Quality of Life Research

, Volume 26, Issue 3, pp 727–736 | Cite as

Affective disorders and Health-Related Quality of Life (HRQoL) in adolescents and young adults with Multiple Sclerosis (MS): the moderating role of resilience

  • Nunzia RainoneEmail author
  • Alessandro Chiodi
  • Roberta Lanzillo
  • Valeria Magri
  • Anna Napolitano
  • Vincenzo Brescia Morra
  • Paolo Valerio
  • Maria Francesca Freda



To investigate the moderating role of resilience in the relationship between affective disorders and Health-Related Quality of Life (HRQoL) for adolescents and young adults with multiple sclerosis (MS).


A quantitative methodology was adopted. Fifty-three adolescents and young adults were interviewed to assess resilience as a personality trait (Ego-Resiliency Scale) and resilience as an interactive competence (CYRM-28), Health-Related Quality of Life (PedsQL 4.0), depression and anxiety (BDI-II and STAI-Y).


Affective disorders, both depression (β = −.38, p < .001) and anxiety (State β = –.35, p < .001; Trait β = −.41, p < .001), were negatively associated with HRQoL. Data also showed that the resilience competencies using Individual (β = .22, p < .001) and relational resources (β = .12, p < .05) are significantly associated HRQoL. According to the regression analyses, we tested the moderating role of resilience competence using individual resources on the relationship between the Depression Cognitive Factor and Emotional Functioning. Data show that in step 2 of the regression analysis, we obtained a variation of β = −.45 (p < .001) to β = −.30 (p < .001) in the dimension for the Depression Cognitive Factor. The Sobel test showed that the moderating effect of resilience was significant regarding the increase in R2 (p < .01).


Resilience competence using individual resources moderates the relationship between the Depression Cognitive Factor and Emotional Functioning in adolescents with MS. Our study suggests that to improve well-being for adolescents with MS resilience could play a key role.


Health-Related Quality of Life Resilience Affective disorders Adolescence and young adulthood Multiple sclerosis 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in this study were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. The University of Naples Federico II Ethics board also approved the study.

Informed consent

Written informed consent was obtained from all individuals included in the study or their parents as appropriate.


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Department of HumanitiesUniversity of Naples “Federico II”NaplesItaly
  2. 2.Department of Neurosciences, Reproductive Science and OdontostomatologyFederico II UniversityNaplesItaly

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