Quality of Life Research

, Volume 21, Issue 1, pp 143–153

Circulating levels of a biomarker of collagen metabolism are associated with health-related quality of life in patients with chronic heart failure

  • Sofia V. Chatzikyriakou
  • Dimitrios N. Tziakas
  • Georgios K. Chalikias
  • Dimitrios Stakos
  • Dimitrios Papazoglou
  • Asimina Lantzouraki
  • Adina Thomaidi
  • Harisios Boudoulas
  • Stavros Konstantinides
Article

DOI: 10.1007/s11136-011-9932-5

Cite this article as:
Chatzikyriakou, S.V., Tziakas, D.N., Chalikias, G.K. et al. Qual Life Res (2012) 21: 143. doi:10.1007/s11136-011-9932-5

Abstract

Purpose

Assessment of circulating levels of collagen-derived peptides has been proposed as a useful tool to monitor indirectly myocardial collagen metabolism in chronic heart failure (CHF) patients. The potential link between circulating concentrations of collagen metabolism biomarkers and health-related quality of life (HRQOL) has not been adequately evaluated. With the present study, we investigated the association between serum levels of collagen-derived peptides and HRQOL.

Methods

We studied 280 consecutive outpatients (of mean age 67 ± 10 years, 180 men) with CHF. Serum concentrations of carboxy-terminal telopeptide of collagen type I (CITP)—a marker of collagen type I degradation—were measured in all patients both at baseline and during a period of 6 months follow-up. HRQOL was assessed by Minnesota living with heart failure questionnaire (MLHFQ).

Results

CITP levels were significantly associated with MLHFQ scores both at baseline (r = 0.231, P < 0.001) and at 6 months follow-up (r = 0.145, P = 0.044). CITP levels remained significantly associated with MLHFQ score in multivariable linear regression analysis. Higher CITP levels were observed with higher MLHFQ scores (poor HRQOL) both at baseline (P = 0.001) and at 6 months (P = 0.041). Unadjusted analysis demonstrated a significant relationship between increasing CITP levels during 6 months follow-up and worsening HRQOL (r = 0.204, P = 0.001). The aforementioned correlation remained significant in multivariable linear regression analysis.

Conclusion

Our findings show that increased CITP levels are associated with poorer HRQOL in patients with CHF. These findings are consistent with a link between a pathophysiologic mechanism, i.e., collagen metabolism and patient self-assessed health status in CHF.

Keywords

Health-related quality of life Collagen metabolism derived peptides Chronic heart failure 

Abbreviations

BMI

Body mass index

CHF

Chronic heart failure

CI

Confidence interval

CITP

Carboxy-terminal telopeptide of collagen type I

CRT

Cardiac resynchronization therapy

EF

Ejection fraction

HRQOL

Health-related quality of life

ICD

Implantable cardiac defribrillator

LV

Left ventricular

MLHFQ

Minnesota living with heart failure questionnaire

NYHA

New York Heart Association

SD

Standard deviation

SE

Standard error

Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Sofia V. Chatzikyriakou
    • 1
  • Dimitrios N. Tziakas
    • 1
  • Georgios K. Chalikias
    • 1
  • Dimitrios Stakos
    • 1
  • Dimitrios Papazoglou
    • 2
  • Asimina Lantzouraki
    • 1
  • Adina Thomaidi
    • 1
  • Harisios Boudoulas
    • 3
  • Stavros Konstantinides
    • 1
  1. 1.University Cardiology Department, Medical SchoolDemocritus University of ThraceAlexandroupolisGreece
  2. 2.University Internal Medicine Department, Medical SchoolDemocritus University of ThraceAlexandroupolisGreece
  3. 3.Center for Clinical Research, Foundation of Biomedical ResearchAcademy of AthensAthensGreece

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