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The combined polymorphisms of interleukin-6-174GG genotype and interleukin-10 ATA haplotype are associated with a poor quality of life in patients with chronic hepatitis C

  • Diego Alves Vieira
  • Luciana Rodrigues da Cunha
  • Cliviany Borges da Silva
  • Maria Thereza Bastos Almeida
  • Adriana Dias Gomes
  • César Lúcio Lopes de FariaJr.
  • Rosângela Teixeira
  • Fernando Silva Neves
  • Gifone Aguiar Rocha
  • Fabrício Freire de Melo
  • Dulciene Maria de Magalhães Queiroz
  • Luciana Diniz SilvaEmail author
Article

Abstract

Purpose

Chronic hepatitis C (CHC) is associated with a decreased health-related quality of life (HRQOL). More recent studies have pointed toward a genetic basis of patient-reported quality of life outcomes. Taking into account that the influence of single-nucleotide polymorphisms (SNPs) on the HRQOL of CHC patients has not been studied, we investigated the combined IL10-1082G/A, − 819C/T, and − 592C/A SNPs, and IL6-174G/C SNP. We also evaluated the association between demographic, clinical, psychiatric, virological, and genetic variables with domains and summaries of HRQOL in CHC patients.

Methods

132 consecutive CHC patients and 98 controls underwent psychiatric evaluation by using the Mini International Neuropsychiatric Interview. HRQOL was assessed by a generic questionnaire, the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36), and by the specific Liver Disease Quality of Life Questionnaire (LDQOL). IL6 and IL10 polymorphisms were evaluated by Taqman SNP genotyping assay. Multivariate analysis was used to evaluate the associations.

Results

Major depressive disorder was associated with lower SF-36 and LDQOL scores in seven and ten domains, respectively. Diabetes and hypertension were also associated with reduced HRQOL. CHC patients carrying the combination of IL10 ATA haplotype/IL6-GG genotype had lower scores in the SF-36—physical functioning domain, and reduced scores in the LDQOL effects of liver disease on activities of daily living, quality of social interaction, and sexual function domains than the non-carriers of the combined haplotype/genotype.

Conclusion

This is the first study to demonstrate that combined IL6 high-producer GG genotype and IL10 low-producer ATA haplotype is associated with poorer HRQOL in CHC patients.

Keywords

Chronic hepatitis C Health-related quality of life IL6 gene polymorphism IL10 gene polymorphism 

Notes

Acknowledgements

Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil (CAPES), Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG) and Pró-Reitoria de Pesquisa da Universidade Federal de Minas Gerais, Brazil.

Compliance with ethical standards

Conflict of interest

The authors declare they have no conflict of interest.

Supplementary material

11136_2019_2129_MOESM1_ESM.doc (402 kb)
Supplementary material 1 (DOC 402 KB)

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Diego Alves Vieira
    • 1
    • 2
  • Luciana Rodrigues da Cunha
    • 1
  • Cliviany Borges da Silva
    • 1
  • Maria Thereza Bastos Almeida
    • 3
  • Adriana Dias Gomes
    • 4
  • César Lúcio Lopes de FariaJr.
    • 4
  • Rosângela Teixeira
    • 1
    • 5
  • Fernando Silva Neves
    • 2
  • Gifone Aguiar Rocha
    • 4
  • Fabrício Freire de Melo
    • 4
  • Dulciene Maria de Magalhães Queiroz
    • 4
  • Luciana Diniz Silva
    • 1
    • 5
    Email author
  1. 1.Faculdade de Medicina, Outpatient Clinic of Viral Hepatitis, Instituto Alfa de GastroenterologiaUniversidade Federal de Minas Gerais (UFMG)Belo HorizonteBrazil
  2. 2.Sciences Applied to Adult Health Care Post-Graduate Programme, Faculdade de MedicinaUniversidade Federal de Minas Gerais (UFMG)Belo HorizonteBrazil
  3. 3.Medical undergraduate student, Faculdade de MedicinaUniversidade Federal de Minas Gerais (UFMG)Belo HorizonteBrazil
  4. 4.Laboratory of Research in Bacteriology, Faculdade de MedicinaUniversidade Federal de Minas Gerais (UFMG)Belo HorizonteBrazil
  5. 5.Department of Internal Medicine, Faculdade de MedicinaUniversidade Federal de Minas Gerais (UFMG)Belo HorizonteBrazil

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