Quality of Life Research

, Volume 22, Issue 10, pp 2631–2637 | Cite as

Using patient-reported measurement to pave the path towards personalized medicine

  • Mirjam A. G. Sprangers
  • Per Hall
  • Donald E. Morisky
  • William E. Narrow
  • Juan Dapueto
Review

Abstract

Objective

Given the potential and importance of personalized or individualized medicine for health care delivery and its effects on patients’ quality of life, a plenary session was devoted to personalized medicine during the 19th Annual Conference of the International Society for Quality of Life Research held in October 2012 in Budapest, Hungary. This paper summarizes the three presentations and discusses their implications for quality-of-life research.

Methods

Reviews of the literature and presentation of empirical studies.

Results

Personalized screening for breast cancer. To individualize screening and only target those women with an increased risk for breast cancer, researchers at the Karolinska Institutet in Stockholm perform a large population-based study to identify high-risk women based on lifestyle, genetics, mammographic morphology, and other markers as well as quality of life. Personalized support for treatment adherence. Inclusion of a simple, brief adherence measure into the clinical visit has demonstrated significant improvement in medication-taking behaviour and resultant improvement in health status. Personalized diagnosis of mental disorders. The DSM-5, the current manual for mental disorders, contains patient-based symptom and diagnosis severity measures that allow more individualized diagnosis than was hitherto possible.

Conclusions

Personalized medicine will continue to be increasingly applied and holds the potential to improve health outcomes including quality of life. At the same time, it will invite a host of new ethical, practical, and psychosocial questions. Further reflection and discussion of how our field can embrace and address these emerging challenges is needed.

Keywords

Personalized medicine Screening Breast cancer Lifestyle change Adherence Psychiatric diagnosis DSM-5 

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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Mirjam A. G. Sprangers
    • 1
  • Per Hall
    • 2
  • Donald E. Morisky
    • 3
  • William E. Narrow
    • 4
  • Juan Dapueto
    • 5
  1. 1.Department of Medical Psychology, Academic Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands
  2. 2.Department of Medical Epidemiology and BiostatisticsKarolinska InstitutetStockholmSweden
  3. 3.Department of Community Health SciencesUCLA Fielding School of Public HealthLos AngelesUSA
  4. 4.Division of Research American Psychiatric AssociationArlingonUSA
  5. 5.Department of Medical Psychology, Faculty of MedicineUniversidad de la RepúblicaMontevideoUruguay

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