Quality of Life Research

, Volume 24, Issue 12, pp 2951–2957 | Cite as

Association of different levels of depressive symptoms with symptomatology, overall disease severity, and quality of life in women with fibromyalgia

  • Alberto Soriano-MaldonadoEmail author
  • Kirstine Amris
  • Francisco B. Ortega
  • Víctor Segura-Jiménez
  • Fernando Estévez-López
  • Inmaculada C. Álvarez-Gallardo
  • Virginia A. Aparicio
  • Manuel Delgado-Fernández
  • Marius Henriksen
  • Jonatan R. Ruiz
Brief Communication



This study examined the associations of different levels of depression with pain, sleep quality, fatigue, functional exercise capacity, overall fibromyalgia (FM) severity, and health-related quality of life (HRQoL) in women with FM.


A total of 451 women with FM participated in this cross-sectional study. Depressive symptoms (Beck Depression Inventory; BDI-II), pain intensity (numerical rating scale; NRS), pain sensitivity (algometry), sleep quality (Pittsburgh Sleep Quality Index), fatigue (Multidimensional Fatigue Inventory), functional exercise capacity (6-min walk test), FM severity (revised Fibromyalgia Impact Questionnaire), and HRQoL (SF-36) were assessed.


Participants with severe depressive symptoms had significantly higher pain intensity (NRS = 1.1; 95 % CI 0.3–1.8), fatigue (12.6-units; 95 % CI 8.2–17.1) and overall FM severity (12.6-units; 95 % CI 11.4–23.7), as well as poorer sleep quality (3.2-units; 95 % CI 1.7–4.7) and mental component of HRQoL (−17.0-units; 95 % CI −21.0 to −12.9) than participants with minimal signs of depression. There was no association of signs of depression with pain sensitivity, exercise capacity, or the physical component of HRQoL (P > 0.05).


These results extend current knowledge on the association of signs of depression with FM severity and quality of life in women with FM, and suggest that severity of depressive symptoms could potentially be a prognostic factor to be considered in future prospective intervention studies.


Chronic pain Depression Mental health Fatigue Physical function Health-related quality of life 



The authors would like to thank all the members from the CTS-545 Research Group involved in the field work. All participants involved in the study are also gratefully acknowledged. This work was supported by the Spanish Ministry of Science and Innovation [I + D + I DEP2010-15639], and Consejería de Turismo, Comercio y Deporte (CTCD-201000019242-TRA). AS-M (grant number: FPU12/00963) and VS-J (grant number: AP2010-0963) were supported by Grants from the Spanish Ministry of Education, Culture and Sport. ICA-G [grant number: BES-2011-047133], FE-L [grant number: BES-2014-067612], JRR (grant number: RYC-2010-05957) and FBO (grant number: RYC-2011-09011) were supported by the Spanish Ministry of Economy and Competitiveness. VAA was supported by the Andalucia Talent Hub Fellowship, funded by the Andalusian Ministry of Economy, Innovation, Science and Employment and the EU 7th Framework Program via the Marie Curie Action, “Co-funding of Regional, National and International Programs”. M.H and K.A were supported by the OAK Foundation. The founding sources had no role in any stage of the study. The results of this article are likely to be included in the Doctoral Thesis from AS-M in the context of the Biomedicine Doctoral Program at the University of Granada.

Conflict of interest



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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Alberto Soriano-Maldonado
    • 1
    Email author
  • Kirstine Amris
    • 2
  • Francisco B. Ortega
    • 1
  • Víctor Segura-Jiménez
    • 1
  • Fernando Estévez-López
    • 1
    • 3
  • Inmaculada C. Álvarez-Gallardo
    • 1
  • Virginia A. Aparicio
    • 1
    • 4
    • 5
  • Manuel Delgado-Fernández
    • 1
  • Marius Henriksen
    • 2
  • Jonatan R. Ruiz
    • 1
  1. 1.Department of Physical Education and Sport, Faculty of Sport SciencesUniversity of GranadaGranadaSpain
  2. 2.Department of Rheumatology, The Parker InstituteCopenhagen University Hospital Bispebjerg and FrederiksbergFrederiksbergDenmark
  3. 3.Department of Clinical and Health Psychology, Faculty of Social and Behavioural SciencesUtrecht UniversityUtrechtThe Netherlands
  4. 4.Department of Physiology, Faculty of Pharmacy, and Institute of Nutrition and Food TechnologyUniversity of GranadaGranadaSpain
  5. 5.Department of Public and Occupational Health, EMGO+ Institute for Health and Care ResearchVU University Medical CentreAmsterdamThe Netherlands

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