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Hearing loss and quality of life in survivors of paediatric CNS tumours and other cancers

  • Annette Weiss
  • Grit Sommer
  • Christina Schindera
  • Laura Wengenroth
  • Axel Karow
  • Manuel Diezi
  • Gisela Michel
  • Claudia E. Kuehni
  • Swiss Paediatric Oncology Group (SPOG)
Brief Communication

Abstract

Purpose

Hearing loss, a complication of cancer treatment, may reduce health-related quality of life (HRQoL), especially in childhood cancer survivors of central nervous system (CNS) tumours who often have multiple late effects. We examined the effect of hearing loss on HRQoL in young survivors of CNS and other childhood cancers.

Methods

Within the Swiss Childhood Cancer Survivor Study, we sent questionnaires about hearing loss and HRQoL (KIDSCREEN-27) to parents of survivors aged 8–15 years. We stratified the effect of hearing loss on HRQoL by cancer diagnosis, using multivariable logistic regression and adjusting for sociodemographic and clinical factors.

Results

Hearing loss was associated with impaired physical well-being [unadjusted estimated differences − 4.6 (CI − 9.2, − 0.1); adjusted − 4.0 (CI − 7.6, − 0.3)] and peers and social support [unadjusted − 6.7 (CI − 13.0, − 0.3); adjusted − 5.0 (CI − 10.5, 0.9)] scores in survivors of CNS tumours (n = 123), but not in children diagnosed with other cancers (all p-values > 0.20, n = 577).

Conclusion

Clinicians should be alert to signs of reduced physical well-being and impaired relationships with peers. Especially survivors of CNS tumours may benefit most from strict audiological monitoring and timely intervention to mitigate secondary consequences of hearing loss on HRQoL.

Keywords

Childhood cancer Ototoxicity Swiss Childhood Cancer Survivor Study Swiss Childhood Cancer Registry Late effects Cancer treatment 

Notes

Acknowledgements

We thank all childhood cancer survivors and families for participating in our survey. We thank the study team of the SCCSS (Rahel Kuonen, Rahel Kasteler, Jana Remlinger, Laura Wengenroth, Corina Rueegg, Cornelia Rebholz), data managers of the SPOG (Claudia Anderegg, Pamela Balestra, Nadine Beusch, Rosa-Emma Garcia, Franziska Hochreutener, Friedgard Julmy, Nadia Lanz, Rodolfo Lo Piccolo, Heike Markiewicz, Annette Reinberg, Renate Siegenthaler and Verena Stahel) and the team of the SCCR (Verena Pfeiffer, Katharina Flandera, Erika Brantschen-Berclaz, Shelagh Redmond, Meltem Altun, Parvinder Singh, Elisabeth Kiraly). We thank Kali Tal for her editorial suggestions. Swiss Paediatric Oncology Group (SPOG) Scientific Committee: Prof. Dr. med. R. Ammann, Bern; Dr. med. K. Scheinemann, Aarau; Prof. Dr. med. M. Ansari, Geneva; Prof. Dr. med. M. Beck Popovic, Lausanne; Dr. med. P. Brazzola, Bellinzona; Dr. med. J. Greiner, St. Gallen; Prof. Dr. med. M. Grotzer, Zurich; Dr. med. H. Hengartner, St. Gallen; Prof. Dr. med. T. Kuehne, Basel; Prof. Dr. med. J. Rössler, Bern; Prof. Dr. med. F. Niggli, Zurich; PD Dr. med. F. Schilling, Lucerne; Prof. Dr. med. N. von der Weid, Basel.

