Quality of Life Research

, Volume 22, Issue 6, pp 1281–1286 | Cite as

Impact of nocturnal calf cramping on quality of sleep and health-related quality of life

  • Fiona HawkeEmail author
  • Vivienne Chuter
  • Joshua Burns



To evaluate the impact of nocturnal calf cramping (a condition that affects one in two people over 60 years of age) on quality of sleep and health-related quality of life.


Eighty adults who experienced nocturnal calf cramp at least once per week and eighty age- and sex-matched controls who never experienced nocturnal cramp were recruited from the Greater Newcastle and Central Coast regions of New South Wales, Australia. All participants completed the SF-36v2 and the Medical Outcomes Study Sleep Survey (MOS-SS).


People who experienced nocturnal muscle cramps reported more sleep disturbance (p < 0.001), less adequate sleep (p = 0.001), less quantity of sleep (p = 0.02) and more snoring (p = 0.03). Both sleep problem summary indices for the MOS-SS identified people who experienced nocturnal muscle cramp as having more sleep problems than the controls. People who experienced nocturnal muscle cramps had lower health-related quality of life for the SF-36 domains role physical (p = 0.007), bodily pain (p = 0.003) and general health (p = 0.02). SF-36 domains that primarily relate to mental health were not significantly different between groups. The impact of nocturnal calf cramps on health-related quality of life was largely explained by their negative impact on quality of sleep.


Nocturnal calf muscle cramps are associated with substantially reduced quality of sleep and reduced physical aspects of health-related quality of life.


Cramp Sleep quality Quality of life Sleep disturbance Gastrocnemius Ageing 



Fiona Hawke received funding for this research from a University of Sydney Postgraduate Award and internal staff grants from the University of Newcastle. The authors acknowledge the assistance of Sean Sadler with data entry.

Conflict of interest

Fiona Hawke receives financial support from the University of Sydney and the University of Newcastle. Vivienne Chuter reports no conflicts of interest. Joshua Burns has received research support from the NHMRC (National Health and Medical Research Council of Australia, Fellowship #1007569 and Centre of Research Excellence #1031893), NIH (National Institutes of Neurological Disorders and Stroke and Office of Rare Diseases, #U54NS065712), Australian Podiatry Education and Research Foundation, Podiatry Council of New South Wales, Charcot Marie Tooth Association, Muscular Dystrophy Association, CMT Association of Australia.


