., Kratzer, W., Gruener, B., Barth, T. F. E., et al. (2019). Health-related quality of life in patients with alveolar echinococcosis: a cross-sectional study. Infection,47(1), 67–75. https://doi.org/10.1007/s15010-018-1219-0.

  11. 11.

    Schmidberger, J., Steinbach, J., Schlingeloff, P., Kratzer, W., & Grüner, B. (2019). Surgery versus conservative drug therapy in alveolar echinococcosis patients in Germany—A health-related quality of life comparison. Food and Waterborne Parasitology. https://doi.org/10.1016/j.fawpar.2019.e00057.

  12. 12.

    Craig, P. S., Giraudoux, P., Wang, Z. H., & Wang, Q. (2019). Echinococcosis transmission on the Tibetan Plateau. Advances in Parasitology,104, 165–246. https://doi.org/10.1016/bs.apar.2019.03.001.

  13. 13.

    Yu, W., Wang, Q., Liao, S., Zhong, B., Liu, L., & Huang, Y. (2018). Echinococcosis prevalence in humans in Shiqu County of Sichuan in 2017. Pre Med Information,34, 545–554.

  14. 14.

    Alonso, J., Ferrer, M., Gandek, B., Ware, J. E., Aaronson, N. K., Mosconi, P., et al. (2004). Health-related quality of life associated with chronic conditions in eight countries: Results from the International Quality of Life Assessment (IQOLA) Project. Quality of Life Research,13(2), 283–298.

  15. 15.

    Wang, H. (2000). The Chinese SF-36 Health Survey:Translation, Cultural Adaptation. Validation and Normalization: Master, Zhejiang University.

  16. 16.

    Gandek, B., Ware, J. E., Jr., Aaronson, N. K., Alonso, J., Apolone, G., Bjorner, J., et al. (1998). Tests of data quality, scaling assumptions, and reliability of the SF-36 in eleven countries: Results from the IQOLA Project. Journal of Clinical Epidemiology,51(11), 1149–1158.

  17. 17.

    Ware, J. E., Jr., Kosinski, M., Gandek, B., Aaronson, N. K., Apolone, G., Bech, P., et al. (1998). The factor structure of the SF-36 Health survey in 10 countries: Results from the IQOLA Project. Journal of Clinical Epidemiology,51(11), 1159–1165.

  18. 18.

    Keller, S. D., Ware, J. E., Jr., Bentler, P. M., Aaronson, N. K., Alonso, J., Apolone, G., et al. (1998). Use of structural equation modeling to test the construct validity of the SF-36 health survey in ten countries: Results from the IQOLA Project. Journal of Clinical Epidemiology,51(11), 1179–1188.

  19. 19.

    Kalantar, S. S., You, A. S., Norris, K. C., Nakata, T., Novoa, A., Juarez, K., et al. (2019). the impact of race and ethnicity upon health-related quality of life and mortality in dialysis patients. Kidney Medicine. https://doi.org/10.1016/j.xkme.2019.07.005.

  20. 20.

    Vechetova, G., Slovak, M., Kemlink, D., Hanzlikova, Z., Dusek, P., Nikolai, T., et al. (2018). The impact of non-motor symptoms on the health-related quality of life in patients with functional movement disorders. Journal of Psychosomatic Research,115, 32–37. https://doi.org/10.1016/j.jpsychores.2018.10.001.

  21. 21.

    Munsour, E. E., Awaisu, A., Ahmad Hassali, M. A., Dabbous, Z., Zahran, N., & Abdoun, E. (2019). Impact of customized-consumer medication information on health-related quality of life among patients with type 2 diabetes mellitus. Research in Social and Administrative Pharmacy. https://doi.org/10.1016/j.sapharm.2019.08.038.

  22. 22.

    Mokhtari, Z., Gheshlagh, R. G., & Kurdi, A. (2019). Health-related quality of life in Iranian patients with type 2 diabetes: An updated meta-analysis. Diabetes & Metabolic Syndrome: Clinical Research & Reviews,13(1), 402–407. https://doi.org/10.1016/j.dsx.2018.10.007.

  23. 23.

    Schantz, P. M. (2006). Progress in diagnosis, treatment and elimination of echinococcosis and cysticercosis. Parasitology International,55, S7–S13. https://doi.org/10.1016/j.parint.2005.11.050.

  24. 24.

    Brunetti, E., Kern, P., Vuitton, D. A., & Writing Panel, W.-I. (2010). Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans. Acta Tropica,114(1), 1–16. https://doi.org/10.1016/j.actatropica.2009.11.001.

  25. 25.

    Nikendei, C., Greinacher, A., Berkunova, A., Junghanss, T., & Stojkovic, M. (2019). Psychological burden and resilience factors in patients with Alveolar Echinococcosis—A cross-sectional study. PLoS Neglected Tropical Diseases,13(1), e0007082. https://doi.org/10.1371/journal.pntd.0007082.

  26. 26.

    Ito, A., Urbani, C., Jiamin, Q., Vuitton, D. A., Dongchuan, Q., Heath, D. D., et al. (2003). Control of echinococcosis and cysticercosis: A public health challenge to international cooperation in China. Acta Tropica,86(1), 3–17. https://doi.org/10.1016/s0001-706x(02)00269-3.

  27. 27.

    Tillyard, G., & DeGennaro, V., Jr. (2019). New methodologies for global health research: Improving the knowledge, attitude, and practice survey model through participatory research in Haiti. Qualitative Health Research,29(9), 1277–1286. https://doi.org/10.1177/1049732318816675.

  28. 28.

    Gottstein, B., Stojkovic, M., Vuitton, D. A., Millon, L., Marcinkute, A., & Deplazes, P. (2015). Threat of alveolar echinococcosis to public health—A challenge for Europe. Trends in Parasitology,31(9), 407–412. https://doi.org/10.1016/j.pt.2015.06.001.

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Acknowledgments

We thank Shiqu County People’s Hospital and the local health workers for assistance in data collections.

Funding

This study was supported by the Science and Technology Project of Health Planning Committee of Sichuan (18PJ576).

Author information

ZY and SL supervised the study and helped revise drafts of the manuscript. XS conceived, designed the study and collected the data, finalized the analysis, and wrote the drafts of the manuscript. KL and HZ designed the study, wrote the drafts of the manuscript, and interpreted the findings. SZ, JY, JY, LK, RS, YW, YW, and YQ collected the data and analyzed the data. All authors read and approved the final manuscript.

Correspondence to Ze Yang or Hongbin Zhang.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of Ethics Committee of Affiliated Hospital, Chengdu University and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Cite this article

Shan, X., Chen, Y., Liu, K. et al. Health-related quality of life (HRQoL) associated with echinococcosis patients in Tibetan communities in Shiqu County, China: a case–control study. Qual Life Res (2020). https://doi.org/10.1007/s11136-020-02424-6

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Keywords

  • Echinococcosis
  • HRQoL
  • Tibetan community