Funding

This study was supported by the Swiss Cancer League (Grant Nos: 3412-02-2014, 3886-02-2016), the Stiftung für Krebsbekämpfung (www.krebsbekaempfung.ch), Kinderkrebs Schweiz (www.kinderkrebs-schweiz.ch) and received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 602030. The work of the Swiss Childhood Cancer Registry is supported by the Swiss Paediatric Oncology Group (www.spog.ch), Schweizerische Konferenz der kantonalen Gesundheitsdirektorinnen und -direktoren (www.gdk-cds.ch), Swiss Cancer Research (www.krebsforschung.ch), Kinderkrebshilfe Schweiz (www.kinderkrebshilfe.ch), the Federal Office of Public Health (FOPH) and the Institute of Cancer Epidemiology and Registration (www.nicer.org). The funders of the Swiss Childhood Cancer Registry support the daily running of the registry and have not had and will not have any role in the design, conduct, interpretation, or publication of the Swiss Childhood Cancer Registry itself as well as the related research projects.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants accorded with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Ethics approval was granted by the Ethics Committee of the Canton of Bern to the SCCR and SCCSS (KEK-BE: 166/2014) and the SCCSS is registered at ClinicalTrials.gov (Identifier: NCT03297034).

Informed consent

Informed consent was obtained from all participants (parents and survivors) for registration in the SCCR and participation in the SCCSS survey.

Supplementary material

11136_2018_2021_MOESM1_ESM.pdf (120 kb)
Supplementary material 1 (PDF 120 KB)

