The association between heart failure hospitalization and self-reported domains of health
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We compared self-reported domains of health between patients who with vs. without a recent heart failure (HF) hospitalization.
We fielded a 59-item questionnaire that included the 12-item Kansas City Cardiomyopathy Questionnaire (KCCQ-12) to age/sex-matched groups of 2000 HF patients who had and had not had a recent HF hospitalization. We entered questionnaire responses and electronic medical record data into multivariable logistic regression models to identify independent associations with a HF hospitalization.
After two mailings, we received 468 completed questionnaires for response rate of 23.4%. Patients with a recent HF hospitalization had significantly lower scores on the KCCQ-12 Quality of Life (52.6 vs. 59.6, p = 0.016) and Social Limitations (48.4 vs. 55.5, p = 0.009) scales as well as the Clinical Summary Scale (50.8 vs. 55.3, p = 0.048) and Total KCCQ-12 score (49.6 vs. 56.8, p = 0.003). In sequential logistic regression models designed to achieve parsimony, Total KCCQ was a strong predictor of being in the recent hospitalization group. When using the KCCQ-12 sub-scales, the Social Limitations scale was a strong predictor of being in the recent hospitalization group.
After accounting for comorbidities and other risk factors, a HF hospitalization appears to profoundly limit social activities which can increase the risk of poor outcomes.
KeywordsHeart failure Social limitations Quality of life
The study was funded by Janssen Scientific Affairs. GAN received unrelated funding from Boehringer-Ingelheim and Merck & Co.
Compliance with ethical standards
Conflict of interest
JP and AP are employees of Janssen. DSS reports no conflicts of interest.
The study was reviewed and approved by the Kaiser Permanente Northwest Institutional Review Board.
Informed consent was obtained from all participants included in the study.
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