Assessing health-related quality of life in cancer survivors: factors impacting on EORTC QLU-C10D-derived utility values
To investigate the factors influencing EORTC QLQ-C30-derived EORTC QLU-C10D utility values across five cancer types (non-Hodgkin lymphoma, multiple myeloma, colorectal, thyroid, and prostate cancer) and a general population sample.
Data from the Dutch population-based patient-reported outcomes following initial treatment and long-term evaluation of survivorship (PROFILES) registry collected between 2009 and 2012 were used. EORTC QLQ-C30 data were used to estimate utility values by applying the EORTC QLU-C10D instrument using Australian utility weights. Regression analyses were conducted, within and across cancer type, to examine the factors influencing utility values, including patient- and cancer-specific factors, as well as the EORTC QLQ-C30 scale/item scores.
The mean utility value for the total cancer sample was 0.791 (SD 0.201), significantly lower than that from the general population (0.865, SD 0.165). Multiple myeloma patients had the lowest utility value at 0.663 (SD 0.244). Physical functioning, pain and nausea and vomiting were the health-related quality of life (HRQoL) domains with the greatest impact on utility values; cognitive functioning and dyspnea had the lowest impact. Of the demographic and clinical factors, unemployment for reasons other than retirement, age older than 75 years, number of comorbidities, and experience of symptoms all had a statistically significant negative impact on utility values.
This study is one of the first to apply the EORTC QLU-C10D to a heterogeneous group of cancer patients. Results can be used to more efficiently target care towards factors influencing HRQoL. Furthermore, it enhances our understanding of how the EORTC QLU-C10D performs across cancer types, supporting its use in cost–utility analyses.
KeywordsEORTC QLU-C10D Health-related quality of life Patient-reported outcomes Utility values Cancer
Compliance with ethical standards
Conflict of interest
This research was completed as part of a Masters research program for T van Gelder who was the recipient of expense reimbursement from the University of Technology (UTS) as part of his research placement. The following author(s) are employed by UTS: R De Abreu Lourenco, B Mulhern. R De Abreu Lourenco and B Mulhern also receive funding from Cancer Australia for the provision of health economic support services via the Cancer Research Economics Support Team.
Ethics approval for the conduct of this study was provided by the University of Technology Sydney Human Research Ethics Committee under the Centre for Health Economics Research and Evaluation Program Ethics (Ref No. 2015000135).
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