Quality of Life Research

, Volume 23, Issue 10, pp 2735–2741 | Cite as

Factors associated with quality of life measured by EQ-5D in patients with nontuberculous mycobacterial pulmonary disease

  • Ji Young Hong
  • Sang A. Lee
  • Song Yee Kim
  • Kyung Soo Chung
  • Sung Woo Moon
  • Eun Young Kim
  • Ji Ye Jung
  • Moo Suk Park
  • Young Sam Kim
  • Se Kyu Kim
  • Joon Chang
  • Young Ae KangEmail author



The impact of pulmonary nontuberculous mycobacterial (pNTM) disease on health-related quality of life (HRQoL) has not received significant attention in the literature. In this study, we compared the HRQoL in patients with pNTM disease and healthy subjects and identified influencing factors using EuroQol 5D (EQ-5D) data.


The present study used an age- and sex-matched case–control analysis from a cohort of 85 pNTM patients and 340 participants from a national survey. Baseline EQ-5D utility scores and EQ-5D visual analog scale (VAS) scores were measured in both groups. In patients with pNTM disease, the factors affecting EQ-5D were identified using multiple linear regression analysis.


While the median EQ-5D VAS scores were lower in pNTM patients than in the control subjects (pNTM, 70; control, 80; P < 0.001), the median EQ-5D utility scores were similar in two groups (both, 1.000, P = 0.878). Interestingly, the percentage of subjects reporting problems on the anxiety/depression dimension was higher for patients with pNTM disease (18.8 %) compared with the control subjects (11.5 %, P = 0.07). In multivariate analysis, increasing severity of forced expired volume in one second (FEV1) decline was associated with a significant decrease in EQ-5D scores of pNTM patients.


This study suggested the EQ-5D may not be useful instrument in pNTM patients due to ceiling effect of EQ-5D and mild disease activity. Patients with pNTM disease tended to report more reduced health status and more problems with anxiety/depression than the healthy controls. Lung function, measured by FEV1, was independently associated with EQ-5D scores in patients with pNTM disease.


Nontuberculous mycobacterium Quality of life EQ-5D 



This work was supported by a National Research Foundation of Korea Grant funded by the Korean Government (2011-0013018).

Conflict of interest

Authors have no conflict of interest including financial, personal, academic and intellectual.


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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • Ji Young Hong
    • 1
  • Sang A. Lee
    • 2
  • Song Yee Kim
    • 1
  • Kyung Soo Chung
    • 1
  • Sung Woo Moon
    • 1
  • Eun Young Kim
    • 1
  • Ji Ye Jung
    • 1
  • Moo Suk Park
    • 1
  • Young Sam Kim
    • 1
  • Se Kyu Kim
    • 1
  • Joon Chang
    • 1
  • Young Ae Kang
    • 1
    Email author
  1. 1.Division of Pulmonology, Department of Internal MedicineYonsei University College of MedicineSeoulRepublic of Korea
  2. 2.Graduate SchoolYonsei University College of NursingSeoulRepublic of Korea

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