References

  1. 1.
    Landier, W. (2016). Ototoxicity and cancer therapy. Cancer, 122(11), 1647–1658.  https://doi.org/10.1002/cncr.29779.CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Roland, L., Fischer, C., Tran, K., Rachakonda, T., Kallogjeri, D., & Lieu, J. (2016). Quality of life in children with hearing impairment: Systematic review and meta-analysis. Otolaryngol Head Neck Surg.  https://doi.org/10.1177/0194599816640485.CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Lin, C.-Y., & Fung, X. (2018). The impact of environmental support on health for children with hearing impairment in Taiwan. Social Health and Behavior, 1(1), 4–10.  https://doi.org/10.4103/shb.shb_12_18.CrossRefGoogle Scholar
  4. 4.
    Gurney, J. G., Tersak, J. M., Ness, K. K., Landier, W., Matthay, K. K., Schmidt, M. L., et al. (2007). Hearing loss, quality of life, and academic problems in long-term neuroblastoma survivors: A report from the Children’s Oncology Group. [Comparative Study Research Support, N.IH., Extramural Research Support, Non-U.S. Gov’t]. Pediatrics, 120(5), e1229–e1236.  https://doi.org/10.1542/peds.2007-0178. [).CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Wengenroth, L., Gianinazzi, M. E., Rueegg, C. S., Luer, S., Bergstraesser, E., Kuehni, C. E., et al. (2015). Health-related quality of life in young survivors of childhood cancer. Quality of Life Research, 24(9), 2151–2161.  https://doi.org/10.1007/s11136-015-0961-3.CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    Laverdiere, C., Cheung, N. K., Kushner, B. H., Kramer, K., Modak, S., LaQuaglia, M. P., et al. (2005). Long-term complications in survivors of advanced stage neuroblastoma. Pediatric Blood and Cancer, 45(3), 324–332.  https://doi.org/10.1002/pbc.20331.CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Portwine, C., Rae, C., Davis, J., Teira, P., Schechter, T., Lewis, V., et al. (2016). Health-related quality of life in survivors of high-risk neuroblastoma after stem cell transplant: A national population-based perspective. Pediatric Blood and Cancer, 63(9), 1615–1621.  https://doi.org/10.1002/pbc.26063.CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    Weiss, A., Kuonen, R., Brockmeier, H., Grotzer, M., Candreia, C., Maire, R., et al. (2018). Audiological monitoring in Swiss childhood cancer patients. Pediatric Blood and Cancer.  https://doi.org/10.1002/pbc.26877.CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Children’s Oncology Group (2013). Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent and Young Adult Cancers, Version 4.0. http://www.survivorshipguidelines.org.
  10. 10.
    Kuehni, C. E., Rueegg, C. S., Michel, G., Rebholz, C. E., Strippoli, M. P., Niggli, F. K., et al. (2012). Cohort profile: The Swiss childhood cancer survivor study [Research Support, Non-U.S. Gov’t]. International Journal of Epidemiology, 41(6), 1553–1564,  https://doi.org/10.1093/ije/dyr142.CrossRefPubMedPubMedCentralGoogle Scholar
  11. 11.
    Michel, G., von der Weid, N. X., Zwahlen, M., Adam, M., Rebholz, C. E., Kuehni, C. E., et al. (2007). The Swiss Childhood Cancer Registry: Rationale, organisation and results for the years 2001–2005. [Research Support, Non-U.S Gov’t]. Swiss Medical Weekly, 137(35–36), 502–509.PubMedPubMedCentralGoogle Scholar
  12. 12.
    Schindler, M., Mitter, V., Bergstraesser, E., Gumy-Pause, F., Michel, G., & Kuehni, C. E. (2015). Death certificate notifications in the Swiss Childhood Cancer Registry: Assessing completeness and registration procedures. Swiss Medical Weekly, 145, w14225.  https://doi.org/10.4414/smw.2015.14225.CrossRefPubMedPubMedCentralGoogle Scholar
  13. 13.
    Ravens-Sieberer, U., & Europe, K. G. (2006). The Kidscreen questionnaires: Quality of life questionnaires for children and adolescents; handbook. Lengerich: Pabst Science Publ.Google Scholar
  14. 14.
    Ravens-Sieberer, U., Auquier, P., Erhart, M., Gosch, A., Rajmil, L., Bruil, J., et al. (2007). The KIDSCREEN-27 quality of life measure for children and adolescents: Psychometric results from a cross-cultural survey in 13 European countries. Quality of Life Research, 16(8), 1347–1356.  https://doi.org/10.1007/s11136-007-9240-2.CrossRefGoogle Scholar
  15. 15.
    Jervaeus, A., Kottorp, A., & Wettergren, L. (2013). Psychometric properties of KIDSCREEN-27 among childhood cancer survivors and age matched peers: A Rasch analysis. Health and Quality of Life Outcomes, 11, 96.  https://doi.org/10.1186/1477-7525-11-96.CrossRefPubMedPubMedCentralGoogle Scholar
  16. 16.
    Jervaeus, A., Lampic, C., Johansson, E., Malmros, J., & Wettergren, L. (2014). Clinical significance in self-rated HRQoL among survivors after childhood cancer—Demonstrated by anchor-based thresholds. Acta Oncology, 53(4), 486–492.  https://doi.org/10.3109/0284186x.2013.844852.CrossRefGoogle Scholar
  17. 17.
