Quality of Life Research

, Volume 21, Issue 6, pp 993–1003 | Cite as

The associations among coping, nadir CD4+ T-cell count, and non-HIV-related variables with health-related quality of life among an ambulatory HIV-positive patient population

Article

Abstract

Purpose

We investigated HRQoL among HIV-positive outpatients from October, 2006-December, 2007, incorporating medical chart review, and a survey of coping styles.

Methods

Consented HIV-positive patients receiving medical care at University of Colorado Denver, with HAART as first antiretroviral regimen, completed the MOS-HIV and Brief COPE survey instruments. Linear regression identified a priori factors hypothesized to be associated with the MOS-HIV composite mental and physical health scores (MHS, PHS). Brief COPE survey maladaptive and adaptive coping components were added to the models and retained if significant.

Results

Among the 157 patient cohort, parsimonious multivariable linear regression models (P < 0.05) indicated higher nadir CD4+ T-cell counts and adaptive coping were associated with a higher MHS; public/no insurance, mental illness, current number of non-HIV medications, and maladaptive coping were inversely associated with MHS. Nadir CD4+ T-cell count and efavirenz use were associated with a higher PHS; mental illness, current number of non-HIV mediations, and maladaptive coping were inversely associated with PHS.

Conclusions

Factors independently associated with lower MHS and lower PHS include lower nadir CD4+ T-cell counts, and use of maladaptive coping. Efforts to reduce use of maladaptive coping strategies and earlier identification and treatment of HIV may improve HRQoL in HIV-positive patients.

Keywords

HIV Nadir CD4+ T-cell count Coping Quality of life 

Abbreviations

AIDS

Acquired immunodeficiency syndrome

ART

Antiretroviral therapy

ARV

Antiretroviral

HAART

Highly active antiretroviral therapy

HIV

Human immunodeficiency virus

HRQoL

Health-related quality of life

IDGP

Infectious disease group practice

IDU

Intravenous drug user

IQR

Inter-quartile range

MHS

Mental health score

MOS

Medical outcomes study

MSM

Men who have sex with men

NRTI

Nucleoside analog reverse transcriptase inhibitor

NNRTI

Non-nucleoside analog reverse transcriptase inhibitor

PHS

Physical health score

PI

Protease inhibitor

SD

Standard deviation

UCHSC

University of Colorado Health Sciences Center

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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  1. 1.Children’s Hospital ColoradoAuroraUSA
  2. 2.National Jewish HealthDenverUSA

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