Quality of Life Research

, Volume 22, Issue 2, pp 253–261 | Cite as

Physical activity, self-efficacy, and health-related quality of life in persons with multiple sclerosis: analysis of associations between individual-level changes over one year

  • Robert W. Motl
  • Edward McAuley
  • Daniel Wynn
  • Brian Sandroff
  • Yoojin Suh



Physical activity and self-efficacy represent behavioral and psychological factors, respectively, that are compromised in persons with multiple sclerosis (MS), but might be modifiable through intervention and result in better health-related quality of life (HRQOL).


The present study adopted a panel research design and examined the associations between individual-level changes in physical activity, self-efficacy, and HRQOL over a one-year period in persons with MS.


The sample consisted of 269 persons with relapsing–remitting MS who completed the Godin Leisure-Time Questionnaire (GLTEQ), Multiple Sclerosis Self-Efficacy (MSSE) Scale, and Multiple Sclerosis Quality of Life—29 (MSIS-29) Scale on two occasions that were separated by 1 year. The data were analyzed using panel analysis in Mplus 3.0.


The initial panel analysis indicated that individual-level change in physical activity was associated with individual-level change in both physical and psychological HRQOL. The subsequent panel analysis indicated that (a) individual-level change in self-efficacy for functioning with MS was associated with individual-level change in physical HRQOL, whereas individual-level change in self-efficacy for control was associated with individual-level change in psychological HRQOL; (b) individual-level change in self-efficacy for functioning with MS, but not self-efficacy for control, mediated the association between individual-level change in physical activity and physical HRQOL; and (c) individual-level change in self-efficacy for controlling MS was the strongest predictor of individual-level change in HRQOL.


Physical activity and self-efficacy both might be important targets of subsequent behavioral and self-management interventions for improving the HRQOL of persons with MS, although self-efficacy is seemingly more important than physical activity.


Multiple sclerosis Self-efficacy Physical activity 



This investigation was supported by a grant from the National Multiple Sclerosis Society (RG 3926A2/1).


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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Robert W. Motl
    • 1
  • Edward McAuley
    • 1
  • Daniel Wynn
    • 2
  • Brian Sandroff
    • 1
  • Yoojin Suh
    • 1
  1. 1.Department of Kinesiology and Community HealthUniversity of IllinoisUrbanaUSA
  2. 2.Consultants in Neurology MS CenterNorthbrookUSA

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