Quality of Life Research

, Volume 25, Issue 6, pp 1495–1504 | Cite as

The impact of taste and smell alterations on quality of life in head and neck cancer patients

  • M. Alvarez-Camacho
  • S. Gonella
  • S. Ghosh
  • C. Kubrak
  • R. A. Scrimger
  • K. P. Chu
  • W. V. Wismer
Article

Abstract

Purpose

Taste and smell alterations (TSAs) are among the most frequent and troublesome symptoms reported by head and neck cancer (HNC) patients after treatment. Little is known about the relationship between TSAs and quality of life (QoL) among HNC patients. The aim of this study was to determine the effect of TSAs on overall QoL among tube-fed and orally fed HNC patients before treatment, at end of treatment and at 2.5-month follow-up.

Methods

Data were collected in a longitudinal study prior to treatment (n = 126), at end of treatment (n = 100) and at 2.5-month follow-up (n = 85). Chemosensory Complaint Score (CCS) and the University of Washington Quality of Life Questionnaire version 3 were used to assess TSAs and QoL, respectively. Generalized estimated equation modeling was used to estimate the effect of CCS on QoL.

Results

At end of treatment, QoL and CCS had declined for both tube-fed and orally fed patients and thereafter improved, but not to pre-treatment levels. Neither QoL nor CCS mean scores were different between the two groups at any time point. CCS was a significant predictor of overall QoL (β = −1.82, p < 0.0001), social-emotional (β = −1.76, p < 0.0001), physical (β = −1.12, p < 0.0001) and overall functions (β = −1.15, p < 0.0001) at a multivariate level. Taste was reported as an important symptom for both tube-fed and orally fed groups at end of treatment and follow-up.

Conclusions

TSAs are an important symptom and an independent predictor of QoL for both tube-fed and orally fed HNC patients. HNC patients need support to manage TSAs, regardless of the method of nutritional intake.

Keywords

Head and neck cancer Quality of life Taste Smell Radiation therapy Self-report Tube feeding 

Notes

Acknowledgments

The authors thank Asifa Mawani for her help with data collection, Danielle Wiese, Michelle Wong and Lindsay Gervais for their support with data entry and food records analysis and financial support from the Canadian Institutes of Health Research (CIHR) and Alberta Cancer Foundation (ACF) (WW), Secretaría de Educación Pública (SEP), the Government of Mexico and Consejo Nacional de Ciencia y Tecnología (CONACyT Mexico) (MAC).

Author contributions

Mirey Alvarez-Camacho, Silvia Gonella and Sunita Ghosh contributed to conception and design; Wendy V. Wismer financially supported the article; Rufus A. Scrimger and Karen P. Chu contributed to provision of study materials or patients; Mirey Alvarez-Camacho and Catherine Kubrak contributed to collection and assembly of data; Mirey Alvarez-Camacho, Silvia Gonella and Sunita Ghosh analyzed and interpreted the data; Mirey Alvarez Camacho, Silvia Gonella and Wendy Wismer wrote the manuscript ; Mirey Alvarez Camacho, Silvia Gonella, Sunita Ghosh, Catherine Kubrak, Rufus A. Scrimger, Karen P. Chu and Wendy V. Wismer finally approved the manuscript.

Compliance with ethical standards

Conflict of interest

The authors have no conflict of interest to declare.

Supplementary material

11136_2015_1185_MOESM1_ESM.docx (26 kb)
Supplementary material 1 (DOCX 26 kb)

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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • M. Alvarez-Camacho
    • 1
  • S. Gonella
    • 2
    • 3
  • S. Ghosh
    • 4
  • C. Kubrak
    • 5
    • 6
  • R. A. Scrimger
    • 7
  • K. P. Chu
    • 7
  • W. V. Wismer
    • 1
  1. 1.Department of Agricultural, Food and Nutritional ScienceUniversity of AlbertaEdmontonCanada
  2. 2.Dipartimento di Sanità Pubblica e Medicina di ComunitàUniversità degli Studi di VeronaVeronaItaly
  3. 3.Dipartimento di Scienze della Sanità Pubblica e PediatricheUniversità degli Studi di TorinoTurinItaly
  4. 4.Division of Medical Oncology, Department of OncologyUniversity of AlbertaEdmontonCanada
  5. 5.Department of SurgeryUniversity of Alberta HospitalEdmontonCanada
  6. 6.Outpatient DepartmentRoyal Alexandra HospitalEdmontonCanada
  7. 7.Department of Radiation OncologyCross Cancer InstituteEdmontonCanada

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