    Bisegger, C., Cloetta, B., & Europe Kidscreen Group (2005). Kidscreen: Fragebogen zur Erfassung der gesundheitsbezogenen Lebensqualität von Kindern und Jugendlichen. Manual der deutschsprachigen Versionen für die Schweiz. Bern: Universität Bern, Abteilung Gesundheitsforschung des Instituts für Sozial- und Präventivmedizin.Google Scholar
  18. 18.
    Steliarova-Foucher, E., Stiller, C., Lacour, B., & Kaatsch, P. (2005). International Classification of Childhood Cancer, third edition. [Research Support, Non-U.S. Gov’t]. Cancer, 103(7), 1457–1467.  https://doi.org/10.1002/cncr.20910.CrossRefPubMedPubMedCentralGoogle Scholar
  19. 19.
    Fuemmeler, B. F., Elkin, T. D., & Mullins, L. L. (2002). Survivors of childhood brain tumors: Behavioral, emotional, and social adjustment. Clinical Psychology Review, 22(4), 547–585.CrossRefPubMedCentralGoogle Scholar
  20. 20.
    Hocking, M. C., McCurdy, M., Turner, E., Kazak, A. E., Noll, R. B., Phillips, P., et al. (2015). Social competence in pediatric brain tumor survivors: Application of a model from social neuroscience and developmental psychology. Pediatric Blood & Cancer, 62(3), 375–384.  https://doi.org/10.1002/pbc.25300.CrossRefGoogle Scholar
  21. 21.
    Schulte, F., Wurz, A., Reynolds, K., Strother, D., & Dewey, D. (2016). Quality of life in survivors of pediatric cancer and their siblings: The consensus between parent-proxy and self-reports. Pediatric Blood & Cancer, 63(4), 677–683.  https://doi.org/10.1002/pbc.25868.CrossRefGoogle Scholar
  22. 22.
    van Dijk, J., Huisman, J., Moll, A. C., Schouten-van Meeteren, A. Y., Bezemer, P. D., Ringens, P. J., et al. (2007). Health-related quality of life of child and adolescent retinoblastoma survivors in the Netherlands. Health and Quality Life Outcomes, 5, 65.  https://doi.org/10.1186/1477-7525-5-65.CrossRefGoogle Scholar
  23. 23.
    Matziou, V., Perdikaris, P., Feloni, D., Moschovi, M., Tsoumakas, K., & Merkouris, A. (2008). Cancer in childhood: Children’s and parents’ aspects for quality of life. European Journal of Oncology Nursing, 12(3), 209–216.  https://doi.org/10.1016/j.ejon.2007.10.005.CrossRefPubMedPubMedCentralGoogle Scholar
  24. 24.
    Laffond, C., Dellatolas, G., Alapetite, C., Puget, S., Grill, J., Habrand, J. L., et al. (2012). Quality-of-life, mood and executive functioning after childhood craniopharyngioma treated with surgery and proton beam therapy. Brain Injury, 26(3), 270–281.  https://doi.org/10.3109/02699052.2011.648709.CrossRefPubMedPubMedCentralGoogle Scholar
  25. 25.
    Weiss, A., Sommer, G., Kuonen, R., Scheinemann, K., Grotzer, M., Kompis, M., et al. (2017). Validation of questionnaire-reported hearing with medical records: A report from the Swiss Childhood Cancer Survivor Study. PLoS ONE, 12(3), e0174479.  https://doi.org/10.1371/journal.pone.0174479.CrossRefPubMedPubMedCentralGoogle Scholar
  26. 26.
    Louie, A. D., Robison, L. L., Bogue, M., Hyde, S., Forman, S. J., & Bhatia, S. (2000). Validation of self-reported complications by bone marrow transplantation survivors. Bone Marrow Transplant, 25(11), 1191–1196.  https://doi.org/10.1038/sj.bmt.1702419.CrossRefPubMedPubMedCentralGoogle Scholar
  27. 27.
    Brinkman, T. M., Bass, J. K., Li, Z., Ness, K. K., Gajjar, A., Pappo, A. S., et al. (2015). Treatment-induced hearing loss and adult social outcomes in survivors of childhood CNS and non-CNS solid tumors: Results from the St. Jude Lifetime Cohort Study. Cancer, 121(22), 4053–4061.  https://doi.org/10.1002/cncr.29604.CrossRefPubMedPubMedCentralGoogle Scholar
  28. 28.
    Engelen, V., Koopman, H. M., Detmar, S. B., Raat, H., van de Wetering, M. D., Brons, P., et al. (2011). Health-related quality of life after completion of successful treatment for childhood cancer. Pediatric Blood & Cancer, 56(4), 646–653.  https://doi.org/10.1002/pbc.22795.CrossRefGoogle Scholar
  29. 29.
    Barrera, M., Shaw, A. K., Speechley, K. N., Maunsell, E., & Pogany, L. (2005). Educational and social late effects of childhood cancer and related clinical, personal, and familial characteristics. Cancer, 104(8), 1751–1760.  https://doi.org/10.1002/cncr.21390.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Swiss Childhood Cancer Registry, Institute of Social and Preventive MedicineUniversity of BernBernSwitzerland
  2. 2.Department for Epidemiology and Preventive Medicine/Medicine SociologyUniversity of RegensburgRegensburgGermany
  3. 3.Division of Pediatric Hematology/Oncology, Department of Pediatrics, InselspitalBern University Hospital, University of BernBernSwitzerland
  4. 4.Institute and Outpatient Clinic for Occupational, Social and Environmental MedicineUniversity Hospital of Munich (LMU)MunichGermany
  5. 5.Paediatric Haemato-Oncology Unit, Department of PaediatricsUniversity Hospital Lausanne (CHUV)LausanneSwitzerland
  6. 6.Department of Health Sciences and Health PolicyUniversity of LucerneLucerneSwitzerland

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