Evaluation of the Quality of Life in Adult Cancer Survivors (QLACS) scale for early post-treatment breast cancer survivors
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The end of primary treatment for cancer patients is increasingly recognized as an important time of adjustment that may impact quality of life (QoL). A psychometrically sound QoL instrument that assesses the mix of acute and longer-term concerns present during this unique time has not yet been identified. This article evaluates the Quality of Life in Adult Cancer Survivors (QLACS) scale, originally developed for long-term (>5 years) cancer survivors, as an appropriate QoL measure for this transition period.
Psychometric properties of the QLACS were evaluated in a sample of post-treatment breast cancer survivors 18–24 months post-diagnosis. This observational study consisted of women (n = 552) aged 25 years and older (mean = 55.4 years) who were diagnosed with stage I, II, or III breast cancer. The 47 items of the QLACS comprise 12 domains: seven domains are generic, and five are cancer specific.
The QLACS demonstrated adequate internal consistency (Cronbach’s alpha for the 12 domains ranged from 0.79 to 0.91) and good convergent and divergent validity (assessed by comparison with the Functional Assessment of Cancer Therapy and other measures).
The QLACS appears to be consistent with other widely accepted measures in capturing QoL, while also allowing for more inclusive measurement of specific issues relevant to post-treatment cancer survivors. These data, in addition to previous data supporting use of the QLACS across different cancer sites, suggest that the QLACS is a promising comprehensive QoL measure appropriate for breast cancer survivors transitioning off active treatment.
KeywordsCancer Oncology Quality of life Survivorship Measurement
- 3.Howlader N., Noone A. M., Krapcho M., Garshell J., Miller D., Altekruse S.F., et al. (2014). SEER Cancer Statistics Review, 1975–2011. Bethesda, MD: National Cancer Institute. Retrieved April 21, 2014 from : http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission.
- 8.Sprangers, M. A., Groenvold, M., Arraras, J. I., Franklin, J., te Velde, A., Muller, M., et al. (1996). The European Organization for Research and Treatment of Cancer breast cancer-specific quality-of-life questionnaire module: first results from a three-country field study. Journal of Clinical Oncology, 14(10), 2756–2768.PubMedGoogle Scholar
- 9.Kroenke, C.H., Kwan, M.L., Neugut, A.,I., Ergas, I. J., Wright, J.D., Caan, B.J. et al. (2013) Social networks, social support mechanisms after breast cancer diagnosis. Breast Cancer Research and Treatment, 139, 515–527.Google Scholar
- 10.Kwan, M. L., Ergas, I. J., Somkin, C. P., Quesenberry, C. P., Jr, Neugut, A. I., Hershman, D., et al. (2010). Quality of life among women recently diagnosed with invasive breast cancer: The pathways study. Breast Cancer Research and Treatment, 123(2), 507–524.PubMedCentralPubMedCrossRefGoogle Scholar
- 14.Avis, N.E., Smith, K.W., McGraw, S., Smith, R.G., Petronis, V.M., & Carver, C.S. (2005). Assessing quality of life in adult cancer survivors (QLACS). Quality of Life Research, 14(4), 1007–1023.Google Scholar
- 18.Lee, E. S., Lee, M. K., Kim, S. H., Ro, J. S., Kang, H. S., Kim, S. W., et al. (2011). Health-related quality of life in survivors with breast cancer 1 year after diagnosis compared with the general population: A prospective cohort study. Annals of Surgery, 253(1), 101–108.PubMedCrossRefGoogle Scholar
- 19.Taira, N., Shimozuma, K., Shiroiwa, T., Ohsumi, S., Kuroi, K., Saji, S., et al. (2011). Associations among baseline variables, treatment-related factors and health-related quality of life 2 years after breast cancer surgery. Breast Cancer Research and Treatment, 128(3), 735–747.PubMedCrossRefGoogle Scholar
- 20.National Research Council. (2005). From cancer patient to cancer survivor: Lost in transition. Washington, D.C.: The National Academies Press.Google Scholar
- 26.Danhauer, S. C., Case, L. D., Tedeschi, R., Russell, G., Vishnevsky, T., Triplett, K., et al. (2013). Predictors of posttraumatic growth in women with breast cancer. Psycho-Oncology, 22(12), 2676–83.Google Scholar
- 27.Sohl, S.J., Levine, B., Case, L.D., Danhauer, S.C., & Avis, N.E. (2014). Trajectories of illness intrusiveness domains following a diagnosis of breast cancer. Health Psychology, 33(3), 232–41.Google Scholar
- 32.De Boer, A. G. E. M., van Lanschot, J. J. B., Stalmeier, P. F. M., van Sandick, J. W., Hulscher, J. B. F., de Haes, J. C. J. M., et al. (2004). Is a single-item visual analogue scale as valid, reliable and responsive as multi-item scales in measuring quality of life? Quality of Life Research, 13(2), 311–320.PubMedCrossRefGoogle Scholar
- 33.Barnabei, V. M., Cochrane, B. B., Aragaki, A. K., Nygaard, I., Williams, R. S., McGovern, P. G., et al. (2005). Menopausal symptoms and treatment-related effects of estrogen and progestin in the Women’s Health Initiative. Obstetrics and Gynecology, 105(5 Pt 1), 1063–1073.PubMedCrossRefGoogle Scholar
- 36.Devins, G. M., Binik, Y. M., Hutchinson, T. A., Hollomby, D. J., Barré, P. E., & Guttmann, R. D. (1983). The emotional impact of end-stage renal disease: Importance of patients’ perception of intrusiveness and control. International Journal of Psychiatry in Medicine, 13(4), 327–343.PubMedCrossRefGoogle Scholar