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Quality of Life Research

, Volume 22, Issue 4, pp 715–723 | Cite as

Prognostic value of quality of life measured after treatment on subsequent survival in patients with nasopharyngeal carcinoma

  • Wen-Ling Tsai
  • Chih-Yen Chien
  • Hsuan-Ying Huang
  • Kuan-Cho Liao
  • Fu-Min FangEmail author
Article

Abstract

Purpose

Pretreatment quality of life (QoL) has been used to predict survival in cancer patients. In this study, we examined the prognostic value of QoL measured after treatment on subsequent survival in patients with nasopharyngeal carcinoma (NPC).

Methods

We enrolled 273 patients with NPC who had been curatively treated for more than 1 year. The EORTC QLQ-C30 and H&N35 questionnaires were completed 1 year after radiotherapy. The predictability of QoL variables on disease-specific survival (DSS) and overall survival (OS) was analyzed using Cox’s proportional hazards models.

Results

Twenty-nine (10.6 %) patients developed locoregional relapse and 27 (9.9 %) had distant metastasis after the QoL survey with subsequent 5-year DSS and OS rates of 87.9 % and 84.0 %, respectively. Based on the QLQ-C30, scales of physical functioning, fatigue, and appetite loss significantly predicted DSS and OS (p < 0.05). In the H&N35, only sexuality was significantly correlated with DSS and OS (p < 0.05). An increment of 10 points in physical functioning (HR: 0.69; 95 % CI: 0.48–0.90; p = 0.004) or a decline of 10 points in fatigue problems (HR: 1.40; 95 % CI: 1.19–1.61; p = 0.0002), appetite loss (HR: 1.21; 95 % CI: 1.03–1.40; p = 0.02), and sexuality (HR: 1.14; 95 % CI: 1.02–1.25; p = 0.019) was associated with better OS.

Conclusion

Some QoL variables measured after the treatment provide prognostic value on subsequent survival in patients with NPC.

Keywords

Quality of life Nasopharyngeal carcinoma EORTC QLQ-C30 H&N35 Subsequent survival 

Abbreviations

EORTC

European organization of research and treatment of cancer

HR

Hazard ratio

CI

Confidence interval

Notes

Acknowledgments

Supported by Grant “NSC 90-2320-B-182A-006-” from the National Science Council, Taiwan; “CMRPG860502” and “CMRPG860503” from the Chang Gung Memorial Hospital, Taiwan.

Conflict of interest

No financial disclosure from any author.

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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Wen-Ling Tsai
    • 1
  • Chih-Yen Chien
    • 2
  • Hsuan-Ying Huang
    • 3
  • Kuan-Cho Liao
    • 4
  • Fu-Min Fang
    • 4
    Email author
  1. 1.Department of Biotechnical CosmetologyCheng Shiu UniversityKaohsiungTaiwan
  2. 2.Department of OtolaryngologyKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiungTaiwan
  3. 3.Department of PathologyKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiungTaiwan
  4. 4.Department of Radiation OncologyKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineNiao Sung District, Kaohsiung CityTaiwan

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