Quality of Life Research

, Volume 22, Issue 7, pp 1537–1541 | Cite as

Health-related quality of life in patients with interstitial cystitis/bladder pain syndrome and frequently associated comorbidities

  • Anne M. Suskind
  • Sandra H. Berry
  • Marika J. Suttorp
  • Marc N. Elliott
  • Ron D. Hays
  • Brett A. Ewing
  • J. Quentin Clemens



To estimate the association of chronic non-urologic conditions [i.e., fibromyalgia (FM), chronic fatigue syndrome (CFS), and irritable bowel syndrome (IBS)] with health-related quality of life (HRQOL) in patients with interstitial cystitis/bladder pain syndrome (IC/BPS).


A total of 276 women with established diagnoses of IC/BPS completed a telephone interview which included demographics, self-reported medical conditions, the SF-36 health survey, and the interstitial cystitis symptom index (ICSI). Multivariate linear regression analysis was used to identify correlates of SF-36 physical and mental component summary scores.


Mean patient age was 45.1 (SD 15.9) years, and 83 % of the subjects were white. Mean values for the SF-36 Physical Component Score (PCS) and Mental Component Score (MCS) means were 39 (SD 14) and 45 (SD 12), respectively, indicating significant HRQOL reductions. Mean ICSI score was 11.27 (SD = 4.86). FM and IBS were significantly associated with worse SF-36 scores: −8 points on the PCS (p < 0.001) and −6 points on the MCS (p < 0.001). CFS and the presence of other pelvic conditions (overactive bladder, vulvodynia, endometriosis) were not significantly associated with SF-36 PCS and MCS scores.


In patients with IC/BPS, the presence of FM, CFS, and IBS has a significant association with HRQOL, equivalent in impact to the bladder symptoms themselves. These results emphasize the importance of a multidisciplinary approach to treating patients with IC/BPS and other conditions.


Fibromyalgia Chronic fatigue syndrome Irritable bowel syndrome Quality of life 



Ron D. Hays was supported in part by grants from the NIA (P30AG021684) and the NIMHD (2P20MD000182). This study was supported by National Institute of Diabetes and Digestive Kidney Diseases Grant (U10DK070234-01).


  1. 1.
    Berry, S. H., Elliott, M. N., Suttorp, M., Bogart, L. M., Stoto, M. A., Eggers, P., et al. (2011). Prevalence of symptoms of bladder pain syndrome/interstitial cystitis among adult females in the United States. Journal of Urology, 186(2), 540–544. doi: 10.1016/j.juro.2011.03.132. (Research Support, N.I.H., Extramural).PubMedCrossRefGoogle Scholar
  2. 2.
    Nickel, J. C., Tripp, D. A., Pontari, M., Moldwin, R., Mayer, R., Carr, L. K., et al. (2010). Psychosocial phenotyping in women with interstitial cystitis/painful bladder syndrome: a case control study. Journal of Urology, 183(1), 167–172. doi: 10.1016/j.juro.2009.08.133.PubMedCrossRefGoogle Scholar
  3. 3.
    El Khoudary, S. R., Talbott, E. O., Bromberger, J. T., Chang, C. C., Songer, T. J., & Davis, E. L. (2009). Severity of interstitial cystitis symptoms and quality of life in female patients. Journal of Women’s Health, 18(9), 1361–1368. doi: 10.1089/jwh.2008.1270. [Clinical TrialResearch Support, Non-U.S. Gov’t].PubMedCrossRefGoogle Scholar
  4. 4.
    Clemens, J. Q., Meenan, R. T., O’Keeffe Rosetti, M. C., Kimes, T. A., & Calhoun, E. A. (2008). Case-control study of medical comorbidities in women with interstitial cystitis. Journal of Urology, 179(6), 2222–2225. doi: 10.1016/j.juro.2008.01.172.PubMedCrossRefGoogle Scholar
  5. 5.
    Alagiri, M., Chottiner, S., Ratner, V., Slade, D., & Hanno, P. M. (1997). Interstitial cystitis: unexplained associations with other chronic disease and pain syndromes. Urology, 49(5A Suppl), 52–57. [Comparative Study].PubMedCrossRefGoogle Scholar
  6. 6.
    Nickel, J. C., Tripp, D. A., Pontari, M., Moldwin, R., Mayer, R., Carr, L. K., et al. (2010). Interstitial cystitis/painful bladder syndrome and associated medical conditions with an emphasis on irritable bowel syndrome, fibromyalgia and chronic fatigue syndrome. Journal of Urology, 184(4), 1358–1363. doi: 10.1016/j.juro.2010.06.005.PubMedCrossRefGoogle Scholar
  7. 7.
    Berry, S. H., Bogart, L. M., Pham, C., Liu, K., Nyberg, L., Stoto, M., et al. (2010). Development, validation and testing of an epidemiological case definition of interstitial cystitis/painful bladder syndrome. Journal of Urology, 183(5), 1848–1852. doi: 10.1016/j.juro.2009.12.103. (Research Support, N.I.H., Extramural Validation Studies).PubMedCrossRefGoogle Scholar
  8. 8.
    Ware, J. E., Kosinski, M., & Gandek, B. (2005). SF-36 health survey: Manual and interpretation guide. Lincoln: Quality Metric, Inc.Google Scholar
  9. 9.
    Fenton, B. W. (2010). Measuring quality of life in chronic pelvic pain syndrome. Expert Review of Obstetrics & Gynecology, 5(1), 115–124.CrossRefGoogle Scholar
  10. 10.
    Michael, Y. L., Kawachi, I., Stampfer, M. J., Colditz, G. A., & Curhan, G. C. (2000). Quality of life among women with interstitial cystitis. Journal of Urology, 164(2), 423–427. [Comparative Study Research Support, U.S. Gov’t, P.H.S.].PubMedCrossRefGoogle Scholar
  11. 11.
    Tripp, D. A., Nickel, J. C., Fitzgerald, M. P., Mayer, R., Stechyson, N., & Hsieh, A. (2009). Sexual functioning, catastrophizing, depression, and pain, as predictors of quality of life in women with interstitial cystitis/painful bladder syndrome. Urology, 73(5), 987–992. doi: 10.1016/j.urology.2008.11.049. (Research Support, N.I.H., Extramural).PubMedCrossRefGoogle Scholar
  12. 12.
    Propert, K. J., Mayer, R. D., Wang, Y., Sant, G. R., Hanno, P. M., Peters, K. M., et al. (2006). Responsiveness of symptom scales for interstitial cystitis. Urology, 67(1), 55–59. doi: 10.1016/j.urology.2005.07.014. (Research Support, N.I.H., Extramural).PubMedCrossRefGoogle Scholar
  13. 13.
    Novi, J. M., Jeronis, S., Srinivas, S., Srinivasan, R., Morgan, M. A., & Arya, L. A. (2005). Risk of irritable bowel syndrome and depression in women with interstitial cystitis: A case-control study. Journal of Urology, 174(3), 937–940. doi: 10.1097/01.ju.0000169258.31345.5d.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Anne M. Suskind
    • 1
  • Sandra H. Berry
    • 2
  • Marika J. Suttorp
    • 2
  • Marc N. Elliott
    • 2
  • Ron D. Hays
    • 2
  • Brett A. Ewing
    • 2
  • J. Quentin Clemens
    • 1
  1. 1.Department of Urology, University of Michigan Health SystemUniversity of MichiganAnn ArborUSA
  2. 2.RAND CorporationSanta MonicaUSA

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