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Quality of Life Research

, Volume 22, Issue 10, pp 2865–2876 | Cite as

An examination of the PROMIS® pediatric instruments to assess mobility in children with cerebral palsy

  • Anna L. KratzEmail author
  • Mary D. Slavin
  • M. J. Mulcahey
  • Alan M. Jette
  • David S. Tulsky
  • Stephen M. Haley
Article

Abstract

Purpose

The Patient-Reported Outcomes Measurement Information System (PROMIS®) provides adult and pediatric self-report measures of health-related quality of life designed for use across medical conditions and the general population. The purpose of this study was to examine the feasibility and validity of the PROMIS® Pediatric Short Form and computer-adaptive test (CAT) mobility measures in children with cerebral palsy (CP).

Methods

Eighty-two children with CP completed self-report (PROMIS® Mobility Short Form, PROMIS® Mobility CAT, Pediatric Quality of Life Inventory™) and performance-based assessments of mobility (Timed Up and Go, Gross Motor Function Measure). Parents provided three proxy reports of child mobility (Pediatric Outcomes Data Collection Instrument, Functional Assessment Questionnaire, Shriners Hospitals for Children CP-CAT). Validity of PROMIS® instruments was examined through correlations with other measures and “known groups” analyses determined by Gross Motor Function Classification System (GMFCS).

Results

On average, the PROMIS® CAT required less than seven items and 2 minutes to administer. Both PROMIS® measures showed moderate to high correlations with child- and parent-proxy report of child mobility; correlations with performance-based measure were small for the PROMIS® Short Form and non-significant for the PROMIS® CAT. All measures except for the PROMIS® CAT were able to distinguish between GMFCS categories.

Conclusions

Results support the convergent and discriminant validity of the pediatric PROMIS® Mobility Short Form in children with CP. The PROMIS® Mobility CAT correlates well with child report and parent report of mobility but not with performance-based measures and does not differentiate between known mobility groups.

Keywords

Cerebral palsy PROMIS® Mobility Computer-adaptive test Validity 

Notes

Acknowledgments

The Patient-Reported Outcomes Measurement Information System (PROMIS®) is an NIH Roadmap initiative to develop a computerized system measuring PROs in respondents with a wide range of chronic diseases and demographic characteristics. PROMIS® II was funded by cooperative agreements with a Statistical Center (Northwestern University, PI: David Cella, PhD, 1U54AR057951), a Technology Center (Northwestern University, PI: Richard C. Gershon, PhD, 1U54AR057943), a Network Center (American Institutes for Research, PI: Susan (San) D. Keller, PhD, 1U54AR057926) and thirteen Primary Research Sites which may include more than one institution (State University of New York, Stony Brook, PIs: Joan E. Broderick, PhD and Arthur A. Stone, PhD, 1U01AR057948; University of Washington, Seattle, PIs: Heidi M. Crane, MD, MPH, Paul K. Crane, MD, MPH, and Donald L. Patrick, PhD, 1U01AR057954; University of Washington, Seattle, PIs: Dagmar Amtmann, PhD and Karon Cook, PhD, 1U01AR052171; University of North Carolina, Chapel Hill, PI: Darren A. DeWalt, MD, MPH, 2U01AR052181; Children’s Hospital of Philadelphia, PI: Christopher B. Forrest, MD, PhD, 1U01AR057956; Stanford University, PI: James F. Fries, MD, 2U01AR052158; Boston University, PIs: Alan Jette, PhD and David Scott Tulsky, PhD (University of Michigan, Ann Arbor), 1U01AR057929; University of California, Los Angeles, PIs: Dinesh Khanna, MD and Brennan Spiegel, MD, MSHS, 1U01AR057936; University of Pittsburgh, PI: Paul A. Pilkonis, PhD, 2U01AR052155; Georgetown University, PIs: Carol. M. Moinpour, PhD (Fred Hutchinson Cancer Research Center, Seattle) and Arnold L. Potosky, PhD, U01AR057971; Children’s Hospital Medical Center, Cincinnati, PI: Esi M. Morgan DeWitt, MD, MSCE, 1U01AR057940; University of Maryland, Baltimore, PI: Lisa M. Shulman, MD, 1U01AR057967; and Duke University, PI: Kevin P. Weinfurt, PhD, 2U01AR052186). NIH Science Officers on this project have included Deborah Ader, PhD, Vanessa Ameen, MD, Susan Czajkowski, PhD, Basil Eldadah, MD, PhD, Lawrence Fine, MD, DrPH, Lawrence Fox, MD, PhD, Lynne Haverkos, MD, MPH, Thomas Hilton, PhD, Laura Lee Johnson, PhD, Michael Kozak, PhD, Peter Lyster, PhD, Donald Mattison, MD, Claudia Moy, PhD, Louis Quatrano, PhD, Bryce Reeve, PhD, William Riley, PhD, Ashley Wilder Smith, PhD, MPH, Susana Serrate-Sztein,MD, Ellen Werner, PhD and James Witter, MD, PhD. This manuscript was reviewed by PROMIS® reviewers before submission for external peer review. See the Web site at www.nihpromis.org for additional information on the PROMIS initiative. The content of this manuscript is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Partial funding for this study was also provided by the Shriners Hospitals for Children Grant# 79120 (Mulcahey, PI). The Shriners Hospital for Children Philadelphia, Chicago, Montreal, Houston, Greenville and Portland Hospitals are acknowledged for their support in data collection.

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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Anna L. Kratz
    • 1
    Email author
  • Mary D. Slavin
    • 2
  • M. J. Mulcahey
    • 3
  • Alan M. Jette
    • 2
  • David S. Tulsky
    • 4
  • Stephen M. Haley
    • 2
  1. 1.Department of Physical Medicine and RehabilitationUniversity of MichiganAnn ArborUSA
  2. 2.Health and Disability Research InstituteBoston University School of Public HealthBostonUSA
  3. 3.Jefferson School of Health ProfessionsThomas Jefferson UniversityPhiladelphiaUSA
  4. 4.Department of Physical Medicine and Rehabilitation, The Center for Rehabilitation Outcomes and Assessment ResearchUniversity of MichiganAnn ArborUSA

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