  1. 1.
    Abdulla, A., Jones, P., & Pearce, V. (1999). Leg cramps in the elderly: Prevalence, drug and disease associations. International Journal of Clinical Practice, 53(7), 494–496.PubMedGoogle Scholar
  2. 2.
    Blyton, F., Chuter, V., & Burns, J. (2012). Unknotting night-time muscle cramp: A survey of patient experience, help-seeking behaviour and perceived treatment effectiveness. Journal of Foot and Ankle Research, 5(7), 1–8.Google Scholar
  3. 3.
    Gootnick, A. (1943). Night cramps and quinine. Archives of Internal Medicine, 106(1), 555–562.CrossRefGoogle Scholar
  4. 4.
    Redmond, A., Burns, J., & Ouvrier, R. (2008). Factors that influence health-related quality of life in Australian adults with Charcot-Marie-Tooth disease. Neuromuscular Disorders, 18, 619–625.PubMedCrossRefGoogle Scholar
  5. 5.
    Burns, J., Ramchandren, S., Ryan, M., Shy, M., & Ouvrier, R. (2010). Determinants of reduced health related quality of life in pediatric inherited neuropathies. Neurology, 75(8), 726–731.PubMedCrossRefGoogle Scholar
  6. 6.
    Jansen, P., Joosten, E., Van Dijck, J., Verbeek, A., & Durian, F. (1991). The incidence of muscle cramp. Journal of Neurology, Neurosurgery and Psychiatry, 54(12), 1124–1125.PubMedCrossRefGoogle Scholar
  7. 7.
    Gulich, M., Heil, P., & Zeitler, H. (1998). Epidemiology and determinants of cramps. European Journal of General Practice, 4, 109–113.CrossRefGoogle Scholar
  8. 8.
    Ferreira, J., Desboeuf, K., Galitzky, M., Thalamas, C., Brefel-Courbon, C., Fabre, N., et al. (2006). Sleep disruption, daytime somnolence and ‘sleep attacks’ in Parkinson’s disease: A clinical survey in PD patients and age-matched healthy volunteers. European Journal of Neurology, 13, 209–214.PubMedCrossRefGoogle Scholar
  9. 9.
    Van den Bergh, P., Bulcke, J. A., & Dom, R. (1980). Familial muscle cramps with autosomal dominant transmission. European Neurology, 19(3), 207–212.PubMedCrossRefGoogle Scholar
  10. 10.
    Bagai, K., Song, Y., Ling, J. F., Malow, B., Black, B. K., Biaggioni, I., et al. (2011). Sleep disturbances and diminished quality of life in postural tachycardia syndrome. Journal of Clinical Sleep Medicine, 7(2), 204–210.PubMedGoogle Scholar
  11. 11.
    Mendozzi, L., Tronci, F., Garegnani, M., & Pugnetti, L. (2010). Sleep disturbance and fatigue in mild relapsing remitting multiple sclerosis patients on chronic immunomodulant therapy: An actigraphic study. Multiple Sclerosis, 16(2), 238–247.PubMedCrossRefGoogle Scholar
  12. 12.
    Cappelleri, J. C., Bushmakin, A. G., McDermott, A. M., Dukes, E., Sadosky, A., Petrie, C. D., et al. (2009). Measurement properties of the medical outcomes study sleep scale in patients with fibromyalgia. Sleep Medicine, 10(7), 766–770.PubMedCrossRefGoogle Scholar
  13. 13.
    Hays, R. D., Martin, S. A., Sesti, A. M., & Spritzer, K. L. (2005). Psychometric properties of the medical outcomes study sleep measure. Sleep Medicine, 6(1), 41–44.PubMedCrossRefGoogle Scholar
  14. 14.
    Allen, R. P., Kosinski, M., Hill-Zabala, C. E., & Calloway, M. O. (2009). Psychometric evaluation and tests of validity of the medical outcomes study 12-item sleep scale (MOS sleep). Sleep Medicine, 10(5), 531–539.PubMedCrossRefGoogle Scholar
  15. 15.
    Wells, G. A., Li, T., Kirwan, J. R., Peterson, J., Aletaha, D., Boers, M., et al. (2009). Assessing quality of sleep in patients with rheumatoid arthritis. Journal of Rheumatology, 36(9), 2077–2086.PubMedCrossRefGoogle Scholar
  16. 16.
    Hawthorne, G., Osborne, R. H., Taylor, A., & Sansoni, J. (2007). The SF36 version 2: Critical analyses of population weights, scoring algorithms and population norms. Quality of Life Research, 16(4), 661–673.PubMedCrossRefGoogle Scholar
  17. 17.
    Spritzer, K. L., & Hays, R. D. (2003). MOS sleep scale: A manual for use and scoring, version 1.0. Los Angeles, CA.Google Scholar
  18. 18.
    Hawke, F., Chuter, V., & Burns, J. (2012). Factors associated with night-time calf cramp: A case control study. Muscle and Nerve. (Accepted for publication 17 July).Google Scholar
  19. 19.
    Pallant, J. (2007). SPSS survival manual: A step by step guide to data analysis using SPSS (3rd ed.). Sydney: Allen & Unwin.Google Scholar
  20. 20.
    Livingston, G., Blizard, B., & Mann, A. (1993). Does sleep disturbance predict depression in elderly people? A study in inner London. British Journal of General Practice, 43(376), 445–448.PubMedGoogle Scholar
  21. 21.
    Cho, H. J., Lavretsky, H., Olmstead, R., Levin, M. J., Oxman, M. N., Irwin, M. R., et al. (2008). Sleep disturbance and depression recurrence in community-dwelling older adults: A prospective study. American Journal of Psychiatry, 165(12), 1543–1550.PubMedCrossRefGoogle Scholar
  22. 22.
    Dew, M. A., Hoch, C. C., Buysse, D. J., Monk, T. H., Begley, A. E., & Houck, P. R., et al. (2003). Healthy older adults’ sleep predicts all-cause mortality at 4 to 19 years of follow-up. (Erratum appears in Psychosom Med. 2003 Mar-Apr; 65(2):210). Psychosomatic Medicine, 65(1), 63–73.Google Scholar
  23. 23.
    Gentili, A., Weiner, D., Kuchibhatla, M., & Edinger, J. (1997). Factors that disturb sleep in nursing home residents. Aging, 9(3), 207–213.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Fiona Hawke
    • 1
    • 2
    • 5
    Email author
  • Vivienne Chuter
    • 2
  • Joshua Burns
    • 1
    • 3
    • 4
  1. 1.Discipline of Paediatrics and Child Health, Sydney Medical SchoolThe University of SydneyWestmeadAustralia
  2. 2.Podiatry ProgramThe University of NewcastleOurimbahAustralia
  3. 3.Arthritis and Musculoskeletal Research Group, Faculty of Health SciencesThe University of SydneySydneyAustralia
  4. 4.Institute for Neuroscience and Muscle ResearchThe Children’s Hospital at WestmeadWestmeadAustralia
  5. 5.Health PrecinctThe University of NewcastleOurimbahAustralia

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