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Psychometric analysis of the Korean version of the high-dose chemotherapy specific quality of life questionnaire module from the European Organization for Research and Treatment of Cancer (EORTC QLQ-HDC29)

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Abstract

Purpose

We evaluated the psychometric properties of the Korean version of the European Organization for Research and Treatment of Cancer high-dose chemotherapy specific quality of life questionnaire module (EORTC QLQ-HDC29) when implemented with Korean patients by conducting a multicenter, longitudinal study in three Korean hospitals.

Methods

A total of 226 patients who scheduled to receive the HDC followed by hematopoietic stem cell transplantation (HSCT) were enrolled. The patients were asked to complete three questionnaires [the EORTC Core Questionnaire (QLQ-C30), QLQ-HDC29, and the Functional Assessment of Cancer Therapy-Bone Marrow Transplantation] at four points in time: before HSCT and 100, 180, and 365 days after HSCT. Standard validity and reliability analyses were performed.

Results

Internal consistency of the QLQ-HDC29 was generally acceptable, as tested by Cronbach’s α, except for the scales body image and the inpatient issues. Cronbach’s α values for the Korean version of the QLQ-HDC29 were almost in accordance with results of the original version, except for the scales body image (lower to the original QLQ-HDC29, α = 0.73) and impact on family (higher to the original QLQ-HDC29, α = 0.52). Known-group comparison analyses showed significantly higher symptom burdens in patients with poor performance status or graft versus host disease (similar to the original QLQ-HDC29). The QLQ-HDC29 indicated good convergent and discriminant validity and showed responsiveness to changes in line with a clinical course over time after HSCT.

Conclusions

The QLQ-HDC29 is generally reliable and adequate to assess QoL in Korean patients undergoing HDC followed by HSCT.

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Acknowledgments

We thank the EORTC QOL Group for their supervision during the entire process to conduct the validation for the Korean version of the QLQ-HDC29 module.

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Authors and Affiliations

  1. College of Pharmacy, Korea University, Sejong, Republic of Korea

    Kyung Im Kim

  2. College of Pharmacy, Seoul National University, Seoul, Republic of Korea

    Jae Hyun Kim & Jung Mi Oh

  3. College of Pharmacy, Gachon University, Incheon, Republic of Korea

    Eun Hee Ji

  4. Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

    Jun Ho Jang

  5. Division of Hematology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

    Jin Seok Kim

  6. Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Republic of Korea

    Ji-Hyun Kwon

  7. Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea

    Inho Kim, Seonyang Park & Sung-Soo Yoon

  8. Cancer Research Institute, Seoul National University, Seoul, Republic of Korea

    Inho Kim, Seonyang Park & Sung-Soo Yoon

  9. Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea

    Inho Kim, Seonyang Park & Sung-Soo Yoon

  10. Cancer Research UK Clinical Centre – Leeds, St James’s University Hospital, Leeds, UK

    Galina Velikova

  11. Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea

    Jung Mi Oh

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  1. Kyung Im Kim
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Corresponding authors

Correspondence to Sung-Soo Yoon or Jung Mi Oh.

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All of the authors have declared no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Kim, K.I., Kim, J.H., Ji, E.H. et al. Psychometric analysis of the Korean version of the high-dose chemotherapy specific quality of life questionnaire module from the European Organization for Research and Treatment of Cancer (EORTC QLQ-HDC29). Qual Life Res 25, 881–890 (2016). https://doi.org/10.1007/s11136-015-1121-5

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  • DOI: https://doi.org/10.1007/s11136-015-1121-5

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